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Publikováno v:
Journal of Pediatric and Adolescent Gynecology. 35:294-298
Although multiple hormonal treatment strategies are effective in decreasing heavy menstrual bleeding (HMB) in adolescents, few studies have compared the relative effectiveness of hormone therapy on the basis of dose.Retrospective chart review SETTING
Publikováno v:
IEEE Trans Biomed Eng
Objective: Pediatric obesity predisposes children and adolescents to early onset insulin resistance and dysglycemia. In the last 20 years this has led to a rise in the prevalence of prediabetes, diabetes and fatty liver in youngsters, due to the high
Autor:
Pilar Lim, Husseini K. Manji, Rosanne Lane, Ella Daly, Wayne C. Drevets, Rachel Ochs-Ross, Carol Jamieson, David C. Steffens, Yun Zhang, Jaskaran Singh, David Hough, Gerard Sanacora, Ewa Wajs
Publikováno v:
The American Journal of Geriatric Psychiatry. 30:541-556
Background Older, compared with younger, patients with treatment-resistant depression (TRD) typically have lower response and remission rates with poorer tolerability to antidepressant treatment. This post-hoc analysis compared outcomes following tre
Autor:
Atsushi Kawakami, Keita Iyama, Seiji Koga, Hiroaki Kawano, Koji Ando, Koji Maemura, Hayato Tada, Masa-aki Kawashiri, Tsuyoshi Yoshimuta, Satoshi Ikeda, Sosuke Tsuji, Kayoko Matsushima
Publikováno v:
Internal Medicine. 61:1169-1177
A 17-year-old boy with acute coronary syndrome was admitted to our hospital. He had xanthomas over his elbow and Achilles tendon and a high level of low-density lipoprotein cholesterol; therefore, his initial diagnosis was familial hypercholesterolem
Autor:
Marilyn Owens, Ryan Solinsky, Mary Schmidt-Read, J. Andrew Taylor, Nathaniel B. Dusseau, Jan M. Schwab, Yaga Szlachcic, Linda Sutherland, Luisa Betancourt, Mark S. Nash, Mendel Kupfer
Publikováno v:
Archives of Physical Medicine and Rehabilitation. 103:696-701
To (1) describe the prevalence of cardiometabolic disease (CMD) at spinal cord injury (SCI) rehabilitation discharge; (2) compare this with controls without SCI; and (3) identify factors associated with increased CMD.Multicenter, prospective observat
Autor:
Daniel Kotlarz, Scott B. Snapper, Christoph Klein, Daniel J. Mulder, Aleixo M. Muise, Neil Warner, Dermot P.B. McGovern, Judy H. Cho, Itaru Iwama, Anne M. Griffiths, Ryusuke Nambu
Publikováno v:
Clin Gastroenterol Hepatol
BACKGROUND AND AIMS: Advances in genomic technologies have led to increasing reports of monogenic inflammatory bowel disease (IBD). However, there has not been a detailed evaluation of the characteristics of the published cases of monogenic IBD. Here
Autor:
Eduardo Garcia Vilela, Henrique Rocha
Publikováno v:
Gastroenterología y Hepatología. 45:83-90
Background and aims Inflammatory bowel diseases (IBD) are chronic conditions that may be accompanied by autoimmune liver disease (AILD), most commonly primary sclerosing cholangitis (PSC). The objective of this study was to evaluate the behaviour of
News on immune checkpoint inhibitors as immunotherapy strategies in adult and pediatric solid tumors
Publikováno v:
Seminars in Cancer Biology. 79:18-43
Immune checkpoint inhibitors (ICIs) have shown unprecedented benefits in various adult cancers, and this success has prompted the exploration of ICI therapy even in childhood malignances. Although the use of ICIs as individual agents has achieved dis
Autor:
Nitesh Sood, Andre Gauri, Kevin J. Makati, Blair D. Halperin, Gopi Dandamudi, Gustavo Morales, Oussama M. Wazni, Rachelle E Kaplon, Sarfraz Durrani, Erika Pouliot, Mingyuan Shao, Jaret Tyler, Robert S. Hoyt, Stop Af First Trial Investigators, Steven E. Nissen, Mark Niebauer
Publikováno v:
Heart Rhythm. 19:197-205
BACKGROUND The STOP AF First trial recently demonstrated that initial treatment with cryoballoon ablation (CBA) is safe and superior to antiarrhythmic drug (AAD) therapy for preventing atrial arrhythmia recurrence in patients with symptomatic atrial
Autor:
Jan Hinnerk Hansen, Patrick Langguth, Jörg Detlev Moritz, Olav Jansen, Marcus Both, Anselm Uebing, Paul Lennard Harneit, Joshua Kian Khodami, Joachim Graessner, Mona Salehi Ravesh, Katy Rinne
Publikováno v:
International Journal of Cardiology. 349:48-54
OBJECTIVES To evaluate the ability of non-contrast enhanced magnetic resonance imaging (MRI) techniques to characterize Fontan associated liver disease (FALD) in adolescent and adult Fontan patients. METHODS Fontan patients (n = 29) and healthy contr