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Publikováno v:
Breast Cancer Res Treat
PURPOSE: Aging associated with progressive declines in physical function is well-known; however, little is known about the trajectories of physical function before and after breast cancer diagnosis. The current study examined the trajectories in obje
Autor:
Julie Means-Powell, Luis Del Valle, Vandana G. Abramson, Claudia Sorrentino, Melinda Sanders, Ingrid A. Mayer, Debra A. Tonetti, Roohi Ismail-Khan, Samarpan Majumder, Richard M Lush, Lucio Miele
Publikováno v:
Clin Breast Cancer
Preclinical studies have demonstrated a complex cross-talk between Notch and estrogen signaling in ERα-positive breast cancer. Gamma-secretase inhibitors (GSIs) are investigational agents that block the cleavage and activation of Notch receptors. In
Autor:
Ning Zhang, Jun Zhou, Li Mei, Jie Tan, Qianzhi Chen, Yuyin Liu, Ming Xu, Shengnan Ruan, Peng-Fei Yi
Publikováno v:
Clinical Breast Cancer
The coronavirus disease 2019 (COVID-19) pandemic is a global public health event. Wuhan used to be the epicenter of China and finally controlled the outbreak through city lockdown and many other policies. However, the pandemic and the prevention stra
Autor:
Jeanne S. Mandelblatt, Martine Extermann, Tim A. Ahles, Judith E. Carroll, Kathleen Van Dyk, Harvey J. Cohen, Wanting Zhai, Deena Graham, Brent J. Small, Marie Lange, Florence Joly, James C. Root, Brenna C. McDonald, Heather S.L. Jim, Xingtao Zhou, Andrew J. Saykin, Jaeil Ahn, Natacha Heutte, Sunita K. Patel
Publikováno v:
Breast Cancer Res Treat
PURPOSE: Older cancer patients are susceptible to long-term effects of chemotherapy, including cancer-related cognitive decline and impairments to quality of life. Taxane-based chemotherapies are associated with physical declines among older women an
Autor:
Yael Schenker, Michael G. Cohen, Robert M. Arnold, Andrew D. Althouse, Kenneth J. Smith, Edward Chu, Margaret Rosenzweig, Hailey W. Bulls, Douglas B. White
Publikováno v:
Cancer
Background Clinicians often cite a fear of giving up hope as a reason they defer advance care planning (ACP) among patients with advanced cancer. The objective of this study was to determine whether engagement in ACP affects hope in these patients. M
Autor:
Audree B Tadros, Monica Morrow, Kate R Pawloski, Hannah Y Wen, Kelly Abbate, Mithat Gonen, Mahmoud El-Tamer, Donna Thompson
Publikováno v:
Breast Cancer Res Treat
PURPOSE. Routine use of the Oncotype DX Recurrence Score (RS) in patients with early-stage, estrogen receptor-positive, HER2-negative (ER+/HER2−) breast cancer is limited internationally by cost and availability. We created a supervised machine lea
Autor:
Nancy Chan, Jiuping Ji, Antoinette R. Tan, Janice M. Mehnert, Alice P. Chen, Jan H. Beumer, Mansi Shah, Joseph Aisner, Murugesan Gounder, Jyoti Malhotra, Rebecca A. Moss, Yong Lin, Brian F. Kiesel, Hongxia Lin, Mark N. Stein, Michael P. Kane
Publikováno v:
Cancer Chemother Pharmacol
Purpose Veliparib (V), an oral poly(ADP-ribose) polymerase (PARP) inhibitor, potentiates effects of alkylating agents and topoisomerase inhibitors in preclinical tumor models. We conducted a phase I trial of V with iv cyclophosphamide (C) and V plus
Publikováno v:
Int J Cancer
High nut consumption is associated with reduced total and certain cause-specific mortality in general populations. However, its association with cancer outcomes among long-term breast cancer survivors remains unknown. We examined the associations of
Autor:
Shalin J. Shah, Emily Grade, Elizabeth S. Bloom, Wendy A. Woodward, Benjamin Smith, Isidora Arzu, Julius K. Weng, Xiudong Lei, Pamela J. Schlembach, Karen E. Hoffman, Gabriel N. Hortobagyi, Michael C. Stauder, Gregory M. Chronowski, Valerie Klairisa Reed, Thomas A. Buchholz, Welela Tereffe, Kelly K. Hunt, Eric A. Strom, George H. Perkins, Simona F. Shaitelman, Tomas Dvorak
Publikováno v:
Int J Radiat Oncol Biol Phys
PURPOSE: There are limited prospective data on predictors of patient-reported outcomes (PROs) after whole-breast irradiation (WBI) plus a boost. We sought to characterize longitudinal PROs and cosmesis in a randomized trial comparing conventionally f
Autor:
Gabrielle B. Rocque, Nicole E. Caston, Risha Gidwani, Andres Azuero, Jeffrey Franks, Monica S. Aswani, Courtney P. Williams
Publikováno v:
Breast Cancer Res Treat
PURPOSE: The extent to which evidence-based treatments are applied to populations not well represented in early stage breast cancer (EBC) trials remains unknown. This study evaluated treatment intensity for patients traditionally well represented, un