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Publikováno v:
Journal of Clinical Oncology. 41:1331-1338
PURPOSE Immunohistochemistry (IHC) is a newer technique for assessing the estrogen receptor (ER) status of breast cancers, with the potential to overcome many of the shortcomings associated with the traditional ligand-binding assay (LBA). The purpose
Autor:
Martin Bornhäuser, Michael Kramer, Jan-Niklas Eckardt, Christian Thiede, Johannes Schetelig, Karsten Wendt, Ulrich Schuler, Frank Kroschinsky, Jan Moritz Middeke, Katja Sockel, Christoph Röllig, Anas Shekh Sulaiman, Sebastian Riechert, Tim Schmittmann
Publikováno v:
Leukemia
The evaluation of bone marrow morphology by experienced hematopathologists is essential in the diagnosis of acute myeloid leukemia (AML); however, it suffers from a lack of standardization and inter-observer variability. Deep learning (DL) can proces
Publikováno v:
Modern Pathology. 34:1738-1749
Invasive stratified mucin-producing carcinoma (ISMC) is a recently described entity of human papillomavirus (HPV)-associated endocervical adenocarcinoma with phenotypic plasticity and aggressive clinical behavior. To identify the cell of origin of IS
Autor:
Yoshihiro Komohara, Toshiyuki Shima, Masayuki Shimoda, Remi Mito, Yusuke Shinchi, Koei Ikeda, Makoto Suzuki, Takuro Sakagami, Eri Matsubara, Yae Kanai, Yukio Fujiwara
Publikováno v:
Pathology International. 71:666-673
CD163 is one of the scavenger receptors expressed on macrophages. However, several immunohistochemical studies have demonstrated that CD163 is also detected on cancer cells, and is associated with a poor prognosis. In the present study, we detected C
Autor:
Martha A. Zeiger, Zhiyang Liu, Brittany A. McKelvey, Leslie Cope, Christopher B. Umbricht, Yongchun Wang, Lisa M. Rooper
Publikováno v:
J Cancer Res Clin Oncol
BACKGROUND: While molecular testing is a promising strategy for preoperative assessment of cytologically indeterminate thyroid nodules, thyroid fine needle aspiration biopsy (FNA) presents unique challenges for molecular assays, including contaminati
Autor:
Yoshihiko Murata, Tomoki Nakagawa, Yunjung Kim, Junko Kano, Masayuki Noguchi, Zeinab Kosibaty, Noriaki Sakamoto
Publikováno v:
Pathology International
The expression of Ras-specific guanine nucleotide-releasing factor 2 (RasGRF2) in lung adenocarcinomas was examined using immunohistochemistry in relation to clinicopathological characteristics and prognosis. In comparison to low expression, high exp
Autor:
Kyohei Yamada, Hiroaki Miyoshi, Naoko Asano, Joji Shimono, Masao Seto, Kensaku Sato, Noriaki Yoshida, Mai Takeuchi, Kazutaka Nakashima, Eriko Yanagida, Koichi Ohshima, Fumiko Arakawa
Publikováno v:
Modern Pathology. 34:314-326
Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell leukemia virus type 1 (HTLV-1). HTLV-1-associated mRNA, including HBZ and tax, is deeply involved in the pathogenesis of ATLL. Using 88 ATLL tissue samples, we performed in situ mRNA ana
Autor:
Anca Maria Cimpean, Tommaso Ciro Camerota, Marius Raica, Amalia Raluca Ceausu, Michele Mazzanti, Tiberiu Gabriel Adelmann
Publikováno v:
Anticancer Research. 40:6879-6884
Background/aim Invasive bladder cancer mortality remains high despite progresses made in early diagnosis and surgical procedures. Thus, there is a need to define new markers for bladder cancer. CLIC1 has not been previously studied in bladder cancer
Autor:
Francesca Grobelny, Christian Wülfing, Cord Matthies, Arlo Radtke, Jacqueline Bodes, Gazanfer Belge, Klaus-Peter Dieckmann
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose Serum levels of microRNA-371a-3p (M371) have been shown to be a highly sensitive and specific biomarker for testicular germ cell tumours (TGCT). Little information exists on the expression of this marker in testicular neoplasms deriving from
Autor:
Shinji Sasada, Yuichiro Ohe, Ryuta Fukai, Toshiyuki Nakai, Yuji Matsumoto, Midori Tanaka, Tomoki Nishida, Shun-ichi Watanabe, Noriko Motoi
Publikováno v:
Japanese Journal of Clinical Oncology. 51:271-278
Background Precision medicine in non-small cell lung cancer requires attainment of a sufficient amount of high-quality tumor tissue. Transbronchial cryobiopsy has emerged as a new diagnostic method for non-neoplastic lung disease with a better potent