Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mark Harbinson"'
Publikováno v:
Peptides. 76:19-29
Intermedin/adrenomedullin-2 (IMD) is a member of the adrenomedullin/CGRP peptide family. Less is known about the distribution of IMD than for other family members within the mammalian cardiovascular system, particularly in humans. The aim was to eval
Autor:
Aaron McCann, Paul Hamilton, R. A. Pinnock, Christopher J. Lockhart, Mark Harbinson, Gary E. McVeigh
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 307:H1729-H1736
Structural and functional changes in the microcirculation in type 1 diabetes mellitus predict future end-organ damage and macrovascular events. We explored the utility of novel signal processing techniques to detect and track changes in ocular hemody
Autor:
Mark Harbinson, Christopher J. Lockhart, Aaron McCann, R. C. McGivern, Paul Hamilton, Christina E. Agnew, Vivienne McClenaghan, C. Bleakley, Gary E. McVeigh
Publikováno v:
QJM. 104:589-597
Background: Flow-mediated dilatation (FMD) of the brachial artery is commonly measured as a surrogate marker of endothelial function. Its measurement is, however, technically demanding and reports regarding its reproducibility have not always been fa
Publikováno v:
The Canadian journal of cardiology. 31(12)
Statins are among the most investigated drugs of all time. There is now a wealth of evidence supporting their use in the primary and secondary prevention arenas. The reduction in event recurrence has since been demonstrated across all levels of risk
Autor:
Caroline, Bleakley, Aaron, McCann, Vivienne, McClenaghan, Paul Kevin, Hamilton, Auleen, Millar, Richard, Pumb, Mark, Harbinson, Gary Eugene, McVeigh
Publikováno v:
Cardiovascular Ultrasound
Background The identification of pre-clinical microvascular damage in hypertension by non-invasive techniques has proved frustrating for clinicians. This proof of concept study investigated whether entropy, a novel summary measure for characterizing
Autor:
David, Bell, Malcolm, Campbell, Matthew, Ferguson, Leah, Sayers, Liz, Donaghy, Anna, O'Regan, Victoria, Jewhurst, Mark, Harbinson
Publikováno v:
The Journal of physiology. 590(5)
Intermedin (IMD) protects rodent heart and vasculature from oxidative stress and ischaemia. Less is known about distribution of IMD and its receptors and the potential for similar protection in man. Expression of IMD and receptor components were stud
Autor:
Christopher J. Lockhart, Vivienne McClenaghan, R. Canice McGivern, Cathy E. Quinn, Paul Hamilton, Mark Harbinson, Christina A Agnew, Aaron McCann, Christopher Patterson, Gary E. McVeigh
Publikováno v:
Lockhart, C J, McCann, A, Agnew, C A, Hamilton, P K, Quinn, C E, McClenaghan, V, Patterson, C, McGivern, R C, Harbinson, M T & McVeigh, G E 2011, ' Impaired microvascular properties in uncomplicated type 1 diabetes identified by Doppler ultrasound of the ocular circulation ', Diabetes and Vascular Disease Research, vol. 8, no. 3, pp. 211-220 . https://doi.org/10.1177/1479164111411324
Objective: Quantification of Doppler flow velocity waveforms has been shown to predict adverse cardiovascular outcomes and identify altered downstream haemodynamics and vascular damage in a number of organ beds. We employed novel techniques to quanti
Autor:
Vivienne McClenaghan, Christina E. Agnew, Damien O. McCall, Christopher J. Lockhart, Paul Hamilton, R. Canice McGivern, Gary E. McVeigh, Richard Plumb, Cathy E. Quinn, Aaron McCann, Mark Harbinson
Publikováno v:
Clinical science (London, England : 1979). 121(3)
Impaired FMD (flow-mediated dilatation) has traditionally been recognized as an indirect marker of NO bioactivity, occurring in disease states such as DM (diabetes mellitus). Endothelium-dependent FMD is a homoeostatic response to short-term increase
Autor:
Sinead M. Hughes, Richard Plumb, R. Canice McGivern, Andrew J. Gamble, Mark Harbinson, Derrick J. Rea, Christopher J. Lockhart, Gary E. McVeigh, Michael Stevenson, Clive Wolsley
Publikováno v:
Clinical science (London, England : 1979). 111(1)
Quantitative analysis of the arterial pressure pulse waveform recorded by applanation tonometry of the radial artery can track NO (nitric oxide)-mediated modulation of arterial smooth muscle tone. The changes in pressure pulse waveform morphology res