Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Joe S. Mymryk"'
Autor:
Gregory J. Fonseca, Katelyn M. MacNeil, Mackenzie J. Dodge, Jessie Tu, Peter Pelka, Martin Prusinkiewicz, Joe S. Mymryk, Sandi Radko-Juettner
Publikováno v:
Viruses
Volume 12
Issue 6
Viruses, Vol 12, Iss 610, p 610 (2020)
Volume 12
Issue 6
Viruses, Vol 12, Iss 610, p 610 (2020)
Viruses alter a multitude of host-cell processes to create a more optimal environment for viral replication. This includes altering metabolism to provide adequate substrates and energy required for replication. Typically, viral infections induce a me
Publikováno v:
J Virol
Human adenoviruses (HAdV) are ubiquitous within the human population and comprise a significant burden of respiratory illnesses worldwide. Pediatric and immunocompromised individuals are at particular risk for developing severe disease; however, no a
Publikováno v:
Antiviral Res
Human adenoviruses (HAdV) are ubiquitous human pathogens that cause a significant burden of respiratory, ocular, and gastrointestinal illnesses. Although HAdV infections are generally self-limiting, pediatric and immunocompromised individuals are at
Autor:
Lisa Y. Zhao, Scott M. Dehm, Frank Claessens, Joe S. Mymryk, Daiqing Liao, Olivia Co, Jia Wang, Guimei Tian, Zoe C. Underill, Dawei Li, Yehia Daaka
Publikováno v:
The Prostate. 78(15)
BACKGROUND: Mutations or truncation of the ligand-binding domain (LBD) of androgen receptor (AR) underlie treatment resistance for prostate cancer (PCa). Thus, targeting the AR N-terminal domain (NTD) could overcome such resistance. METHODS: Lucifera
Publikováno v:
Journal of Virology. 88:13469-13481
The adenovirus E1A gene is the first gene expressed upon viral infection. E1A remodels the cellular environment to maximize permissivity for viral replication. E1A is also the major transactivator of viral early gene expression and a coregulator of a
Publikováno v:
Journal of Virology. 88:5630-5637
During infection by human adenovirus (HAdV), the proteins encoded by the early region 1A (E1A) gene bind and appropriate components of the cellular transcriptional machinery to activate the transcription of viral early genes. Previously, we identifie
Autor:
Joe S. Mymryk, Cason R. King, Ahmed F. Yousef, Kris S. Marshall, Greg J. Fonseca, Biljana Todorovic, Zhiying Zhang, Michael J. Cohen
Publikováno v:
Virology. :206-214
The human adenovirus 5 (HAdV-5) E1A protein has a well defined canonical nuclear localization signal (NLS) located at its C-terminus. We used a genetic assay in the yeast Saccharomyces cerevisiae to demonstrate that the canonical NLS is present and f
Autor:
Martin Prusinkiewicz, Joe S. Mymryk
Publikováno v:
Viruses, Vol 11, Iss 2, p 141 (2019)
Viruses
Viruses
Viruses are obligate intracellular parasites that alter many cellular processes to create an environment optimal for viral replication. Reprogramming of cellular metabolism is an important, yet underappreciated feature of many viral infections, as th
Publikováno v:
Nature
Viral proteins mimic host protein structure and function to redirect cellular processes and subvert innate defenses1. Small basic proteins compact and regulate both viral and cellular DNA genomes. Nucleosomes are the repeating units of cellular chrom
Autor:
Jailal N. G. Ablack, Gobi Thillainadesan, Michael J. Cohen, Gregory J. Fonseca, Joe S. Mymryk, Peter Pelka, Joseph Torchia
Publikováno v:
Journal of Virology. 86:8198-8209
The largest isoform of adenovirus early region 1A (E1A) contains a unique region termed conserved region 3 (CR3). This region activates viral gene expression by recruiting cellular transcription machinery to the early viral promoters. Recent studies