Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Katsuhito Nagai"'
Autor:
Shuhei Fukuno, Katsuhito Nagai, Shizuka Yamaoka, Fuka Yamada, Haruna Mizumoto, Takuya Ito, Hiroki Konishi
Publikováno v:
The Journal of pharmacy and pharmacology. 74(2)
Objectives We investigated the pharmacokinetic interaction of doxorubicin (DOX) with phenytoin (PHT) and the underlying mechanism in rats to clarify why the serum PHT concentration decreases despite the impaired PHT metabolic capacity in patients rec
Publikováno v:
Xenobiotica. 49:1470-1477
1. 5-Fluorouracil (5-FU) is a pyrimidine derivative widely used for the treatment of cancer. In this study, we investigated the effects of 5-FU on the protein expression of hepatic CYP3A and their enzyme activity for metabolizing midazolam (MDZ), a t
Publikováno v:
Biopharmaceutics & Drug Disposition. 39:321-327
As there are to be known gender differences in the expression profiles of rat hepatic CYP2C, we examined the pharmacokinetic behavior of tolbutamide (TB), a typical probe for CYP2C, and hepatic enzyme activities for metabolizing TB in female rats to
Autor:
Natsumi Yoshida, Ayumi Yamamura, Keita Kasahara, Maho Kiyama, Katsuhito Nagai, Hiroki Konishi
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 45(10)
1. We examined the effects of doxorubicin (DOX) on the expression level and metabolic activity of CYP3A in the liver as well as on the pharmacokinetics of midazolam (MDZ), a probe for CYP3A, in rats. Changes in the hepatic status of DOX-treated rats
Publikováno v:
Biopharmaceuticsdrug disposition. 36(3)
Menthol is used widely as a constituent of functional foods and chemical drugs. The present study investigated changes in the pharmacokinetic behavior of intravenously administered midazolam (MDZ), a probe for CYP3A, when rats were treated with menth