Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Richard A, Koup"'
Autor:
Rajendra Pahwa, Varghese K. George, David Huddleston, David R. Ambrozak, Suresh Pallikkuth, Lesley R. de Armas, Savita Pahwa, Louis Gonzalez, Richard A. Koup, Constantinos Petrovas, Eirini Moysi
Publikováno v:
The Journal of clinical investigation. 128(7)
HIV infection changes the lymph node (LN) tissue architecture, potentially impairing the immunologic response to antigenic challenge. The tissue-resident immune cell dynamics in virologically suppressed HIV+ patients on combination antiretroviral the
Autor:
Marlous L. Grijsen, John R. Mascola, Rebecca M. Lynch, Adam K. Wheatley, Jan M. Prins, Richard A. Koup, Madhu Prabhakaran, Godelieve J. de Bree, Adrian B. McDermott, Stephen D. Schmidt
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
PLoS ONE, Vol 12, Iss 3, p e0173577 (2017)
PLoS ONE, 12(3). Public Library of Science
Background Neutralizing antibodies develop in natural HIV-1 infection. Their development often takes several years and may rely on chronic virus exposure. At the same time recent studies show that treatment early in infection may provide opportunitie
Autor:
Li Li, Yan-Ying Fan, Richard A. Koup, Tao Yu, Zi-Tong Huang, Robert T. Bailer, Man-Hui Wu, Chang-You Wu
Publikováno v:
Archives of Virology
SARS-CoV infection of human results in antigen-specific cellular and humoral immune responses. However, it is critical to determine whether SARS-CoV-specific memory T cells can persist for long periods of time. In this study, we analyzed the cellular
Autor:
Jian Li, Chang-You Wu, Ling-yun Wang, Richard A. Koup, Robert T. Bailer, Li-tao Yang, Hui Peng, Zhi-qiang Lu
Publikováno v:
Microbes and Infection
E protein is a membrane component of severe acute respiratory syndrome coronavirus (SARS-CoV). Disruption of E protein may reduce viral infectivity. Thus, the SARS-CoV E protein is considered a potential target for the development of antiviral drugs.
Autor:
John Hegarty, Daniel C. Douek, Jacinta Kelly, Cliona O'Farrelly, Richard A. Koup, Lucy Golden-Mason
Publikováno v:
The Journal of Immunology. 172:5980-5985
Normal adult human liver (AHL) contains populations of unconventional lymphocytes that have been shown in the mouse to mature locally. The presence of lymphoid progenitors together with IL-7, recombinase-activating gene, and pre-TCR-α expression in
Autor:
Michael R. Betts, Stephen I. Pelton, Bruce D. Walker, Philip J. R. Goulder, Ross E. McKinney, Marcus Altfeld, Eric S. Rosenberg, Ken Annamalai, Yanhua Tang, Alicja Trocha, Spyros A. Kalams, Sandra K. Burchett, Suqin He, Richard A. Koup, Kenneth H. Mayer, Christian Brander, Christopher A. O’Callaghan, Graham S. Ogg, Kenneth McIntosh
Publikováno v:
The Journal of Experimental Medicine
The highly sensitive quantitation of virus-specific CD8+ T cells using major histocompatibility complex–peptide tetramer assays has revealed higher levels of cytotoxic T lymphocytes (CTLs) in acute and chronic virus infections than were recognized
Autor:
Richard A Koup, Mario Roederer, Laurie Lamoreaux, Jennifer Fischer, Laura Novik, Martha C Nason, Brenda D Larkin, Mary E Enama, Julie E Ledgerwood, Robert T Bailer, John R Mascola, Gary J Nabel, Barney S Graham, VRC 009 Study Team, VRC 010 Study Team
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9015 (2010)
PLoS ONE
PLoS ONE
Background Induction of HIV-1-specific T-cell responses relevant to diverse subtypes is a major goal of HIV vaccine development. Prime-boost regimens using heterologous gene-based vaccine vectors have induced potent, polyfunctional T cell responses i
Autor:
Brenna J. Hill, Daniel C. Douek, Mario Roederer, Joseph P. Casazza, Jason M. Brenchley, Michael R. Betts, Ribka Ayana, David R. Ambrozak, Richard A. Koup
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000646 (2009)
PLoS Pathogens
PLoS Pathogens
Induction of a functional subset of HIV-specific CD4+ T cells that is resistant to HIV infection could enhance immune protection and decrease the rate of HIV disease progression. CMV-specific CD4+ T cells, which are less frequently infected than HIV-
Autor:
David Price, Natalie E. R. Beveridge, Helen McShane, Adrian V. S. Hill, Mario Roederer, Tedi E. Asher, Joseph P. Casazza, Melissa L. Precopio, Phillip Scheinberg, Richard A. Koup, Clare R. Sander, Nicola Alder, David R. Ambrozak, Daniel C. Douek, Ansar A. Pathan
Publikováno v:
European journal of immunology. 37(11)
In the search for effective vaccines against intracellular pathogens such as HIV, tuberculosis and malaria, recombinant viral vectors are increasingly being used to boost previously primed T cell responses. Published data have shown prime-boost vacci
Autor:
Robert T. Bailer, Mario Roederer, Barney S. Graham, Janie Parrino, Emma Gostick, Michael R. Betts, Melissa L. Precopio, Tedi E. Asher, Richard A. Koup, David Price, Daniel C. Douek, Alexandre Harari, Giuseppe Pantaleo, David R. Ambrozak
Publikováno v:
Journal of Experimental Medicine, vol. 204, no. 6, pp. 1405-16
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Vaccinia virus immunization provides lifelong protection against smallpox, but the mechanisms of this exquisite protection are unknown. We used polychromatic flow cytometry to characterize the functional and phenotypic profile of CD8(+) T cells induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f734f56769cf681b2d2183a323e1c80a
https://serval.unil.ch/resource/serval:BIB_D1AFA81DDA61.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_D1AFA81DDA61.P001/REF.pdf