Zobrazeno 1 - 10
of 12 568
pro vyhledávání: ''
Autor:
Shunsuke Kimura, Lindsey Montefiori, Ilaria Iacobucci, Yaqi Zhao, Qingsong Gao, Elisabeth M. Paietta, Claudia Haferlach, A. Douglas Laird, Paul E. Mead, Zhaohui Gu, Wendy Stock, Mark Litzow, Jacob M. Rowe, Selina M. Luger, Stephen P. Hunger, Georgina L. Ryland, Breon Schmidt, Paul G. Ekert, Alicia Oshlack, Sean M. Grimmond, Jacqueline Rehn, James Breen, David Yeung, Deborah L. White, Ibrahim Aldoss, Elias J. Jabbour, Ching-Hon Pui, Manja Meggendorfer, Wencke Walter, Wolfgang Kern, Torsten Haferlach, Samuel Brady, Jinghui Zhang, Kathryn G. Roberts, Piers Blombery, Charles G. Mullighan
Publikováno v:
Blood
Transcriptome sequencing has identified multiple subtypes of B-progenitor acute lymphoblastic leukemia (B-ALL) of prognostic significance, but a minority of cases lack a known genetic driver. Here, we used integrated whole-genome (WGS) and -transcrip
Autor:
Camelia Margareta, Bogdănici, Claudia Florida, Costea, Gabriela Florenţa, Dumitrescu, Anca, Sava, Delia Gabriela, Ciobanu Apostol, Dragoş Viorel, Scripcariu, Simona Delia, Nicoară, Daniela Maria, Tănase, Elena Corina, Andriescu, Alexandru, Cărăuleanu, Mihai, Danciu, Silvia Cristina, Sălăvăstru, Speranţa, Schmitzer, Andrei Ionuţ, Cucu, Irina Andreea, Niagu
Publikováno v:
Romanian Journal of Morphology and Embryology. 62:907-915
Conjunctival pigmented neoplasia can be benign, premalignant or malignant tumors. Our study aims to establish the epidemiological, gross morphological and immunohistopathological features of the conjunctival pigmented lesions in pediatric and adolesc
Autor:
Scott C. Borinstein, David Agamasu, Jonathan S. Schildcrout, Lisa Bastarache, Minoo Bagheri, Lea K. Davis, Dan M. Roden, C. Michael Stein, Sara L. Van Driest, Jonathan D. Mosley
Publikováno v:
Journal of Cellular and Molecular Medicine. 26:3628-3635
Healthy individuals in the United States identified as having Black race have lower neutrophil counts, on average, than individuals identified as having White race, which could result in more negative diagnostic evaluations for neutropenia. To test t
Publikováno v:
Virchows Archiv. 481:511-516
We report a case of primary rectal neoplasm with a novel DDX5-TFEB fusion in a 14-year-old boy. Histologically, the neoplasm was composed of epithelioid tumor cells with abundant clear to eosinophilic cytoplasm, arranged in nests with rich stromal ca
Male fertility preservation and restoration strategies for patients undergoing gonadotoxic therapies
Publikováno v:
Biology of Reproduction. 107:382-405
Medical treatments for cancers or other conditions can lead to permanent infertility. Infertility is an insidious disease that impacts not only the ability to have a biological child but also the emotional well-being of the infertile individuals, rel
Autor:
Lena Muckenthaler, Oriana Marques, Silvia Colucci, Joachim Kunz, Piotr Fabrowski, Thomas Bast, Sandro Altamura, Britta Höchsmann, Hubert Schrezenmeier, Monika Langlotz, Paulina Richter-Pechanska, Tobias Rausch, Nicole Hofmeister-Mielke, Nikolas Gunkel, Matthias W. Hentze, Andreas E. Kulozik, Martina U. Muckenthaler
Publikováno v:
Blood. 139:1418-1422
Muckenthaler et al describe a novel form of hemochromatosis caused by a constitutional PIGA mutation in 3 children with associated neurologic dysfunction. Hemochromatosis results from decreased hepcidin, which is regulated by HFE, hemojuvelin (HJV),
Autor:
Mateusz Maciejczyk, Anna Zalewska, Małgorzata Gryciuk, Katarzyna Hodun, Miłosz Czuba, Kamila Płoszczyca, Małgorzata Charmas, Jerzy Sadowski, Marcin Baranowski
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-18
Hypoxia is a recognized inducer of oxidative stress during prolonged physical activity. Nevertheless, previous studies have not systematically examined the effects of normoxia and hypoxia during acute physical exercise. The study is aimed at evaluati
Autor:
Yang Yang, Minghui Yang, Yun Peng, Yanhua Liang, Jinli Wei, Li Xing, Liping Guo, Xiaohe Li, Jie Li, Jun Wang, Mianhuan Li, Zhixiang Xu, Mingxia Zhang, Fuxiang Wang, Yi Shi, Jing Yuan, Yingxia Liu
Publikováno v:
Nature Microbiology. 7:423-433
Elucidating the dynamics of the neutralizing antibody (nAb) response in coronavirus disease 2019 (COVID-19) convalescents is crucial in controlling the pandemic and informing vaccination strategies. Here we measured nAb titres across 411 sequential p
Publikováno v:
Am J Respir Cell Mol Biol
Airway smooth muscle thickening, a key characteristic of chronic asthma, is largely attributed to increased smooth muscle cell proliferation and reduced smooth muscle apoptosis. Polo-like kinase 1 (Plk1) is a serine/threonine protein kinase that part
Autor:
Hongseok Yun, Seung Hong Choi, Ka Young Lim, Seung-Ki Kim, Yumi Shim, Tae Min Kim, Jin-Woo Park, Hyunhee Kim, Jeongwan Kang, Sung Hye Park, Chul-Kee Park, Kwanghoon Lee, Jae Kyung Won
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Mismatch repair-deficient (MMRD) brain tumors are rare among primary brain tumors and can be induced by germline or sporadic mutations. Here, we report 13 MMRD-associated (9 sporadic and 4 Lynch syndrome) primary brain tumors to determine clinicopath