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Publikováno v:
Human Pathology. 119:51-58
Oncogenic mutations in the adenomatous polyposis coli (APC)/Wnt signaling pathway are well documented. The FBXW7 gene (F-box and WD repeat domain-containing 7) encodes a member of the ubiquitin-proteasome complex that is more recently described to an
Autor:
Robert-Jan van Suylen, T. Dorine den Toom, PALGA-group, Wim Timens, B. Hermans, Ernst-Jan M. Speel, Lisa M. Hillen, Jan H. von der Thüsen, Peggy N. Atmodimedjo, Esther C. van den Broek, Irene van der Baan, Jules L. Derks, Winand N.M. Dinjens, Cecile Coumans-Stallinga, Anne-Marie C. Dingemans, Hendrikus J. Dubbink
Publikováno v:
International Journal of Cancer, 150(5), 802-815. Wiley
International Journal of Cancer, 150(5), 802-815. Wiley-Liss Inc.
International Journal of Cancer, 150(5), 802-815. Wiley-Liss Inc.
Up to 14% of large cell neuroendocrine carcinomas (LCNEC) are diagnosed in continuity with non-small cell lung carcinoma. In addition to these combined lesions, 1-7% of lung tumors present as co-primary tumors with multiple synchronous lesions. We ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f50ecc92cc08af780025713f1572257
https://cris.maastrichtuniversity.nl/en/publications/d5126496-67b4-45b4-8479-7b3373cbeb02
https://cris.maastrichtuniversity.nl/en/publications/d5126496-67b4-45b4-8479-7b3373cbeb02
Autor:
Junyi Ye, Shanai Song, Haiwei Du, Zhou Zhang, Haiyan Li, Ning Liu, Zimin Liu, Xiaoxiao Li, Lu Zhang, Mingpeng Shi
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose The identification of HER2 overexpression in a subset of gastric adenocarcinoma (GA) patients represents a significant step forward in unveiling the molecular complexity of this disease. The predictive and prognostic value of HER2 amplificati
Autor:
Shivani Soni, Joanne Xiu, Wu Zhang, Curtis Johnston, John L. Marshall, Francesca Battaglin, W. Michael Korn, Heinz-Josef Lenz, Joshua Millstein, Jingyuan Wang, Andreas Seeber, Richard M. Goldberg, Natsuko Kawanishi, Philip A. Philip, Yasmine Baca, Jimmy J. Hwang, Anthony F. Shields, Hiroyuki Arai
Publikováno v:
Mol Cancer Ther
Goblet cell carcinoid (GCC) is a distinct subtype of appendiceal neoplasm that exhibits unique clinical and pathologic features. We aimed to reveal the molecular profiles of GCC compared with other appendiceal tumors, such as adenocarcinomas and neur
Autor:
Kazuya Shinmura, Yuji Iwashita, Masayuki Tanahashi, Kazuhito Funai, Haruhiko Sugimura, Takafumi Suda, Katsuhiro Yoshimura, Naoki Inui, Hiroshi Niwa, Masato Karayama, Hidetaka Yamada, Akikazu Kawase, Yusuke Inoue, Hiroshi Ogawa, Kazuo Tsuchiya
Publikováno v:
Lung Cancer. 141:21-31
Alterations in the MET gene, such as mutations and high-level amplification, are important drivers of non-small cell lung cancer (NSCLC). The efficacy of immune checkpoint inhibitors (ICIs) in lung cancer with MET abnormalities is unclear. We evaluat
Autor:
Yusuke Shinchi, Daiki Yoshii, Koei Ikeda, Makoto Suzuki, Takuro Sakagami, Yoshihiro Komohara, Yusuke Tomita, Eri Matsubara, Kensaku Sato, Yukio Fujiwara, Koji Ohnishi, Remi Mito
Publikováno v:
Pathology International. 70:287-294
Tumor-associated calcium signal transducer 2 (TROP2) is a cell-surface glycoprotein involved in the high malignant potential of several cancers. Antibody-drug conjugates that target TROP2 represent a promising approach for the treatment of TROP2-expr
Autor:
Wei-Hsun Hsu, Ching-Yao Yang, Chong-Jen Yu, Jih-Hsiang Lee, Kuan-Yu Chen, Tzu-Hsiu Tsai, Chia-Lin Hsu, Chao-Chi Ho, Wei-Yu Liao, Kang-Yi Su, Bin-Chi Liao, Chia Chi Hsu, Chen-Tu Wu, James Chih-Hsin Yang, Yih-Leong Chang, Jin-Yuan Shih, Chia-Chi Lin
Publikováno v:
European Journal of Cancer. 124:110-122
Besides being a predictive biomarker of response to immunotherapy in lung cancer in general, programmed death-ligand 1 (PD-L1) is not so well correlated with treatment outcomes of lung adenocarcinoma (ADC) harbouring epidermal growth factor receptor
Autor:
Anke Behnke, Denise Treue, Philipp Jurmeister, Leonille Schweizer, Maximilian von Laffert, Claudia Vollbrecht, Nikolaj Frost, Jens-Carsten Rückert, David Horst, Jens Neudecker, Frederick Klauschen, Manfred Dietel, Alexander Arnold, Michael Hummel
Publikováno v:
Lung Cancer. 138:43-51
Objectives We aim to provide a better understanding of the molecular landscape of primary lung adenocarcinomas with intestinal differentiation. Material and Methods Five invasive mucinous adenocarcinomas (IMA) and seven pulmonary enteric adenocarcino
Autor:
Kazuhiko Fujii, Sho Saeki, Yuki Tenjin, Takaaki Ito, Hidenori Ichiyasu, Yusuke Tomita, Koichi Saruwatari, Shiho Ishizuka, Takuro Sakagami, Ryo Sato, Kazuyoshi Nakamura
Publikováno v:
Internal Medicine
Small cell lung cancer (SCLC) transformation of epidermal growth factor receptor (EGFR) mutant adenocarcinoma (ADC) during EGFR tyrosine kinase inhibitor (TKI) treatment is an example of a rare subset of acquired drug resistance. We herein report the
Autor:
Judith Martha Neumann, Michail Galanis, Karsten Niehaus, Martin Griesshammer, Udo Kellner, Jasmin Saskia Hartmann, Hanna Bednarz, Hinrich Freitag
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose Most cancer-related deaths worldwide are associated with lung cancer. Subtyping of non-small cell lung cancer (NSCLC) into adenocarcinoma (AC) and squamous cell carcinoma (SqCC) is of importance, as therapy regimes differ. However, convention