Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John D. Hildebrandt"'
Publikováno v:
Journal of Biological Chemistry. 279:36601-36607
A Ser to Asn mutation at position 54 of the alpha subunit of G(s) (designated N54-alpha(s)) was characterized after transient expression of it with various components of the receptor-adenylyl cyclase pathway in COS-1, COS-7, and HEK 293 cells. Previo
Autor:
Joseph P. Pieroni, Gezhi Weng, Jinrong Li, Harel Weinstein, John D. Hildebrandt, Frank Guarnieri, Yibang Chen, Jane Dingus, Ravi Iyengar, Anya Harry
Publikováno v:
Proceedings of the National Academy of Sciences. 94:2711-2714
Receptor activation of heterotrimeric G proteins dissociates G alpha from the G betagamma complex, allowing both to regulate effectors. Little is known about the effector-interaction regions of G betagamma. We had used molecular modeling to dock a pe
Publikováno v:
Journal of Biological Chemistry. 271:26445-26448
The region encoded by amino acids 956-982 of adenylyl cyclase 2 is important for Gβγ stimulation. Interactions of a peptide encoding the 956-982 region of adenylyl cyclase 2 (QEHAQEPERQYMHIGTMVEFAYALVGK (QEHA peptide)) with Gβγ subunits were stud
Publikováno v:
Journal of Biological Chemistry. 277:50223-50225
A ligand-independent activator of heterotrimeric brain G-protein was partially purified from detergent-solubilized extracts of the neuroblastoma-glioma cell hybrid NG108-15. The G-protein activator (NG108-15 G-protein activator (NG-GPA)) increased [(
Autor:
Jianqiang Chen, John H. Exton, Robert H. Stoffel, John D. Hildebrandt, James Inglese, Michael DeVivo, Jingrong Li, Anya Harry, Robert J. Lefkowitz, Jonathan L. Blank, Ravi lyengar, Jane Dingus, Diomedes E. Logothetis, Donna J. Carty, Jin-Liang Sui
Publikováno v:
Science (New York, N.Y.). 268(5214)
Receptor-mediated activation of heterotrimeric guanine nucleotide-binding proteins (G proteins) results in the dissociation of alpha from beta gamma subunits, thereby allowing both to regulate effectors. Little is known about the regions of effectors
Autor:
Juan Codina, Ravi Iyengar, John D. Hildebrandt, Lutz Birnbaumer, Arthur M. Brown, Atsuko Yatani
Publikováno v:
Protein Design and the Development of New Therapeutics and Vaccines ISBN: 9781468457414
About 80% of all hormone and neurotransmitter receptors interact with signal transducing GTP-binding proteins (G proteins) to modulate cell activity. G proteins are αβγ heterotrimers, and although not unequivocally proven, there is general agreeme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f75108ead233a85870e53f6abc1eb51
https://doi.org/10.1007/978-1-4684-5739-1_8
https://doi.org/10.1007/978-1-4684-5739-1_8
Identification of a gamma subunit associated with the adenylyl cyclase regulatory proteins Ns and Ni
Publikováno v:
Journal of Biological Chemistry. 259:2039-2042
The subunit composition of the Ns and Ni, the human erythrocyte stimulatory and inhibitory regulatory proteins of adenylyl cyclase, respectively, were analyzed by a sodium dodecyl sulfate-containing discontinuous urea and polyacrylamide gradient gel
Publikováno v:
Journal of Biological Chemistry. 259:11408-11418
The effect of GTP analogs and Mg on the structure of Ns and Ni, the stimulatory and inhibitory regulatory components of adenylyl cyclase, were studied in a comparative manner. Both N proteins, which are alpha beta gamma heterotrimers that differ in t
Autor:
Walter Rosenthal, Juan Codina, E J Neer, John D. Hildebrandt, A Yamazaki, M W Bitensky, Lutz Birnbaumer
Publikováno v:
Journal of Biological Chemistry. 260:14867-14872
Ns and Ni, the regulatory proteins affecting adenylyl cyclase, and transducin, the guanine nucleotide-binding protein from rod outer segments of the eye, are structurally and functionally related proteins. Of these, the alpha subunits are between 39
Publikováno v:
Journal of Biological Chemistry. 259:7893-7901
Treatment of MDCK cells with glucagon results in decreases in glucagon, NaF and prostaglandin E1-stimulated adenylyl cyclase activities, indicating the occurrence of a heterologous desensitization process. The extent of desensitization was time and g