Zobrazeno 1 - 10
of 49
pro vyhledávání: '"M. Solis"'
Autor:
Dapeng Hao, Guangchun Han, Ansam Sinjab, Lorena Isabel Gomez-Bolanos, Rossana Lazcano, Alejandra Serrano, Sharia D. Hernandez, Enyu Dai, Xuanye Cao, Jian Hu, Minghao Dang, Ruiping Wang, Yanshuo Chu, Xingzhi Song, Jianhua Zhang, Edwin R. Parra, Jennifer A. Wargo, Stephen G. Swisher, Tina Cascone, Boris Sepesi, Andrew P. Futreal, Mingyao Li, Steven M. Dubinett, Junya Fujimoto, Luisa M. Solis Soto, Ignacio I. Wistuba, Christopher S. Stevenson, Avrum Spira, Shabnam Shalapour, Humam Kadara, Linghua Wang
Publikováno v:
Cancer Discov
Tumor-infiltrating B and plasma cells (TIB) are prevalent in lung adenocarcinoma (LUAD); however, they are poorly characterized. We performed paired single-cell RNA and B-cell receptor (BCR) sequencing of 16 early-stage LUADs and 47 matching multireg
Autor:
Ichidai Tanaka, Gargy Parhy, Jaime Rodriguez-Canales, Veera Baladandayuthapani, Francesco C. Stingo, Toyofumi F. Chen-Yoshikawa, Rekha Jain, Seiichi Kato, Jennifer B. Dennison, Kim Anh Do, Yasushi Yatabe, Taisuke Kajino, Kohei Yokoi, Masahiro Nakatochi, Edwin R. Parra, Koji Kawaguchi, Mei Chee Tai, Clemente Aguilar-Bonavides, Ignacio I. Wistuba, Hiroyuki Katayama, Nese Unver, Muge Celiktas, Delphine Dayde, Barbara Mino, Waki Hosoda, Edwin J. Ostrin, Dilsher Dhillon, Johannes F. Fahrmann, Philip L. Lorenzi, Samir M. Hanash, Junya Fujimoto, Carmen Behrens, Yoshiko Murakami, Takayuki Fukui, Satyendra C. Tripathi, Tetsunari Hase, Yoshinori Hasegawa, Julian P. Casabar, Hong Wang, Adi F. Gazdar, Haruki Mori, Ayumu Taguchi, Luisa M. Solis
Publikováno v:
J Natl Cancer Inst
Background Approximately 20% of lung adenocarcinoma (LUAD) is negative for the lineage-specific oncogene Thyroid transcription factor 1 (TTF-1) and exhibits worse clinical outcome with a low frequency of actionable genomic alterations. To identify mo
Autor:
Guangchun Han, Warapen Treekitkarnmongkol, Ansam Sinjab, Tina Cascone, Jichao Chen, Humam Kadara, Ignacio I. Wistuba, Christopher S. Stevenson, Paul Scheet, Edwin R. Parra, Patrick M. Brennan, Luisa M. Solis, Carmen Behrens, Daniel G. Rosen, Jianjun Zhang, Danielle R. Little, Dapeng Hao, Beatriz Sanchez-Espiridion, Ruiping Wang, Linh M. Tran, Kostyantyn Krysan, Junya Fujimoto, John V. Heymach, Seyed Javad Moghaddam, Kieko Hara, Samer Bazzi, Minghao Dang, Avrum Spira, Kyle Chang, Dzifa Y. Duose, Don L. Gibbons, Boris Sepesi, Steven M. Dubinett, Linghua Wang, Elena Bogatenkova, Edwin J. Ostrin, Maria Gabriela Raso, Lauren Averett Byers, Jiexin Zhang, Hitoshi Dejima, Enyu Dai, Junya Fukuoka
Publikováno v:
Cancer Discov
Little is known of the geospatial architecture of individual cell populations in lung adenocarcinoma (LUAD) evolution. Here, we perform single-cell RNA sequencing of 186,916 cells from five early-stage LUADs and 14 multiregion normal lung tissues of
Autor:
John V. Heymach, Barbara Mino, J. Jack Lee, Pedro Rocha, Cesar A. Moran, David C. Rice, Edwin R. Parra, Humam Kadara, Boris Sepesi, Lei Feng, Luisa M. Solis, Carmen Behrens, Ignacio I. Wistuba, Don L. Gibbons, Jianjun Zhang, Chad J. Creighton, Jaime Rodriguez-Canales
Publikováno v:
Clinical Lung Cancer. 22:e415-e424
Introduction Immune infiltration in lung adenocarcinomas (LUADs) has been associated with response to immune checkpoint inhibitors. Clinical features underlying differential responses of patients with LUADs to immunotherapy are not well understood. H
Autor:
