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Autor:
Jochim Reinert, Nils W Engel, Judith Dierlamm, Walter Fiedler, Claudia Langebrake, Caroline Krüger, Carsten Bokemeyer, Winfried H. Alsdorf
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 40:479-483
Delayed methotrexate (MTX) elimination after treatment with high-dose (HD) MTX may result in life-threatening toxicities as well as acute kidney injury (AKI). Treatment includes administration of glucarpidase, an enzyme that rapidly inactivates MTX.