Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pedro R. Lowenstein"'
Publikováno v:
Current Gene Therapy. 7:347-360
Researchers have conducted numerous pre-clinical and clinical gene transfer studies using recombinant viral vectors derived from a wide range of pathogenic viruses such as adenovirus, adeno-associated virus, and lentivirus. As viral vectors are deriv
Autor:
Elizabeth A. McNeil, Kurt M. Kroeger, Maria G. Castro, Andrew Freese, John R. Ohlfest, G. Elizabeth Pluhar, Pedro R. Lowenstein, Chunyan Liu, Seung Uk Oh
Publikováno v:
Journal of Neurosurgery. 107:136-144
Object The purpose of this study was to evaluate the gene transfer capability and tolerability of plasmid DNA/poly-ethylenimine (PEI) complexes in comparison with adenovirus and naked plasmid DNA in the canine brain. Methods Plasmid or adenoviral vec
Autor:
Josee Bergeron, James F. Curtin, Elizabeth A. McNiel, John R. Ohlfest, Peter F Moore, Maria G. Castro, Mariana Puntel, Kurt M. Kroeger, Andrew Freese, Pedro R. Lowenstein, G. Elizabeth Pluhar, Marianela Candolfi
Publikováno v:
Neurosurgery. 60:167-178
Glioblastoma multiforme (GBM), the most common type of primary brain tumor in adults, is an aggressive and locally invasive tumor. Survival of patients affected by GBM has remained virtually unchanged during the past decades (6−12 mo after diagnosi
Autor:
Judith C. Williams, Pedro R. Lowenstein, Ian D. Morris, Joseph R. Smith-Arica, Maria G. Castro, Daniel Stone
Publikováno v:
Molecular Therapy. 4:593-602
Prolactin-secreting adenomas are one of the most common types of intracranial neoplasm found in humans. The modalities of clinical treatment currently in use include D(2)-dopamine receptor agonists, surgery, and radiotherapy, and the success rates fo
Autor:
Hélène Coathalem, Nico van Rooijen, Laurent Tesson, Maria-Cristina Cuturi, Jean-Paul Soulillou, Emmanuelle Gilbert, J Chetritt, A. David, Cécile Guillot, Pedro R. Lowenstein, Ignacio Anegon
Publikováno v:
The Journal of Immunology. 166:5225-5235
The putative role of IL-4 in human and animal models of hepatitis has not yet been directly determined. We now report that direct expression of IL-4 in the liver of rats or mice using recombinant adenoviruses coding for rat or mouse IL-4 (AdrIL-4 and
Publikováno v:
Molecular Therapy. 2(4):330-338
Using the major immediate early murine cytomegalovirus (MIEmCMV) promoter to drive expression of beta-galactosidase, we have demonstrated that, following adenoviral-mediated transduction of brain cells in vivo, a single viral infectious unit is capab
Autor:
Maria-Cristina Cuturi, Jean-Paul Soulillou, Sophie Brouard, Pedro R. Lowenstein, Laurent Tesson, Claire Usal, Ignacio Anegon, Hélène Coathalem, Maria G. Castro, Brigitte Le Mauff, Patrick Mathieu, Cécile Guillot, Thomas Laumonier
Publikováno v:
Journal of Immunology, Vol. 164, No 10 (2000) pp. 5258-68
Blockade of the CD28/B7 T cell costimulatory pathway prolongs allograft survival and induces tolerance in some animal models. We analyzed the efficacy of a CTLA4Ig-expressing adenovirus in preventing cardiac allorejection in rats, the mechanisms unde
Publikováno v:
Endocrine-related cancer. :475-481
Autor:
Yolanda E. Sosa, Pedro R. Lowenstein, Joanna Rowe, Rodolfo G. Goya, Adriana T. Larregina, Maria G. Castro, Adrian E. Morelli
Publikováno v:
Endocrinology. 138:2184-2194
Adenovirus vectors have recently been used to transfer genes into a variety of cell types, including neurons, glial cells, Schwann cells, and epithelial cells. To evaluate the efficiency of gene transfer into pituitary cells using viral vectors, we u
Autor:
Chunyan Liu, Sharon Lee, Kurt M. Kroeger, Ali Zadmehr, Gabrielle E. Ahlzadeh, Marianela Candolfi, Ronald Rodriguez, Clive N. Svendsen, Waldemar Debinski, Kader Yagiz, Mariana Puntel, Pedro R. Lowenstein, Akm Ghulam Muhammad, Maria G. Castro, David Foulad, Dhruv Sareen, Matthew Tesarfreund, Weidong Xiong
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(46)
Restricting the cytotoxicity of anticancer agents by targeting receptors exclusively expressed on tumor cells is critical when treating infiltrative brain tumors such as glioblastoma multiforme (GBM). GBMs express an IL-13 receptor (IL13Rα2) that di