Runzhe Chen, Boris Sepesi, Jie Ye, J. Jack Lee, John V. Heymach, Junya Fujimoto, Baili Zhang, Nicholas McGranahan, Jianhua Zhang, Latasha Little, Junya Fukuoka, Harvey I. Pass, Dzifa Y. Duose, Chi Wan Chow, Hitoshi Dejima, Kazuhiro Tabata, Humam Kadara, Alexandre Reuben, Marcos R. Estecio, Jiexin Zhang, Xin Hu, Ara A. Vaporciyan, Jia Wu, Lisha Ying, Curtis Gumbs, Hoa H.N. Pham, Paul Scheet, Myrna C.B. Godoy, Carmen Behrens, Cara Haymaker, P. Andrew Futreal, Dan Su, Jianjun Zhang, Luisa M. Solis, Shawna M Hubert, Edwin R. Parra, Ignacio I. Wistuba, Mara B. Antonoff
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung adenocarcinoma (ADC) is unknown. In this study, we characterize the immune contexture of invasive lung ADC and its precursors by transcriptomic immune profiling, T cell r
Autor:
Pedro Rocha, Dzifa Y. Douse, Lixia Diao, Humam Kadara, Jianjun Zhang, Debora A. Ledesma, Jose Luis Solorzano, John V. Heymach, Ruth Salazar, Luisa M. Solis, Neda Kalhor, Barbara Mino, J. Jack Lee, Don L. Gibbons, Cesar A. Moran, David C. Rice, Carmen Behrens, Pamela Villalobos, Ara A. Vaporciyan, Jiexin Zhang, Hitoshi Dejima, Annikka Weissferdt, Kyle G. Mitchell, Tina Cascone, Edwin Parra-Cuentas, Boris Sepesi, Xiuning Le, Ignacio I. Wistuba
Publikováno v:
Cancer Immunology, Immunotherapy
Introduction CD73 is a membrane-bound enzyme crucial in adenosine generation. The adenosinergic pathway plays a critical role in immunosuppression and in anti-tumor effects of immune checkpoint inhibitors (ICI). Here, we interrogated CD73 expression
Autor:
Wei Lu, Ignacio I. Wistuba, David W. Cescon, Lin Zheng, Tak W. Mak, Pamela Villalobos, Jennifer Silvester, Lisa Maria Mustachio, Barbara Mino, Ethan Dmitrovsky, Luisa M. Solis, Zibo Chen, Masanori Kawakami, Kelsie L. Thu, Xi Liu, Carmen Behrens, Jonathan M. Kurie, Yulong Chen, Jaime Rodriguez-Canales, Jason Roszik
Publikováno v:
Molecular Cancer Therapeutics. 18:1775-1786
The spindle assembly checkpoint maintains genomic integrity. A key component is tyrosine threonine kinase (TTK, also known as Mps1). TTK antagonism is hypothesized to cause genomic instability and cell death. Interrogating The Cancer Genome Atlas rev
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Lung cancer, frequently presents with advanced stage disease with approximately 15–30% of patients first diagnosed by a malignant pleural effusion (MPE).Currently, we have limited understanding of the cellular complex immune landscape co
Autor:
Barbara Mino, J. Jack Lee, John V. Heymach, David C. Rice, Lixia Diao, Boris Sepesi, Luisa M. Solis, Debora A. Ledesma, Ruth Salazar, Humam Kadara, Ignacio I. Wistuba, Pamela Villalobos, Neda Kalhor, Cesar A. Moran, Annikka Weissferdt, Xiuning Le, Don L. Gibbons, Pedro Rocha, Dzifa Y. Douse, Carmen Behrens, Edwin Parra-Cuentas, Ara A. Vaporciyan, Hitoshi Dejima, Kyle G. Mitchell, Jianjun Zhang, Jiexin Zhang, Tina Cascone, Jose Luis Solorzano
Publikováno v:
Cancer Immunology, Immunotherapy. 70:1977-1978
The original version of this article unfortunately contained a mistake.
Autor:
Li Xu, Edwin R. Parra, Alexandre Reuben, Zahraa Rahal, Wei Lu, Carmen Behrens, Kieko Hara, Edwin J. Ostrin, Maria Gabriela Raso, Tina McDowell, Ignacio I. Wistuba, Junya Fukuoka, Luisa M. Solis, Kyle Chang, Florencia McAllister, Jiexin Zhang, Paul Scheet, Warapen Treekitkarnmongkol, Tina Cascone, Humam Kadara, Sayuri Nunomura-Nakamura, Jianling Zhou, Shanshan Deng, Smruthy Sivakumar, Seyed Javad Moghaddam, Joshua K. Ochieng, Junya Fujimoto, Avrum Spira, Maya Hassane, Jacob Kantrowitz, Ansam Sinjab, Wenhua Lang
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Early pathogenesis of lung adenocarcinoma (LUAD) remains largely unknown. We found that, relative to wild-type littermates, the innate immunomodulator Lcn2 (lipocalin-2) was increased in...