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pro vyhledávání: ''
Autor:
Ashish Panigrahi, Constantine S. Tam, Piers Blombery, Xiangting Chen, John F. Seymour, Dennis A. Carney, Andrew H. Wei, Thomas E Lew, Mary Ann Anderson, Andrew W. Roberts, Ella R. Thompson, David C. S. Huang, Tamia Nguyen, David Westerman, Michael A. Dengler, Victor S Lin, Sasanka M. Handunnetti, Jerry M. Adams
Publikováno v:
Blood. 139:1198-1207
The BCL2 inhibitor venetoclax has established therapeutic roles in chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). As BCL2 is an important determinant of survival of both myeloid progenitor and B cells, we investigated whether cl
Autor:
Ryusaku Matsumoto, Masaaki Yamamoto, Genzo Iguchi, Shin Urai, Hidenori Fukuoka, Wataru Ogawa, Kentaro Suda, Hiroki Shichi, Keitaro Kanie, Yutaka Takahashi, Hironori Bando, Yasunori Fujita
Publikováno v:
Cancer Immunology, Immunotherapy
Background Immune checkpoint inhibitors (ICIs) as a cancer immunotherapy have emerged as a treatment for multiple advanced cancer types. Because of enhanced immune responses, immune-related adverse events (irAEs), including endocrinopathies such as h
Autor:
Jinping Gao, Gang Chen, Yujun Sheng, Xing Fan, Ze Guo, Liangdan Sun, He Huang, Xianfa Tang, Hui Cheng, Huayang Tang, Xiaodong Zheng, Wenjun Wang
Publikováno v:
Immunology Letters. 240:98-105
Psoriasis is an immune-mediated genetic disease involving innate and the adaptive immune system. Aurora kinase A (AURKA) belongs to a seine/threonine kinases family and is elevated in lesional psoriatic tissues. This research aimed to investigate the
Autor:
Eva Karamitopoulou, Aurélie Pahud de Mortanges, Aurel Perren, Beat Gloor, Andreas Andreou, Marianne Tinguely
Publikováno v:
Cancer Immunology Research. 9:1439-1450
Immunotherapy, including PD-1/PD-L1 agonists, has shown limited efficacy in pancreatic ductal adenocarcinoma (PDAC). We examined the PD-1/PD-L1 expression and immunoarchitectural features by automated morphometric analysis using multiplex immunofluor
Autor:
Tevriz Dilan Demir, Ayca Sayi-Yazgan, Umit Ince, Sinem Oktem-Okullu, Nogayhan Seymen, Arzu Tiftikçi, Nurdan Tözün, Ugur Sezerman, Sawsan Sudqi Said, Fatma Tokat, Elif Merve Aydın, Bahattin Çiçek
Publikováno v:
Immunology Letters. 239:1-11
Background The progression to gastric cancer has been linked to chronic infection with Helicobacter pylori (H. pylori). Immune checkpoint inhibitors (programmed cell death -1, PD-1; programmed cell death –ligand 1, PD-L1) have a role in cancer immu
Autor:
Babak PeyroShabany, Mansoureh Dehghani, Seyed Alireza Javadinia, Danial Fazilat-Panah, Pejman Porouhan, Farbod Hatami, James S Welsh, Maryam Nabavifard, Mona Ariamanesh, Mohammad Fereidouni
Publikováno v:
Cancer Investigation
article-version (VoR) Version of Record
article-version (VoR) Version of Record
ObjectivePatients with malignancy suffer from a compromised immune system due to either the effects of malignancies or treatments. Cancer patients are at higher risk of different infections particularly SARS-CoV2 and usually produce weaker response t
Autor:
Morie A. Gertz, Yi Lisa Hwa, Stephen J. Russell, David Dingli, Taxiarchis Kourelis, Wilson I. Gonsalves, Shaji Kumar, Eli Muchtar, Robert A. Kyle, Rahma Warsame, Francis K. Buadi, Mustaqeem A. Siddiqui, Nelson Leung, Prashant Kapoor, Suzanne R. Hayman, Amie Fonder, Moritz Binder, S. Vincent Rajkumar, Miriam Hobbs, Yi Lin, Martha Q. Lacy, Bharat Nandakumar, Angela Dispenzieri
Publikováno v:
Leukemia. 36:801-808
Background: There has been a steady improvement in the survival of patients with multiple myeloma (MM) due to better understanding of the pathophysiology, use of novel agents, and risk-adapted therapy. These improvements were largely observed in clin
Autor:
Ben Barron-Millar, Andrew L. Mellor, Henrique Lemos, John D. Isaacs, Nicola J. Maney, Christopher D. Carey, Amy E. Anderson, Ian Herron, Arthur G. Pratt
Publikováno v:
Arthritis & Rheumatology. 73:1820-1830
Objective As well as being an established oncoprotein and therapeutic target in cancer, proviral integration site for Moloney murine leukemia virus 1 (Pim-1) is implicated in human autoimmunity. This study was undertaken to investigate Pim-1 and its
Publikováno v:
Leukemia
Autor:
William Rodin, Bengt Gustavsson, Louis Szeponik, Marianne Quiding-Järbrink, Patrik Sundström, Yvonne Wettergren, Elinor Bexe Lindskog, Filip Ahlmanner
Publikováno v:
BMC Immunology, Vol 22, Iss 1, Pp 1-12 (2021)
BMC Immunology
BMC Immunology
Background Intratumoral regulatory T cells (Treg) in colon cancer are a heterogeneous cell population, with potential impact on patient outcome. Generally, a high Treg infiltration has been correlated to a worse patient outcome, but it is still uncle