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Publikováno v:
Human Pathology. 119:51-58
Oncogenic mutations in the adenomatous polyposis coli (APC)/Wnt signaling pathway are well documented. The FBXW7 gene (F-box and WD repeat domain-containing 7) encodes a member of the ubiquitin-proteasome complex that is more recently described to an
Autor:
Akira Sasaki, Tamotsu Sugai, Takayuki Matsumoto, Mitsumasa Osakabe, Hiromu Suzuki, Naoki Yanagawa, Shun Yamada, Koki Otsuka, Makoto Eizuka, Yoshihito Tanaka, Takeshi Niinuma
Publikováno v:
Genes, Chromosomes and Cancer. 61:161-171
MicroRNA (miRNA) expression is dysregulated in human tumors, thereby contributing to tumorigenesis through altered expression of mRNA. Thus, identification of the relationships between miRNAs and mRNAs is important for evaluating the molecular mechan
Autor:
Ryusaku Matsumoto, Masaaki Yamamoto, Genzo Iguchi, Shin Urai, Hidenori Fukuoka, Wataru Ogawa, Kentaro Suda, Hiroki Shichi, Keitaro Kanie, Yutaka Takahashi, Hironori Bando, Yasunori Fujita
Publikováno v:
Cancer Immunology, Immunotherapy
Background Immune checkpoint inhibitors (ICIs) as a cancer immunotherapy have emerged as a treatment for multiple advanced cancer types. Because of enhanced immune responses, immune-related adverse events (irAEs), including endocrinopathies such as h
Autor:
Rainer Heuchel, Béla Bozóky, Benedek Bozoky, Marco Gerling, Carina Strell, Ingemar Ernberg, J.-Matthias Löhr, Laszlo Szekely, Natalie Geyer, Carlos Fernández Moro
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1300-1306 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Highlights • PDAC cells in the duodenal epithelium mimic intestinal cells and co-opt the basement membrane. • Intramucosal PDAC location is strongly coupled to the classical phenotype and to intestinal traits. • Intratumoral heterogeneity is li
Autor:
Eva Karamitopoulou, Aurélie Pahud de Mortanges, Aurel Perren, Beat Gloor, Andreas Andreou, Marianne Tinguely
Publikováno v:
Cancer Immunology Research. 9:1439-1450
Immunotherapy, including PD-1/PD-L1 agonists, has shown limited efficacy in pancreatic ductal adenocarcinoma (PDAC). We examined the PD-1/PD-L1 expression and immunoarchitectural features by automated morphometric analysis using multiplex immunofluor
Publikováno v:
Turk J Gastroenterol
BACKGROUND: Considering the difficulty in predicting the biological behavior of gastrointestinal stromal tumors (GISTs) based on histological findings alone, genetic abnormalities have recently become an area of focus. Platelet-derived growth factor
Autor:
Xiangjun Xiao, James McKay, Yanhong Liu, David C. Christiani, Rayjean J. Hung, Chao Cheng, Wei Hong, John K. Field, Ang Li, Christopher I. Amos
Publikováno v:
Cancer Res
Clonal hematopoiesis (CH) is a phenomenon caused by expansion of white blood cells descended from a single hematopoietic stem cell. While CH can be associated with leukemia and some solid tumors, the relationship between CH and lung cancer remains la
Autor:
Fatemeh Taheri, Soheila Fattahi, Mahdi Ghatrehsamani, Maryam Anjomshoa, Faramarz Mohammad Alibeigi, Nader Bagheri, Hedayatollah Shirzad, Monireh Karimi
Publikováno v:
Int J Exp Pathol
Bladder cancer (BC) is one of the most prevalent cancers around the world and, if not treated well, has high morbidity and mortality. Many studies have indicated that there may be various roles for the aryl hydrocarbon receptor (AHR) in the immune sy
Autor:
Atsushi Itou, Naoya Nakamura, Joaquim Carreras, Sawako Shiraiwa, Kiyoshi Ando, Sakura Tomita, Masashi Miyaoka, Haruka Ikoma, Yara Yukie Kikuti
Publikováno v:
Pathology International. 72:35-42
Diffuse large B-cell lymphoma with MYC rearrangement is defined as double/triple-hit lymphoma (DHL/THL) or single-hit lymphoma (SHL) by the inclusion of the BCL2 and BCL6 rearrangements status. DHL/THL is called as "high-grade B-cell lymphoma with MY
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 24, Pp 8934-8943 (2021)
Cancer Medicine, Vol 10, Iss 24, Pp 8934-8943 (2021)
Background Many real‐world studies of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) are restricted to single centers, limiting the generalizability of their insights. This study aimed to identify important population‐based pre