Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Friedrich Koch-Nolte"'
Autor:
Waldemar Schäfer, Tobias Stähler, Carolina Pinto Espinoza, Welbeck Danquah, Jan Hendrik Knop, Björn Rissiek, Friedrich Haag, Friedrich Koch-Nolte
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
P2X7, an ion channel gated by extracellular ATP, is widely expressed on the plasma membrane of immune cells and plays important roles in inflammation and apoptosis. Several single nucleotide polymorphisms have been identified in the human P2RX7 gene.
Externí odkaz:
https://doaj.org/article/26f84250e7004adb9dcfa2953cc3b8fb
Autor:
Mélanie Demeules, Allan Scarpitta, Romain Hardet, Henri Gondé, Catalina Abad, Marine Blandin, Stephan Menzel, Yinghui Duan, Björn Rissiek, Tim Magnus, Anna Marei Mann, Friedrich Koch-Nolte, Sahil Adriouch
Publikováno v:
Frontiers in Immunology. 13
Adenosine triphosphate (ATP) represents a danger signal that accumulates in injured tissues, in inflammatory sites, and in the tumor microenvironment. ATP promotes tumor growth but also anti-tumor immune responses notably via the P2X7 receptor. ATP c
Autor:
Maximilian Wilmes, Carolina Pinto Espinoza, Peter Ludewig, Joschi Stabernack, Arthur Liesz, Annette Nicke, Mathias Gelderblom, Christian Gerloff, Simonetta Falzoni, Eva Tolosa, Francesco Di Virgilio, Björn Rissiek, Nikolaus Plesnilla, Friedrich Koch-Nolte, Tim Magnus
Publikováno v:
Journal of Neuroinflammation. 19
Background Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple models of brain diseases. However, tools for the selective and efficient targeting of these recepto
Autor:
Riekje Winzer, Arnau Serracant‐Prat, Valerie J. Brock, Carolina Pinto‐Espinoza, Björn Rissiek, Miriam Amadi, Niklas Eich, Anne Rissiek, Enja Schneider, Tim Magnus, Andreas H. Guse, Björn‐Philipp Diercks, Friedrich Koch‐Nolte, Eva Tolosa
Publikováno v:
European journal of immunologyReferences. 52(11)
Extracellular ATP activates the P2X7 receptor, leading to inflammasome activation and release of pro-inflammatory cytokines in monocytes. However, a detailed analysis of P2X7 receptor expression and function in the human T cell compartment has not be
Autor:
Tobias, Stähler, Welbeck, Danquah, Melanie, Demeules, Henri, Gondé, Romain, Hardet, Friedrich, Haag, Sahil, Adriouch, Friedrich, Koch-Nolte, Stephan, Menzel
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2510
Antibodies that recognize the ATP-gated P2X7 ion channel are etablished research tools. Nanobodies correspond to the antigen-binding variable immunoglobulin domain (VHH) of heavy chain antibodies that naturally occur in camelids. Nanobodies display b
Autor:
Parimah, Ahmadi, Ming, Yan, Andreas, Bauche, Ralf, Smeets, Christa E, Müller, Friedrich, Koch-Nolte, Friedrich, Haag, Ralf, Fliegert, Lan, Kluwe, Julian, Schulze Zur Wiesch, Philip, Hartjen
Publikováno v:
Cellular immunology. 380
The pulp of human teeth contains a population of self-renewing stem cells that can regulate the functions of immune cells. When applied to patients, these cells can protect tissues from damage by excessive inflammation. We confirm that dental pulp ce
Autor:
Andreas H. Guse, Christian Lohr, Chris Meier, Ralf Fliegert, Friedrich Koch-Nolte, Viacheslav O. Nikolaev, Jörg Heeren
Publikováno v:
Biochemical Society Transactions. 47:329-337
Adenine nucleotides (AdNs) play important roles in immunity and inflammation. Extracellular AdNs, such as adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD) and their metabolites, act as paracrine messengers by fine-tuning both p
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2041
Mammalian purinoreceptors respond to extracellular nucleotides and their metabolites, for example, following the release of ATP or NAD
Autor:
Nicole Schwarz, Friedrich Koch-Nolte, Carolina Pinto-Espinoza, Henri Gondé, Mélanie Demeules, Anna Marei Eichhoff, Tobias Schäfer, Sahil Adriouch, Friedrich Haag, Stephan Menzel
Publikováno v:
Current opinion in pharmacology. 47
Targeting the P2X7 ion channel, a danger sensor for extracellular nucleotides, improves outcomes in models of inflammation, cancer, and brain-diseases. Antibodies and nanobodies have been developed that antagonize or potentiate gating of P2X7. Their
Autor:
Sorush Nader, Friedrich Haag, Insa M. A. Wolf, Andreas H. Guse, Viacheslav O. Nikolaev, Enja Schneider, Bjarne Johnsen, Klaus Eric Kaschubowski, Friedrich Koch-Nolte, Ralf Fliegert, Jan-Andrei Nicola
Publikováno v:
Purinergic Signalling
ATP and its metabolites are important extracellular signal transmitters acting on purinergic P2 and P1 receptors. Most cells can actively secrete ATP in response to a variety of external stimuli such as gating of the P2X7 receptor. We used Yac-1 muri