Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Pedro R. Lowenstein"'
Publikováno v:
Molecular Cancer Therapeutics. 13:3024-3036
The success of immunotherapeutic approaches targeting glioblastoma multiforme (GBM) demands a robust antiglioma T-cell cytotoxic and memory response. Recent evidence suggests that rapamycin regulates T-cell differentiation. Herein, we tested whether
Autor:
Liliana M. Lacayo, Johnny Krasinkiewicz, Catherine Farrokhi, Mariana Puntel, Maria G. Castro, Kyle R. Kelson, Ghulam Muhammad A.K.M., Sukhpreet Kaur, Nathan VanderVeen, Philip Ng, Sean Kennedy, Robert N. Pechnick, Christopher Paran, Pedro R. Lowenstein, Ashley Appelhans, Kurt M. Kroeger, Alireza Salem, Donna Palmer, Chunyan Liu
Publikováno v:
Toxicology and Applied Pharmacology. 268:318-330
Adenoviral vectors (Ads) are promising gene delivery vehicles due to their high transduction efficiency; however, their clinical usefulness has been hampered by their immunogenicity and the presence of anti-Ad immunity in humans. We reported the effi
Autor:
Kyle R. Kelson, Philip Ng, Robert N. Pechnick, Pedro R. Lowenstein, Kurt M. Kroeger, Weidong Xiong, Alireza Salem, A.K.M. Ghulam Muhammad, Chunyan Liu, Donna Palmer, Liliana M. Lacayo, Mariana Puntel, Maria G. Castro, Catherine Farrokhi
Publikováno v:
Human Gene Therapy Methods. 23:271-284
Adenoviral vectors (Ads) have been evaluated in clinical trials for glioma. However, systemic immunity against the vectors can hamper therapeutic efficacy. We demonstrated that combined immunostimulation and cytotoxic gene therapy provides long-term
Autor:
Daniel Zamler, Maria G. Castro, Pedro R. Lowenstein, Philip Ng, Nicholas Raja, Henry D. Appelman, Elizabeth Yi, Marta Dzaman, Donna Palmer, Nathan VanderVeen
Publikováno v:
Human gene therapy methods. 27(3)
Glioblastoma multiforme (GBM) is the most commonly occurring primary brain cancer in adults, in whom its highly infiltrative cells prevent total surgical resection, often leading to tumor recurrence and patient death. Our group has discovered a gene
Autor:
Mark Swerdlow, Maria G. Castro, Niyati Bondale, Kurt M. Kroeger, Nicholas R. Sanderson, Mariana Puntel, Niloufar Iranmanesh, Hideo Yagita, Ahmed Ibrahim, Pedro R. Lowenstein
Publikováno v:
Proceedings of the National Academy of Sciences. 109:7835-7840
Following antigen recognition on target cells, effector T cells establish immunological synapses and secrete cytokines. It is thought that T cells secrete cytokines in one of two modes: either synaptically (i.e., toward antigenic target cells) or mul
Autor:
Rameen S. Moridzadeh, Jeffrey M. Zirger, Chunyan Liu, Josee Bergeron, Pedro R. Lowenstein, Mariana Puntel, Carlos Barcia, Maria G. Castro, Mia Wibowo, Kurt M. Kroeger, Niyati Bondale
Publikováno v:
Molecular Therapy
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The adaptive immune response to viral vectors reduces vector-mediated transgene expression from the brain. It is unknown, however, whether this loss is caused by functional downregulation of transgene expression or death of transduced cells. Herein,
Autor:
Kurt M. Kroeger, Maria G. Castro, Gwendalyn D. King, Pedro R. Lowenstein, Akm Ghulam Muhammad, Serguei Bannykh, Yohei Mineharu, Chunyan Liu
Publikováno v:
Clinical Cancer Research. 17:4705-4718
Purpose: Glioblastoma multiforme (GBM) is a deadly primary brain tumor. Clinical trials for GBM using dendritic cell (DC) vaccination resulted in antitumor immune responses. Herein, we tested the hypothesis that combining in situ (intratumoral) Ad-Fl
Autor:
John R. Ohlfest, Cathy S. Carlson, Patrick T. Grogan, Pedro R. Lowenstein, Wei Chen, Michelle R. Goulart, Maria G. Castro, Michael R. Olin, Karen S. SantaCruz, G. Elizabeth Pluhar, Charlie Seiler, Stephen J. Haines
Publikováno v:
Vaccine. 28:3371-3378
Gene therapy and vaccination have been tested in malignant glioma patients with modest, albeit encouraging results. The combination of these therapies has demonstrated synergistic efficacy in murine models but has not been reported in large animals.
Autor:
A. Salem, Kurt M. Kroeger, Sonali Mondkar, Niyati Bondale, Yang Shi, A. K. M. Muhammad, V. Saxena, P. Ng, Chunyan Liu, A. Zadmehr, P. Huynh, Pedro R. Lowenstein, Robert Barrett, Mariana Puntel, Donna Palmer, Sandra A. Sciascia, Weidong Xiong, Maria G. Castro
Publikováno v:
Journal of Virology. 83:2004-2010
Increased transgene expression per vector genome is an important goal in the optimization of viral vectors for gene therapy. Herein we demonstrate that herpes simplex virus type 1 (HSV1) thymidine kinase (TK) gene sequences (1,131 bp) fused to the 3
Autor:
Javier Martin, Emiliano Fernández-Villalba, Chunyan Liu, Maria G. Castro, Pedro R. Lowenstein, Kurt M. Kroeger, Vicente de Pablos, A. Gómez, Carlos Barcia, Maria Herrero, Andrés Fernández Barreiro
Publikováno v:
Journal of Virology. 82:9978-9993
The clearance of virally infected cells from the brain is mediated by T cells that engage antigen-presenting cells to form supramolecular activation clusters at the immunological synapse. However, after clearance, the T cells persist at the infection