Zobrazeno 81 - 90
of 18 980
pro vyhledávání: ''
Autor:
Nassim Djebli, Pierre-Olivier Tremblay, Vincent Buchheit, Mario González-Sales, Guillaume Bonnefois, Georgina Meneses-Lorente, Francois Mercier, Nicolas Frey
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:997-1007
Entrectinib (ROZLYTREK®) is a CNS-active, potent, and selective inhibitor of ROS1, TRK A/B/C, and ALK kinase activity. It was recently approved for the treatment of ROS1-positive non-small cell lung cancer and NTRK gene fusion-positive solid tumors.
Autor:
Christopher Lum, Kevin Cassel, John A. Shepherd, Janira M. Navarro Sanchez, Shane Y.P.K. Spencer, Terrilea Burnett, Mark L. Willingham
Publikováno v:
Melanoma Res
Skin cancer remains the most commonly diagnosed cancer in the USA with more than 1 million new cases each year. Melanomas account for about 1% of all skin cancers and most skin cancer deaths. Multiethnic individuals whose skin is pigmented underestim
Publikováno v:
International Journal of Cancer. 150:18-27
H. pylori (H. pylori) infection is considered the leading cause of gastric cancer. Gastric cancer is currently a common cancer with high incidence and mortality rates, but it is expected that the incidence rate will gradually decrease as the H. pylor
Autor:
Michael Thomas, Maria Palmisano, Mark Thomas, Sekhar Surapaneni, Yongjun Xue, Mary Liu, Simon Zhou, Rebecca N. Wood-Horrall, Gopal Krishna, Liangang Liu, Leonidas N Carayannopoulos, Ken Ogasawara
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:941-952
Fedratinib, an oral, selective Janus kinase 2 inhibitor, has been shown to inhibit P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), organic anion transporting polypeptide (OATP) 1B1, OATP1B3, organic cation transporter (OCT) 2, and mul
Autor:
Xavier Quantin, Nicolas Girard, Marylise Ginoux, Luc Thiberville, Benjamin Besse, Christelle Clément-Duchêne, P.A. Thomas, P. Mordant, Angela Botticella, C. Le Pechoux, J. Khalifa, Eric Pichon, Thierry Jo Molina, F. Le Tinier, Youssef Oulkhouir, Mallorie Kerjouan, Clémence Basse, Pierre Emmanuel Falcoz, F. Thillays, Virginie Westeel
Publikováno v:
Clinical Lung Cancer
Clinical Lung Cancer, Elsevier, 2021, ⟨10.1016/j.cllc.2021.01.020⟩
Clinical Lung Cancer, Elsevier, 2021, ⟨10.1016/j.cllc.2021.01.020⟩
Introduction Thymomas are rare intrathoracic malignancies that may be aggressive and difficult to treat. Knowledge and level of evidence for treatment strategies are mainly based on retrospective studies or expert opinion. Currently there is no stron
Autor:
Masahiro Tanji, Tomoko Shofuda, Susumu Miyamoto, Yoshiki Arakawa, Ema Yoshioka, Sachiko Minamiguchi, Yasuhide Makino, Masayuki Mano, Takeshi Kawauchi, Takanori Hirose, Masahiro Nonaka, Yohei Mineharu, Yoshiko Okita, Daisuke Kanematsu, Yoshinori Kodama, Yonehiro Kanemura
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021)
BMC Cancer
BMC Cancer
Background Mutations in driver genes such as IDH and BRAF have been identified in gliomas. Meanwhile, dysregulations in the p53, RB1, and MAPK and/or PI3K pathways are involved in the molecular pathogenesis of glioblastoma. RAS family genes activate
Autor:
Johannes E. A. Wolff
Publikováno v:
Anticancer Research. 41:4543-4548
