Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sven Perner"'
Autor:
Iris Watermann, Christiane Kuempers, Till Olchers, Jutta Kirfel, Christian Kugler, Mark Kuehnel, Martin Reck, Danny Jonigk, Mario C. Deng, Torsten Goldmann, Ole Ammerpohl, Helen Pasternack, Sven Perner, Florian Stellmacher
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
The only potentially curative treatment for lung adenocarcinoma patients remains complete resection of early-stage tumors. However, many patients develop recurrence and die of their disease despite curative surgery. Underlying mechanisms leading to e
Autor:
Christiane Kuempers, Christian Kugler, David Benjamin Ellebrecht, Sven Perner, Markus Kleemann
Publikováno v:
Biomedical Engineering / Biomedizinische Technik. 66:285-292
Cancer will be the leading cause of death in a few decades. In line with minimal invasive lung cancer surgery, surgeons loose most of their tactile tissue information and need an additional tool of intraoperative tissue navigation during surgery. Con
Autor:
Sebastian Marwitz, Anne Offermann, Anke Fähnrich, Mark P. Kühnel, Sven Perner, Mladen Jokic, Christiane Kümpers, Carsten Heidel, Helen Pasternack, Sabine Bohnet, Ignacija Vlasic, Jutta Kirfel, Hauke Busch, Torsten Goldmann, Danny Jonigk
Publikováno v:
Cancers
Volume 13
Issue 18
Cancers, Vol 13, Iss 4562, p 4562 (2021)
Volume 13
Issue 18
Cancers, Vol 13, Iss 4562, p 4562 (2021)
Background: Lung cancer is the most frequent cause of cancer-related deaths worldwide. The clinical development of immune checkpoint blockade has dramatically changed the treatment paradigm for patients with lung cancer. Yet, an improved understandin
Autor:
Filippo Beleggia, Hendrik Nolte, Niklas Klümper, Vasiliki Liaki, Hans Christian Reinhardt, Lars Tharun, Alessandro Torgovnick, Florian Siedek, Sven Perner, Jörg Isensee, Jan Michel Heger, Lucie Laurien, Gero Knittel, Maike Wittersheim, Reinhard Büttner, Anna Schmitt, Manolis Pasparakis, Arina Riabinska, Uschi Leeser, Wenzel Vogel, Christian Jüngst, Roberta Castiglione, Thorsten Persigehl, Grit Herter-Sprie, Tim Hucho, Astrid Schauss, Björn Schumacher, Marcus Krüger
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1027-1039.e6 (2018)
Summary: Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to gen
Autor:
David Benjamin, Ellebrecht, Christiane, Kuempers, Sven, Perner, Christian, Kugler, Markus, Kleemann
Publikováno v:
Biomedizinische Technik. Biomedical engineeringReferences. 66(3)
Cancer will be the leading cause of death in a few decades. In line with minimal invasive lung cancer surgery, surgeons loose most of their tactile tissue information and need an additional tool of intraoperative tissue navigation during surgery. Con
Autor:
U. Leeser, Martin Peifer, Tsun-Po Yang, Reinhard Büttner, Sven Perner, Daniela Welcker, Michael Nowak, Anna Schmitt, Gero Knittel, Hans Christian Reinhardt, Julie George
Publikováno v:
Cancer Research. 77:3040-3056
Defects in maintaining genome integrity are a hallmark of cancer. The DNA damage response kinase ATM is frequently mutated in human cancer, but the significance of these events to chemotherapeutic efficacy has not been examined deeply in whole organi
Autor:
Arina Riabinska, Miriam Rinneburger, Wenzel Vogel, Alexandra Florin, Mehmet Akyüz, Björn Schumacher, Reinhard Büttner, Christian Fritz, Sebastian Michels, Christiane Kümpers, Jürgen Thomale, David Maintz, Sven Perner, Mladen Jokic, Anne Offermann, Luka Ozretić, Maike Wittersheim, Thorsten Persigehl, Niklas Klümper, Anna Schmitt, Judith Eva Spiro, Michael Nowak, Martin Erkel, Hans Christian Reinhardt, Ignacija Vlasic, Jürgen Wolf, Daniela Welcker
Publikováno v:
Molecular Cancer Research. 14:1110-1123
KRAS-mutant lung adenocarcinoma is among the most common cancer entities and, in advanced stages, typically displays poor prognosis due to acquired resistance against chemotherapy, which is still largely based on cisplatin-containing combination regi
Publikováno v:
World journal of urology. 38(3)
To systematically and comprehensively review and summarize the most recent literature assessing the value of the new grading system introduced by the International Society of Urological Pathology (ISUP) in 2014 and accepted by the World Health Organi
Autor:
Nils C. Lehnen, Sven Perner, Glen Kristiansen, Manuel H. Schäfer, Tobias Höller, Philipp Lingohr, Anke Sträßer, Ines Gütgemann, Jörg C. Kalff, Martin Braun
Publikováno v:
Human Pathology. 46:1488-1495
Gastric adenocarcinomas are associated with a poor prognosis due to the fact that the tumor has often metastasized by the time of diagnosis. Thus, identification of novel therapeutic targets is highly desirable. Here, we examined gene copy number of
Autor:
Lindsay Marek, Joseph M. Gozgit, D.R. Camidge, Jacek Jassem, Sven Perner, Dexiang Gao, Fred R. Hirsch, Trista K. Hinz, Diana Böhm, Paul A. Bunn, Wojtylak S, Ware Ke, Murry W. Wynes, Aleksandra Sejda, Aik Choon Tan, Lynn E. Heasley, Michael L Martini, Rafal Dziadziuszko, Barbara Helfrich, Michael G. Edwards
Publikováno v:
Clinical Cancer Research. 20:3299-3309
Purpose: FGFR1 gene copy number (GCN) is being evaluated as a biomarker for FGFR tyrosine kinase inhibitor (TKI) response in squamous cell lung cancers (SCC). The exclusive use of FGFR1 GCN for predicting FGFR TKI sensitivity assumes increased GCN is