Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Pedro R. Lowenstein"'
Autor:
Kyle R. Kelson, Philip Ng, Robert N. Pechnick, Pedro R. Lowenstein, Kurt M. Kroeger, Weidong Xiong, Alireza Salem, A.K.M. Ghulam Muhammad, Chunyan Liu, Donna Palmer, Liliana M. Lacayo, Mariana Puntel, Maria G. Castro, Catherine Farrokhi
Publikováno v:
Human Gene Therapy Methods. 23:271-284
Adenoviral vectors (Ads) have been evaluated in clinical trials for glioma. However, systemic immunity against the vectors can hamper therapeutic efficacy. We demonstrated that combined immunostimulation and cytotoxic gene therapy provides long-term
Autor:
A. Salem, Kurt M. Kroeger, Sonali Mondkar, Niyati Bondale, Yang Shi, A. K. M. Muhammad, V. Saxena, P. Ng, Chunyan Liu, A. Zadmehr, P. Huynh, Pedro R. Lowenstein, Robert Barrett, Mariana Puntel, Donna Palmer, Sandra A. Sciascia, Weidong Xiong, Maria G. Castro
Publikováno v:
Journal of Virology. 83:2004-2010
Increased transgene expression per vector genome is an important goal in the optimization of viral vectors for gene therapy. Herein we demonstrate that herpes simplex virus type 1 (HSV1) thymidine kinase (TK) gene sequences (1,131 bp) fused to the 3
Autor:
Maria G. Castro, Philip Ng, Donna Palmer, Mariana Puntel, A.K.M. Ghulam Muhammad, Weidong Xiong, Pedro R. Lowenstein, Kurt M. Kroeger, Gwendalyn D. King, Daniel Larocque
Publikováno v:
Journal of Virology. 82:4680-4684
Gene therapy is proposed as a novel therapeutic strategy for treating glioblastoma multiforme (GBM), a devastating brain cancer. In the clinic, antivector immune responses pose formidable challenges. Herein we demonstrate that high-capacity adenoviru
Autor:
Charlene M. Manalo, Kurt M. Kroeger, Chunyan Liu, Maria G. Castro, Pedro R. Lowenstein, Catherine Bresee, Akm Ghulam Muhammad, Robert N. Pechnick, Gwendalyn D. King, Marianela Candolfi
Publikováno v:
Molecular Therapy. 16:682-690
Glioblastoma multiforme (GBM) is an invasive and aggressive primary brain tumor which is associated with a dismal prognosis. We have earlier developed a macroscopic, intracranial, syngeneic GBM model, in which treatment with adenoviral vectors (Ads)
Autor:
Andrew Freese, A.K.M. Ghulam Muhammad, Sonali Mondkar, Terry Kang, Kurt M. Kroeger, P. Ng, Peter F Moore, John D. Young, William Kuoy, G. Elizabeth Pluhar, Elizabeth A. McNeil, Pedro R. Lowenstein, Marianela Candolfi, Carlos Barcia, Donna Palmer, Maria G. Castro, Weidong Xiong, John R. Ohlfest, Chunyan Liu, Mariana Puntel, James F. Curtin
Publikováno v:
Neuro-Oncology. 9:245-258
Expression of the immune-stimulatory molecule Fms-like tyrosine kinase 3 ligand (Flt3L) and the conditional cytotoxic enzyme herpes simplex virus type 1 thymidine kinase (HSV1-TK) provides long-term immune-mediated survival of large glioblastoma mult
Autor:
Christine M. Cowsill, G. Morrissey, Daniel Stone, Adam J. Zermansky, Pedro R. Lowenstein, Federico Bolognani, Maria G. Castro
Publikováno v:
Molecular Therapy. 4(5):490-498
One of the challenges of neurological gene therapy for the treatment of chronic neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases, is achieving high levels, widespread distribution, and long-lived transgene expression in the b
Publikováno v:
Trends in Endocrinology & Metabolism. 12:58-64
The main objectives of pituitary tumour treatment are to restore normal function of the pituitary gland and prevent tumour recurrences. In spite of the success of current therapies in the treatment of relatively small tumours, new therapeutic alterna
Publikováno v:
Biochemical Society Transactions. 27:873-881
Autor:
Gavin William Grahame Wilkinson, A.F. Shering, Alberto L. Epstein, Maria G. Castro, Pedro R. Lowenstein, D. Bain, Kirsten Stewart
Publikováno v:
Journal of General Virology. 78:445-459
Expression from a short human cytomegalovirus (HCMV) major immediate early (IE) promoter-enhancer was tested in three different virus vectors: recombinant adenovirus (Ad), recombinant herpes simplex virus type 1 (HSV-1) and HSV-1-derived amplicon vec
Autor:
Chunyan Liu, Robert Barrett, Maria G. Castro, Mariana Puntel, Kurt M. Kroeger, Niyati Bondale, Pedro R. Lowenstein, Mia Wibowo, Nicholas S. R. Sanderson, Sean F. Kennedy
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23523 (2011)
PLoS ONE
PLoS ONE
CD8(+) T cells infiltrate the brain during an anti-viral immune response. Within the brain CD8(+) T cells recognize cells expressing target antigens, become activated, and secrete IFNγ. However, there are no methods to recognize individual cells tha