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Autor:
Jinjing Zhong, Miao Xu, Zhengzheng Su, Mengni Zhang, Tianping Yu, Ling Nie, Jing Gong, Xueqin Chen, Ni Chen, Qiao Zhou
Publikováno v:
Cancer Letters. 530:68-84
Glioma-associated oncogene homolog 1 (GLI1) is a core component of the Hedgehog (HH) signalling pathway and is a transcription activator of numerous oncogenes, such as SOX9, VEGFA, BCL2, and CDK2. The complex regulation of GLI1 involves numerous path
Publikováno v:
Anticancer Research. 42:1301-1306
Background/aim: Functional and bioinformatic studies provide strong evidence that long non-coding RNAs (lncRNAs) can alter the molecular mechanisms of cancer through their interactions with DNA, RNAs, and proteins. This study aimed to evaluate the ro
Autor:
Yu-Zhong Yu, Dao-Jun Lv, Chong Wang, Xian-Lu Song, Tao Xie, Tao Wang, Zhi-Min Li, Jia-Ding Guo, Du-Jiang Fu, Kang-Jin Li, Ding-Lan Wu, Franky Leung Chan, Ning-Han Feng, Zhe-Sheng Chen, Shan-Chao Zhao
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-21 (2022)
Molecular Cancer
Molecular Cancer
Background More and more studies have shown that circular RNAs (circRNAs) play a critical regulatory role in many cancers. However, the potential molecular mechanism of circRNAs in prostate cancer (PCa) remains largely unknown. Methods Differentially
Autor:
Yukyung Jun, Yun-Suhk Suh, SungHee Park, Jieun Lee, Jong-Il Kim, Sanghyuk Lee, Wan-Ping Lee, Olga Anczuków, Han-Kwang Yang, Charles Lee
Publikováno v:
Cancer Research. 82:543-555
Alternatively spliced RNA isoforms are a hallmark of tumors, but their nature, prevalence, and clinical implications in gastric cancer have not been comprehensively characterized. We systematically profiled the splicing landscape of 83 gastric tumors
Autor:
Min Deng, Jia-Bao Lin, Rong-Ce Zhao, Shao-Hua Li, Wen-Ping Lin, Jing-Wen Zou, Wei Wei, Rong-Ping Guo
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
BMC Cancer
BMC Cancer
Background The accuracy of existing biomarkers for predicting the prognosis of hepatocellular carcinoma (HCC) is not satisfactory. It is necessary to explore biomarkers that can accurately predict the prognosis of HCC. Methods In this study, original
Autor:
Shingo Yamamoto, Yusuke Yamada, Yoshie Yoshikawa, Akihiro Kanematsu, Mitsuru Emi, Yukako Nakanishi-Shinkai, Karel de Groot, Tomoko Hashimoto-Tamaoki, Jan Smout, Suvi Savola, Michio Nojima, Lilit Atanesyan, Masaki Ohmuraya
Publikováno v:
Cancer Science
Precise quantification of copy‐number alterations (CNAs) in a tumor genome is difficult. We have applied a comprehensive copy‐number analysis method, digital multiplex ligation‐dependent probe amplification (digitalMLPA), for targeted gene copy
Autor:
Kohei Shigeta, Ryo Seishima, Yusuke Asada, Yuko Kitagawa, Masashi Tsuruta, Shingo Akimoto, Koji Okabayashi, Osamu Itano, Takashi Ishida, Hirotoshi Hasegawa, Kaoru Koishikawa, Takehiro Shimada, Hirofumi Suzumura
Publikováno v:
Anticancer Research. 41:5445-5452
Background/aim The role of brahma-related gene 1 (BRG1)-associated factor 57 (BAF57), a transcription factor, has been determined in prostate, breast, and ovarian cancer. However, the relationship between BAF57 and colorectal cancer (CRC) is obscure.
Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma
Autor:
Atsushi Kurata, Akihiko Gotoh, Masakatsu Takanashi, Masahiko Kuroda, Keiki Oikawa, Jun Matsubayashi, Kohsuke Kanekura, Toshitaka Nagao, Koji Fujita, Daigo Akahane, Narangerel Jigjidkhorloo, Oyundelger Norov, Hitoshi Endou
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
L-type neutral amino acid transporter 1 (LAT1) is a heterodimeric membrane transport protein involved in neutral amino acid transport. LAT1 is highly expressed in various malignant solid tumors and plays an essential role in cell proliferation. Howev
Autor:
Danhua Wang, Jinku Zhang, Bobo Li, Dezhi Cheng, Minke Shi, Weiran Wang, Tonghui Ma, Sizhen Wang, Dongxiao Lv
Publikováno v:
Cancer Science
Fusion of RET with different partner genes has been detected in papillary thyroid, lung, colorectal, pancreatic, and breast cancer. Approval of selpercatinib for treatment of lung and thyroid cancer with RET gene mutations or fusions calls for studie
Publikováno v:
Future Oncology. 17:4527-4543
Background: The role of HGF in squamous cell carcinoma of the head and neck (SCCHN) is not clear. Methods: Reverse transcription PCR, western blotting, gelatin zymography, immunohistochemistry, actin polymerization, chemotaxis and migration assays we