Zobrazeno 101 - 110
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Autor:
Peio Errarte, María C. Etxezarraga, Alberto Loizate, Gorka Larrinaga, Itxaro Perez, Begoña Sanz, Maider Beitia, Jon Danel Solano-Iturri, Aintzane Asumendi
Publikováno v:
International Journal of Medical Sciences
Background and Objective: Colorectal cancer (CRC) is a major health problem in developed countries. Adenomatous lesions in the large bowel are the main precursors of CRC and the adenoma-adenocarcinoma sequence still provides a solid model for researc
Autor:
Khaled Elnaghi, Amira Kamal El-Hawary, Renzo Boldorini, Abd Al-Rahman Mohammad Foda, Andrea Palicelli, Abdelhadi M. Shebl
Publikováno v:
Indian Journal of Pathology and Microbiology, Vol 62, Iss 3, Pp 405-412 (2019)
BASE-Bielefeld Academic Search Engine
BASE-Bielefeld Academic Search Engine
Background: There are several DNA repair pathways that protect cellular DNA from injury, such as nucleotide excision repair (NER) and mismatch repair (MMR). The protein product of the excision repair cross-complementation group 1 (ERCC1) gene plays a
Autor:
Gabriel Acosta-Gonzalez, Jonathan N. Glickman, Kara Lombardo, Shaolei Lu, Madhu M. Ouseph, Murray B. Resnick
Publikováno v:
Human Pathology. 83:115-123
The serrated neoplasia pathway accounts for approximately 20% of colorectal carcinomas (CRCs). Sessile serrated adenomas (SSAs), the main precursor lesion of the serrated pathway, are molecularly driven by MLH1 promoter methylation and microsatellite
Autor:
Bogusław Kędra, Magdalena Baszun, Marcin Nizioł, Wioletta Romaniuk, Konrad Zaręba, Justyna Zińczuk, Dorota Kamińska, Anna Pryczynicz, Katarzyna Guzińska-Ustymowicz
Publikováno v:
International Journal of Medical Sciences
Aims: Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are members of the glycosylphosphatidylinositol (GPI)-linked immunoglobulin (Ig) superfamily and take part in regulation of cell adhesion, tumor suppression and angiogenesis. Ov
Publikováno v:
Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
The Saudi Journal of Gastroenterology, Vol 25, Iss 1, Pp 46-54 (2019)
The Saudi Journal of Gastroenterology, Vol 25, Iss 1, Pp 46-54 (2019)
Background/Aim: Homeobox D4 (HOXD4) belongs to the homeobox (HOX) family, which plays a crucial role in the early embryo development and cell differentiation. The role of HOXD4 in human gastric adenocarcinoma has not been elucidated. In the present s
Autor:
Junhun Cho, Kyoung-Mee Kim, Woo Yong Lee, Won Ki Kang, Sang Yun Ha, Hee-Cheol Kim, Young Suk Park
Publikováno v:
Pathology - Research and Practice. 215:171-176
Tumor associated glycoprotein 72 (TAG-72) is a membrane-bound glycoprotein complex that is overexpressed in many adenocarcinomas. Recently, monoclonal antibody targeting TAG72, minretumomab, have been introduced as a potential therapeutic target in c
Publikováno v:
Indian Journal of Pathology and Microbiology, Vol 62, Iss 3, Pp 433-436 (2019)
Background: C-ros oncogene 1, receptor tyrosine kinase (ROS 1) proto-oncogene 1, receptor tyrosine kinase (ROS-1) fusions are potent oncogenic drivers and these re-arrangements promote signal transduction programs leading to uninhibited cell survival
Autor:
Elena Ryzhova, Dahui Qin, Domenico Coppola, Mohammad Shahid, James Saller, Dapeng Wang, Anthony M. Magliocco
Publikováno v:
Cancer Genomics - Proteomics. 16:267-272
Background/aim To report a case of mixed medullary/mucinous adenocarcinoma with unusual mutational gene profile. Patients and methods A 79-year-old female was diagnosed with a colorectal carcinoma of the transverse colon. The diagnostic work-up of th
Autor:
Tetsunari Oyama, Takayuki Asao, Hideki Endoh, Masayuki Sugano, Osamu Kawashima, Shigefumi Tanaka, Akira Shimizu, Kyoichi Kaira, Mitsuhiro Kamiyoshihara, Kimihiro Shimizu, Yoshihito Kogure, Kazuyoshi Imaizumi, Atsushi Fujita, Akira Mogi
Publikováno v:
Anticancer Research. 39:395-403
Background/aim The β2-adrenergic receptor (β2AR) is highly expressed in various human cancers and has been linked to tumor growth and metastases. Although β2AR is considered a novel therapeutic target of human neoplasms, the clinicopathological si
Publikováno v:
American Journal of Surgical Pathology. 42:1686-1692
Intestinal-type colorectal adenocarcinomas are graded based on extent of glandular differentiation, although mucinous, signet-ring cell, and solid cancers are, by convention, classified as high grade. Mismatch repair-deficient tumors frequently show