Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Clare M. Waterman"'
Publikováno v:
Dev Biol
Single cell branching during development in vertebrates is typified by neuronal branching to form neurites and vascular branches formed by sprouting angiogenesis. Neurons and endothelial tip cells possess subcellular protrusions that share many commo
Autor:
Anne E. Goldman, Clare M. Waterman, Denisa D. Wagner, Robert D. Goldman, Amir Vahabikashi, Hawa Racine Thiam, Mark Kittisopikul, Rong Qiu, Siu Ling Wong
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
We used quantitative, high-resolution live-cell imaging of neutrophil-like human cells (dHL60) and mouse and human blood-derived polymorphonuclear neutrophils (PMNs) stimulated with ionomycin, lipopolysaccharide (LPS), or Candida albicans to identify
Autor:
Clare M. Waterman, Rui Gong, Lucas Axiotakis, Santiago Reyes, Xiaoyu Sun, Mark A. Smith, Donovan Y.Z. Phua, Robert C. Cail, Mary C. Beckerle, Elizabeth Blankman, Gregory M. Alushin
Publikováno v:
Dev Cell
SummaryMechanical signals transmitted through the cytoplasmic actin cytoskeleton must be relayed to the nucleus to control gene expression. LIM domains are protein-protein interaction modules found in cytoskeletal proteins and transcriptional regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f333de7d841b93f6f36a14b2837756e
https://doi.org/10.1101/2020.03.06.979245
https://doi.org/10.1101/2020.03.06.979245
Autor:
Shalin B. Mehta, Vinay Swaminathan, David Baker, Talley J. Lambert, Pontus Nordenfelt, Jennifer C. Waters, Joseph Mathew Kalappurakkal, Timothy A. Springer, Clare M. Waterman, Tomomi Tani, Travis I. Moore, Rudolf Oldenbourg, Nobuyasu Koga, Satyajit Mayor
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here, we test whether the integrin, when engaged to an extracellular ligand and the cytoskeleton, adopts a specific orientation d
Publikováno v:
Biophysical Journal
Focal adhesions (FAs) are integrin-based transmembrane assemblies that connect a cell to its extracellular matrix (ECM). They are mechanosensors through which cells exert actin cytoskeleton-mediated traction forces to sense the ECM stiffness. Interes
Actomyosin Cortical Mechanical Properties in Nonadherent Cells Determined by Atomic Force Microscopy
Publikováno v:
Biophysical Journal. 110:2528-2539
The organization of filamentous actin and myosin II molecular motor contractility is known to modify the mechanical properties of the cell cortical actomyosin cytoskeleton. Here we describe a novel method, to our knowledge, for using force spectrosco
Vinculin is an actin-binding protein thought to reinforce cell-cell and cell-matrix adhesions. However, how mechanical load affects the vinculin-F-actin bond is unclear. Using a single-molecule optical trap assay, we found that vinculin forms a force
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523df21e23589f0a8511ddd82ec6570d
https://europepmc.org/articles/PMC6145086/
https://europepmc.org/articles/PMC6145086/
Autor:
Liang Gao, Viola Kraus, Michael W. Davidson, Bi-Chang Chen, Nikta Fakhri, Clare M. Waterman, Ingo Thievessen, R. Scott McIsaac, Julian Steinwachs, Eric Betzig, Ben Fabry, Rudolf Oldenbourg, Michelle A. Baird
Publikováno v:
The FASEB Journal. 29:4555-4567
Vinculin is filamentous (F)-actin-binding protein enriched in integrin-based adhesions to the extracellular matrix (ECM). Whereas studies in 2-dimensional (2D) tissue culture models have suggested that vinculin negatively regulates cell migration by
Autor:
Lindsay B. Case, Michael W. Davidson, Sharon L. Campbell, Harald F. Hess, Gleb Shtengel, Michelle A. Baird, Clare M. Waterman
Publikováno v:
Nature cell biology
Focal adhesions (FAs) link the extracellular matrix (ECM) to the actin cytoskeleton to mediate cell adhesion, migration, mechanosensing and signaling. FAs have conserved nanoscale protein organization, suggesting that the position of proteins within
Autor:
Alice E. Zemljic-Harpf, Clare M. Waterman, Sharon L. Campbell, S. Berlemont, Karen M. Plevock, Robert S. Ross, Peter M. Thompson, Sergey V. Plotnikov, Michael W. Davidson, Gaudenz Danuser, Ingo Thievessen
Publikováno v:
The Journal of Cell Biology
Vinculin functions as a molecular clutch that organizes leading edge F-actin, generates traction, and promotes focal adhesion formation and turnover but not adhesion growth.
In migrating cells, integrin-based focal adhesions (FAs) assemble in pr
In migrating cells, integrin-based focal adhesions (FAs) assemble in pr