Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gary J. Schwartz"'
Autor:
Huidong Shi, Gary J. Schwartz, Fenfen Li, Bingzhong Xue, Shirong Wang, Rui Wu, Liqing Yu, Jia Jing, Xin Cui, Qiang Cao, Ke Li, Hang Shi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Activation of brown fat thermogenesis increases energy expenditure and alleviates obesity. Sympathetic nervous system (SNS) is important in brown/beige adipocyte thermogenesis. Here we discover a fat-derived “adipokine” neurotrophic factor neurot
Inhibiting the prostaglandin transporter PGT induces non-canonical thermogenesis at thermoneutrality
Autor:
Rajat Singh, Marina Garcia Macia, Victor J. Pai, Run Lu, Licheng Wu, Yuling Chi, Wade Koba, Gary J. Schwartz, Victor L. Schuster
/ SUMMARYProstaglandins play fundamental roles in adipose tissue function. While prostaglandin F2α inhibits adipogenesis, prostaglandin E2 promotes adipose beiging. PGF2α and PGE2 are both inactivated through uptake by the plasma membrane transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13bea2c6127d9952593cc08ae735fc0
https://doi.org/10.1101/836288
https://doi.org/10.1101/836288
Autor:
Hale Ergin Egritag, Luiz Felipe Barella, Zhenzhong Cui, Sai Prasad Pydi, Douglas J. Oberlin, Oksana Gavrilova, Gary J. Schwartz, Christoph Buettner, Kevin W. Williams, Nikhil M. Urs, Jonathan Pham, Jürgen Wess, Zhenyan He, Yinghong Cui
Publikováno v:
Science Advances
This study suggests that agents able to enhance the activity of β-arrestin-1 in AgRP neurons may be useful as antidiabetic drugs.
β-Arrestin-1 and β-arrestin-2 have emerged as important signaling molecules that modulate glucose fluxes in seve
β-Arrestin-1 and β-arrestin-2 have emerged as important signaling molecules that modulate glucose fluxes in seve
Autor:
Paola Merlo, Rajat Singh, Marina García-Macia, Emily Liebling, Nuria Martinez-Lopez, Francesco Cecconi, Gary J. Schwartz, Srabani Sahu, Diana Athonvarangkul
Publikováno v:
Cell Metabolism. 23(1):113-127
The integrative physiology of inter-organ communication in lipophagy regulation is not well understood. Lipophagy and the cytosolic lipases ATGL and HSL contribute to lipid droplet (LD) mobilization; however, whether autophagy proteins engage with li
Autor:
Streamson C. Chua, Tamana Darwish, Keith Burling, Toni Vidal-Puig, Joanna Morro, Luke K. Burke, Sam Virtue, Clemence Blouet, Gary J. Schwartz, Althea R. Cavanaugh, Jing Xia, Shun Mei Liu, Emma Roth, Jeffrey W. Dalley
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the bra
Autor:
Rajat Singh, Marina García-Macia, Ana Batista-Gonzalez, Nuria Martinez-Lopez, Srabani Sahu, Jeffrey E. Pessin, Luisa Coletto, Sander Kersten, Elena Tarabra, Gary J. Schwartz, Míriam Toledo, Nir Barzilai
Publikováno v:
Cell Metabolism, 26(6), 856-871.e5
Cell Metabolism 26 (2017) 6
Cell Metabolism 26 (2017) 6
Autophagy failure is associated with metabolic insufficiency. Although caloric restriction (CR) extends healthspan, its adherence in humans is poor. We established an isocaloric twice-a-day (ITAD) feeding model wherein ITAD-fed mice consume the same
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f42e639ea96e6a5b7995aa2aca7395e
https://research.wur.nl/en/publications/system-wide-benefits-of-intermeal-fasting-by-autophagy
https://research.wur.nl/en/publications/system-wide-benefits-of-intermeal-fasting-by-autophagy
Autor:
Rajat Singh, Srabani Sahu, Claire C. Bastie, Nuria Martinez-Lopez, Diana Athonvarangkul, Jeffrey E. Pessin, Gary J. Schwartz, Luisa Coletto, Haihong Zong
Publikováno v:
EMBO Reports
Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development Atg7 deletion in Myf5+ progenitors blocks autophagy in brown adipose tissue and muscle, affecting their differentiati
Publikováno v:
Journal of Neuroscience. 32:9870-9877
Thioredoxin interacting protein (TXNIP) has recently been described as a key regulator of energy metabolism through pleiotropic actions that include nutrient sensing in the mediobasal hypothalamus (MBH). However, the role of TXNIP in neurochemically
Autor:
Zuha Jeddy, Hui Sun, Archana Vijayakumar, Xiaosong Li, Yingjie Wu, Shoshana Yakar, Chengyu Liu, Derek LeRoith, Gary J. Schwartz
Publikováno v:
Diabetes
Growth hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed by global alteration of GH action. To study the direct metabolic effects of GH in the muscle, we specifically inactivated the growth hormone receptor (ghr) gen
Publikováno v:
Endocrinology. 152:883-889
Neuropeptide Y (NPY) and agouti-related peptide (AGRP) can produce hyperphagia, reduce energy expenditure, and promote triglyceride deposition in adipose depots. As these two neuropeptides are coexpressed within the hypothalamic arcuate nucleus and m