Zobrazeno 1 - 10
of 232
pro vyhledávání: ''
Autor:
Yan-Fen Feng, Ling Deng, Hai-Yun Wang, Ying-Qing Li, Tao Tang, Fang Wang, Ya-Kang Long, Xin-Hua Yang, Xiao Zhang, Yuan He, Xu Zhang
Publikováno v:
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Purpose Current variability in methods for tumor mutational burden (TMB) estimation and reporting demonstrates the urgent need for a homogeneous TMB assessment approach. Here, we compared TMB distributions in different cancer types using two customiz
Autor:
Tomoki Taki, Yoshie Murakami, Satoko Imai, Aoi Ebata, Masashi Akiyama, Honami Akanabe, Toru Urata, Shoichiro Mori, Kenji Yokota, Mao Okumura
Publikováno v:
Cancer Science
Angiosarcoma of the head and neck (ASHN) is one of the most aggressive malignancies of the skin, but the prognostic factors are not well known because of its rarity. Recently, high plasma fibrinogen levels were reported to predict poor prognosis in s
Autor:
Mary P. Bronner, David A. Nix, Kajsa E. Affolter, Ignacio Garrido-Laguna, Courtney L. Scaife, Sean J. Mulvihill, Carrie L. Fuertes, Hunter R Underhill, Sabine Hellwig, Alun Thomas, Cindy Hamil
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 859-869 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 9, Pp 859-869 (2021)
The confounding effects of next-generation sequencing (NGS) noise on detection of low frequency circulating tumor DNA (ctDNA) without a priori knowledge of solid tumor mutations has limited the applications of circulating cell-free DNA (ccfDNA) in cl
Autor:
Albert Llansana, Albert Pujol, Maria Casasayas, M. Camacho, María del Prado Venegas, Miquel Quer, Constanza Bulboa, Xavier León
Publikováno v:
Clinical & Translational Oncology
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Purpose To analyse the relationship between the transcriptional expression of Kruppel-like factor-6 (KLF6) and local response to treatment with radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC). Methods We determined the tra
Autor:
Edward Giovannucci, Kana Wu, Amit Joshi, Dong Hang, Andrew T. Chan, Mingyang Song, Shuji Ogino, Zhe Fang, Kai Wang
Publikováno v:
International Journal of Cancer. 149:1021-1030
Most risk prediction models for colorectal cancer (CRC) are based on questionnaires and show a modest discriminatory ability. Therefore, we aim to develop risk prediction models incorporating plasma biomarkers for CRC to improve discrimination. We as
Autor:
Xiaoting Wei, Bixia Tang, Caili Li, Lin Wu, Lu Si, Xieqiao Yan, Bin Lian, Xinan Sheng, Zhihong Chi, Lili Mao, Xuan Wang, Yabin Cao, Jie Dai, Jun Guo, Yanxiang Zhang, Yan Kong, Zhonghui Qi, Li Zhou, Siming Li, Xue Bai, Chuanliang Cui
Publikováno v:
European Journal of Cancer. 148:297-306
Background Genetic aberrations in the cyclin-dependent kinase (CDK)4 pathway occur in 82% of patients with acral melanoma (AM), which is the predominant subtype of melanoma in China. We aimed to evaluate the anti-tumour activity of palbociclib, a sel
Autor:
Bruce W. Eckloff, Rory A. Jackson, Mazen A. Atiq, Sarah E. Kerr, Margaret A. DiGuardo, Asha Nair, Kevin C. Halling, Jin Jen, Kandelaria M. Rumilla, Jesse S. Voss, Rondell P. Graham, Jaime I. Davila, Andrew M. Bellizzi, Benjamin R. Kipp, Numrah Fadra, Kay Minn, Dora Lam-Himlin, Shannon M. Knight, Shabnam Zarei, Joseph H. Blommel, Robert B. Jenkins
Publikováno v:
The Journal of Molecular Diagnostics. 23:555-564
Tumor mutation burden (TMB) is an emerging biomarker of immunotherapy response. RNA sequencing in FFPE tissue samples was used for determining TMB in microsatellite-stable (MSS) and microsatellite instability–high (MSI-H) tumors in patients with co
Autor:
Peng Wei, Ying Wang, Donjeta Gjuka, Jing Wang, Jorge A. Marrero, Jingjing Jiao, Laura Beretta, Hashem B. El-Serag, Xiaoling Song, Ilvira M. Khan
Publikováno v:
Cancer Prev Res (Phila)
Novel biomarkers for hepatocellular carcinoma (HCC) surveillance in patients with cirrhosis are urgently needed. We previously identified osteopontin (OPN) as a promising biomarker for the early detection of HCC. This study is to further validate the
Publikováno v:
Carcinogenesis
Despite advances in molecular characterization of glioblastoma multiforme (GBM), only a handful of predictive biomarkers exist with limited clinical relevance. We aimed to identify differentially expressed genes in tumor samples collected at surgery
Autor:
Takahiro Kodama, Yuta Myojin, Daisuke Motooka, Yu Sato, Ayumu Taguchi, Ryotaro Sakamori, Kazuki Maesaka, Satoshi Tanaka, Tetsuo Takehara, Kazuyoshi Ohkawa, Hayato Hikita, Tomohide Tatsumi, Yoshito Hayashi, Hidetoshi Eguchi, Yuichi Abe, Eiji Mita
Publikováno v:
Clinical Cancer Research. 27:1150-1161
Purpose: Hepatocellular carcinoma (HCC) is characterized by high intertumor heterogeneity of genetic drivers. Two multitarget tyrosine kinase inhibitors (TKI), lenvatinib and sorafenib, are used as standard-of-care chemotherapeutics in patients with