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pro vyhledávání: ''
Autor:
Hakan Alakus, Alexander Quaas, Reinhard Buettner, Christiane J. Bruns, Wolfgang Schröder, Max Krämer, Florian Gebauer, Heike Loeser, Philipp Lohneis, Martin Thelen, Hans A. Schlößer, Thomas Zander
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose Lymphocyte activation gene-3 (LAG3) is an immunosuppressive checkpoint molecule expressed on T cells. The frequency and distribution of LAG3 expression in oesophageal adenocarcinoma (EAC) is unknown. Aim of the study was the evaluation and di
Autor:
Godefridus J. Peters, Niccola Funel, Giulia Mantini, Claudio Ricci, Elisa Giovannetti, Btissame El Hassouni, Jessica Infante
Publikováno v:
Anticancer Research, 39(7), 3609-3614. International Institute of Anticancer Research
Hassouni, B E L, Infante, J, Mantini, G, Ricci, C, Funel, N, Giovannetti, E & Peters, G J 2019, ' Uridine cytidine kinase 2 as a potential biomarker for treatment with RX-3117 in pancreatic cancer* ', Anticancer Research, vol. 39, no. 7, pp. 3609-3614 . https://doi.org/10.21873/anticanres.13508
Hassouni, B E L, Infante, J, Mantini, G, Ricci, C, Funel, N, Giovannetti, E & Peters, G J 2019, ' Uridine cytidine kinase 2 as a potential biomarker for treatment with RX-3117 in pancreatic cancer* ', Anticancer Research, vol. 39, no. 7, pp. 3609-3614 . https://doi.org/10.21873/anticanres.13508
Background/aim The novel cytidine analog RX-3117, which is activated by uridine-cytidine kinase 2 (UCK2), shows encouraging activity in pancreatic and bladder cancer Phase IIa studies. In this study we highlight the potential role of UCK2 as a biomar
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
BACKGROUND Lung adenocarcinoma (LAC) accounts for the majority of lung cancer, which is the leading cause of cancer-related mortality worldwide. Keratin 17 (KRT17) was reported to promote the tumor development of skin tumor and oral cancer. The aim o
Publikováno v:
Genes, Chromosomes and Cancer. 57:240-251
The present study aims to examine promoter methylation status of FAM134B in a large cohort of patients with colorectal adenocarcinomas. The clinical significances and correlations of FAM134B promoter methylation with its expression are also analysed.
Autor:
Kazuto Harada, Neda Kalhor, Donald A. Berry, Dilsa Mizrak Kaya, Jeffrey H. Lee, Yusuke Shimodaira, Stephen G. Swisher, Quan Lin, Elena Elimova, Ailing W. Scott, Jaffer A. Ajani, Xuemei Wang, Shumei Song, Brian Weston, Wayne L. Hofstetter, David C. Rice, Manoop S. Bhutani, Veerabhadran Baladandayuthapani, Bin Liu, Heath D. Skinner, Roopma Wadhwa, Dipen M. Maru, Hironori Shiozaki
Publikováno v:
British Journal of Cancer
Background: Predictive biomarkers or signature(s) for oesophageal cancer (OC) patients undergoing preoperative therapy could help administration of effective therapy, avoidance of ineffective ones, and establishment new strategies. Since the hedgehog
Autor:
Mathilda Jing Chow, Nicholas Wong, Judy Yan, Anil Kapoor, Tariq Aziz, Jean-Claude Cutz, Damu Tang, Mingxing Zheng, Dulitha Jayasekera, Fengxiang Wei, Pierre Major
Publikováno v:
Oncotarget
Evidence supports the upregulation of MUC1 in prostate cancer (PC). However, this has not been thoroughly investigated. We report here an association of MUC1 upregulation with PC metastasis and the development of castration resistant PC (CRPC). MUC1
Publikováno v:
Medical oncology (Northwood, London, England). 36(11)
The vasoactive intestinal peptide receptor-1(VIPR1) has prominent growth effects on a number of common neoplasms. However, there were contradictions in the effect cross different cancers. We aimed to explore the effect of VIPR1 overexpression on a hu
Autor:
Takehisa Suzuki, Kenichi Ohashi, Mai Matsumura, Yu Nakashima, Yoko Tateishi, Tatsuro Irimura, Hideaki Mitsui, Kaori Denda-Nagai, Chihiro Koike, Toshiaki Kataoka, Shigeaki Umeda, Hiromasa Arai, Koji Okudela
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215237 (2019)
We investigated the significance of MUC21 in EGFR-mutated lung adenocarcinoma (LADC). Two-hundred forty-one surgically resected LADCs (116 EGFR-mutated and 125 wild-type tumors) were examined for immunohistochemical expression of MUC21 protein. A pol
Publikováno v:
Journal of cancer research and clinical oncology. 145(6)
Cancer stem cells (CSC) and epithelial–mesenchymal transition (EMT) pathways are crucial for cancer progression. However, synergistic interactions between CSC and EMT are not clear in non-small cell lung cancer (NSCLC). The objective of this study
Autor:
Amirnader Emami Razavi, Mohammad Hassan Emami, Ali Gheysarzadeh, A. H. Ansari, Mohammad Reza Mofid
Publikováno v:
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 19(3)
Low-density lipoprotein receptor-Related Protein-1 (LRP-1) has been reported to involve in tumor development. However, its role in pancreatic cancer has not been elucidated. The present study was designed to evaluate the expression of LRP-1 in Pancre