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Autor:
Sebastian F. Schoppmann, Emmanuella Guenova, Gerd Jomrich, Matthias Preusser, Robin Ristl, Dariga Ramazanova, Aysegül Ilhan-Mutlu, Richard Grose, Christina Fassnacht, Dagmar Kollmann, Yi-Chien Tsai
Publikováno v:
European Journal of Surgical Oncology. 48:383-390
The effects of cytotoxic chemotherapy on the expression of programmed cell death 1 (PD-1) and its ligand (PD-L1) in cancer cells and peritumoral cells are unclear. The aim of this study was to investigate the impact of neoadjuvant chemotherapy on PD-
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 148:565-575
Purpose: NRAS plays a pivotal role in progression of various kinds of somatic malignancies; however, the correlation between NRAS and lung adenocarcinoma is less known. We aim to analyze the prognostic value of NRAS expression in lung adenocarcinoma,
Autor:
Atsushi Itou, Naoya Nakamura, Joaquim Carreras, Sawako Shiraiwa, Kiyoshi Ando, Sakura Tomita, Masashi Miyaoka, Haruka Ikoma, Yara Yukie Kikuti
Publikováno v:
Pathology International. 72:35-42
Diffuse large B-cell lymphoma with MYC rearrangement is defined as double/triple-hit lymphoma (DHL/THL) or single-hit lymphoma (SHL) by the inclusion of the BCL2 and BCL6 rearrangements status. DHL/THL is called as "high-grade B-cell lymphoma with MY
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 2, Pp 10891-10904 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 2, Pp 10891-10904 (2021)
Clear cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors worldwide. The clinical treatment of ccRCC is strongly associated with the tumor microenvironment (TME). Identifying potential markers of ccRCC is important to improve
Autor:
Katsuhiko Shimizu, Yuji Nojima, Takeshi Kurosaki, Shinsuke Saisho, Mikio Oka, Toru Oga, Koji Kurose, Masao Nakata, Ai Maeda
Publikováno v:
Anticancer Research. 41:5469-5475
Background/aim We evaluated the efficacy of "the tumor immune microenvironment (TIME) classification" for predicting clinical response to immune checkpoint inhibitors (ICIs) in patients with non-small cell lung cancer (NSCLC). In addition, we aimed t
Publikováno v:
The American Journal of Dermatopathology. 43:e141-e145
Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase pathway activation has recently been found to be associated with almost all Langerhans cell histiocytosis cases. In BRAF V600E mutation-positive cases, this activation is s
Publikováno v:
Histopathology. 79:1087-1098
Background and aims Proliferation is an important indicator of breast cancer (BC) prognosis, but is assessed using different approaches. Not all cells in the cell cycle are committed to division. This study aimed to characterise quantitative differen
Autor:
Junichi Ikeda, Takashi Yoshida, Chisato Ohe, Hidefumi Kinoshita, Koji Tsuta, Haruyuki Ohsugi, Motohiko Sugi
Publikováno v:
Anticancer Research. 41:4577-4586
Background/aim Expression of programmed death ligand-1 (PD-L1) is associated with poor prognosis in renal cell carcinoma (RCC). Although a new antibody clone for immunohistochemical assay, 73-10, has shown greater sensitivity than other assays (28-8,
Autor:
Elise Ferrand, Georgia Karpathiou, Alexandra Papoudou-Bai, Jean Marc Dumollard, Silvia-Maria Babiuc, Michel Peoc'h, Jerome Cornillon, Florian Camy
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 80:830-834
The signal transducer and activator of transcription 6 (STAT6) is implicated in the pathogenesis of some lymphomas including primary central nervous system lymphomas (PCNSLs). The aim of this study was to investigate STAT6 expression and clinicopatho
Autor:
Feng Gao, Shirong Huang, Guozhong Liu, Wei Lian, Sheng Zhang, Xiangqun Fan, Yujia Guo, Qicai Liu, Xiaoting Lv, Fadian Ding, Jingwen Wang
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Calcitonin gene-related peptide (CGRP) plays a diverse and intricate role in chronic low-grade inflammation and is closely related to specific cancers. It includes two subtypes, CALCA (αCGRP) and CALCB (βCGRP), of which αCGRP expression accounts f