Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Michael J. Welsh"'
Autor:
Levi P. Sowers, John A. Wemmie, Yimo Wang, Jianyang Du, Ali Ghobbeh, Rebecca J. Taugher, Caitlin V. Cosme, Yuan Lu, Ryan T. LaLumiere, Collin J. Kreple, Jason J. Radley, Madeliene Stump, Andrea L Schwager-Gutman, Rong Fan, Michael J. Welsh
Publikováno v:
Nature neuroscience
Acid-sensing ion channel 1A (ASIC1A) is abundant in the nucleus accumbens (NAc), a region known for its role in addiction. Because ASIC1A has been suggested to promote associative learning, we hypothesized that disrupting ASIC1A in the NAc would redu
Autor:
John A. Wemmie, George B. Richerson, Huiyu Gong, Jacob R. Kundert, Luisa Bernardinelli, Meredith G. Parsons, Margaret P. Price, Gordon F. Buchanan, Michael J. Welsh, Leah R. Reznikov, Martin D. Cassell, Kathryn Chaloner
Publikováno v:
Genes, Brain and Behavior. 13:179-194
Acid-sensing ion channels (ASICs) generate H(+) -gated Na(+) currents that contribute to neuronal function and animal behavior. Like ASIC1, ASIC2 subunits are expressed in the brain and multimerize with ASIC1 to influence acid-evoked currents and fac
Autor:
Omar A. Jaffer, Ryan J. Adam, Michael J. Welsh, David K. Meyerholz, David A. Stoltz, Mahmoud H. Abou Alaiwa, Margaret P. Price, Linda S. Powers, Leah R. Reznikov, Andrew S. Michalski
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166089 (2016)
PLoS ONE
PLoS ONE
Neurons innervating the airways contribute to airway hyperreactivity (AHR), a hallmark feature of asthma. Several observations suggested that acid-sensing ion channels (ASICs), neuronal cation channels activated by protons, might contribute to AHR. F
Autor:
Michael J. Welsh, Adam E. Ziemann, John A. Wemmie, Mikael K. Schnizler, Jianyang Du, Amanda M. Wunsch, Margaret P. Price, V. C. Vralsted
Publikováno v:
Genes, Brain, and Behavior
Previous studies on mice with a disruption of the gene encoding acid-sensing ion channel 1a (ASIC1a) suggest that ASIC1a is required for normal fear behavior. To investigate the effects of altering the subunit composition of brain ASICs on behavior,
Autor:
Heather A. Drummond, Yongjun Lu, Christopher J. Benson, Rasna Sabharwal, Michael J. Welsh, Carol A. Whiteis, Donald A. Morgan, Vladislav Snitsarev, Kamal Rahmouni, Xiuying Ma, Margaret P. Price, Francois M. Abboud, Vivian Costa, Mark W. Chapleau
Publikováno v:
Neuron. 64:885-897
SummaryArterial baroreceptors provide a neural sensory input that reflexly regulates the autonomic drive of circulation. Our goal was to test the hypothesis that a member of the acid-sensing ion channel (ASIC) subfamily of the DEG/ENaC superfamily is
Autor:
Vivian Costa, Xiang-ming Zha, Christopher J. Benson, Anne Marie S. Harding, Leah R. Reznikov, Michael J. Welsh
Publikováno v:
Journal of Neuroscience. 29:8438-8446
Acid-sensing ion channel-1a (ASIC1a) mediates H(+)-gated current to influence normal brain physiology and impact several models of disease. Although ASIC2 subunits are widely expressed in brain and modulate ASIC1a current, their function remains poor
Autor:
John A. Wemmie, Johannes W. Hell, Michael J. Welsh, Mikael K. Schnizler, Duane D. Hall, Xiang-ming Zha, Katrin Schnizler
Publikováno v:
The Journal of Biological Chemistry
The acid-sensing ion channel 1a (ASIC1a) is widely expressed in central and peripheral neurons where it generates transient cation currents when extracellular pH falls. ASIC1a confers pH-dependent modulation on postsynaptic dendritic spines and has c
Autor:
John A. Wemmie, Sandra Vergo, Michael J. Welsh, Lars Fugger, Matthew Craner, Ruth Etzensperger, Angela Vincent, Manuel A. Friese
Publikováno v:
Friese, MA, Cramer, MJ, Etzensperger, R, Vergo, S, Wemmie, JA, Welsh, MJ, Vincent, A & Fugger, L H 2007, ' Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system ', Nat. Med, vol. 13, no. 12, pp. 1483-1489 .
Multiple sclerosis is a neuroinflammatory disease associated with axonal degeneration. The neuronally expressed, proton-gated acid-sensing ion channel-1 (ASIC1) is permeable to Na+ and Ca2+, and excessive accumulation of these ions is associated with
Publikováno v:
Proceedings of the National Academy of Sciences. 103:16556-16561
Extracellular proton concentrations in the brain may be an important signal for neuron function. Proton concentrations change both acutely when synaptic vesicles release their acidic contents into the synaptic cleft and chronically during ischemia an
Publikováno v:
Trends in Neurosciences. 29:578-586
Extracellular acid can have important effects on neuron function. In central and peripheral neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular protons, and recent studies suggest diverse roles for these channel