Background/aim Adverse event (AE) frequencies observed in interventional clinical trials are difficult to interpret when the placebo control is missing. Materials and methods Systematic literature review of AEs reported from the placebo arms of rando
Autor:
Jun Liu, Dan-Dan Li, Wei Dong, Yu-Qi Liu, Yang Wu, Da-Xuan Tang, Fu-Chun Zhang, Meng Qiu, Qi Hua, Jing-Yu He, Jun Li, Bai Du, Ting-Hai Du, Lin-Lin Niu, Xue-Jun Jiang, Bo Cui, Jiang-Bin Chen, Yang-Gan Wang, Hai-Rong Wang, Qin Yu, Jing He, Yi-Lin Mao, Xiao-Fang Bin, Yue Deng, Yu-Dan Tian, Qing-Hua Han, Da-Jin Liu, Li-Qin Duan, Ming-Jun Zhao, Cui-Ying Zhang, Hai-Ying Dai, Ze-Hua Li, Ying Xiao, You-Zhi Hu, Xiao-Yu Huang, Kun Xing, Xin Jiang, Chao-Feng Liu, Jing An, Feng-Chun Li, Tao Tao, Jin-Fa Jiang, Ying Yang, Yao-Rong Dong, Lei Zhang, Guang Fu, Ying Li, Shu-Wei Huang, Li-Ping Dou, Lan-Jun Sun, Ying-Qiang Zhao, Jie Li, Yun Xia, Fan Liu, Wen-Jin He, Jian-Cong Tan, Yang Lin, Ya-Bin Zhou, Jian-Fei Yang, Guo-Qing Ma, Hui-Jun Chen, He-Ping Liu, Zong-Wu Liu, Jian-Xiong Liu, Xiao-Jia Luo, Xiao-Hong Bin, Ya-Nan Yu, Hai-Xia Dang, Bing Li, Fei Teng, Wang-Min Qiao, Xiao-Long Zhu, Bing-Wei Chen, Qi-Guang Chen, Chun-Ti Shen, Yong-Yan Wang, Yun-Dai Chen, Zhong Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-10 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart disease. Here, in an adaptive, 31-cente
Autor:
Anna Christina Strobl, Tim H. H. Coorens, Adrienne M. Flanagan, Solange De Noon, Sam Behjati, Iben Lyskjaer, Jannat Ijaz, Fernanda Amary, Hongtao Ye
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 7, Iss 5, Pp 425-431 (2021)
Lyskjær, I 2021, ' MYC amplifications are common events in childhood osteosarcoma ', The journal of pathology. Clinical research . https://doi.org/10.1002/cjp2.219
De Noon, S, Ijaz, J, Coorens, T H H, Amary, F, Ye, H, Strobl, A, Lyskjær, I, Flanagan, A M & Behjati, S 2021, ' MYC amplifications are common events in childhood osteosarcoma ', Journal of Pathology: Clinical Research . https://doi.org/10.1002/cjp2.219
The Journal of Pathology: Clinical Research
Lyskjær, I 2021, ' MYC amplifications are common events in childhood osteosarcoma ', The journal of pathology. Clinical research . https://doi.org/10.1002/cjp2.219
De Noon, S, Ijaz, J, Coorens, T H H, Amary, F, Ye, H, Strobl, A, Lyskjær, I, Flanagan, A M & Behjati, S 2021, ' MYC amplifications are common events in childhood osteosarcoma ', Journal of Pathology: Clinical Research . https://doi.org/10.1002/cjp2.219
The Journal of Pathology: Clinical Research
Osteosarcoma, the most common primary malignant tumour of bone, affects both children and adults. No fundamental biological differences between paediatric and adult osteosarcoma are known. Here, we apply multi‐region whole‐genome sequencing to an
Autor:
Dejana Braithwaite, Jian-Guo Bian, Yi Guo, Elizabeth Shenkman, Sarah M Szurek, Jonathan D. Licht
Publikováno v:
Cancer Medicine, Vol 10, Iss 17, Pp 6048-6057 (2021)
Cancer Medicine
Cancer Medicine
Background People's fatalistic beliefs about cancer can influence their cancer prevention behaviors. We examined the association between fatalistic beliefs and breast and colorectal cancer screening among residents of north‐central Florida and test