Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Piotr Swiderski"'
Autor:
Sorah Yoon, Piotr Swiderski, John J. Rossi, Pinelopi Andrikakou, Mikael H. Sodergren, Nagy A. Habib, Vikash Reebye, Kai-Wen Huang, Daniel Vasconcelos
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 18, Iss, Pp 142-154 (2019)
Molecular Therapy: Nucleic Acids, Vol 18, Iss, Pp 142-154 (2019)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies; it preferentially metastasizes to the liver and is the main cause of death from this disease. In previous studies, small activating RNA against CCAAT/enhancer-binding
Autor:
Bin Zhang, Mhairi Copland, Herman Wu, Stephen J. Forman, Dandan Zhao, Ravi Bhatia, Huafeng Wang, Guido Marcucci, Le Xuan Truong Nguyen, Adrienne M. Dorrance, David S. Snyder, Piotr Swiderski, Tessa L. Holyoake, Ching-Cheng Chen, Vinod Pullarkat, Allen Lin, Bijender Kumar, Lisa E. M. Hopcroft, Tinisha McDonald, Haris Ali, Anthony S. Stein, Francesca Pellicano, Estelle Troadec, Danilo Perrotti, Nadia Carlesso, Casey J Brewer, Ya-Huei Kuo, Ling Li, Marcin Kortylewski, Calvin J. Kuo, Yu-Lin Su, Yate Ching Yuan
Publikováno v:
Nature medicine
Leukemia stem cells (LSCs) in individuals with chronic myelogenous leukemia (CML) (hereafter referred to as CML LSCs) are responsible for initiating and maintaining clonal hematopoiesis. These cells persist in the bone marrow (BM) despite effective i
Autor:
Hongwei H. Yin, Yong Liang, Larry W. Kwak, Haejung Won, Marcin Kortylewski, Raju Pillai, Zhuoran Zhang, Piotr Swiderski, Xingli Zhao, Dayson Moreira, Stephen J. Forman, Yu-Lin Su, Zhenyuan Dong, Tomasz Adamus
Publikováno v:
Molecular Therapy
Growing evidence links the aggressiveness of non-Hodgkin’s lymphoma, especially the activated B cell-like type diffuse large B cell lymphomas (ABC-DLBCLs) to Toll-like receptor 9 (TLR9)/MyD88 and STAT3 transcription factor signaling. Here, we descr
Autor:
Vittorio de Franciscis, Carla Lucia Esposito, Gianluca Santamaria, Gennaro De Vita, Silvia Catuogno, Laura Cerchia, Gerolama Condorelli, Paloma H. Giangrande, Piotr Swiderski, Justin P. Dassie
Publikováno v:
Molecular Therapy. 22:1151-1163
While microRNAs (miRNAs) clearly regulate multiple pathways integral to disease development and progression, the lack of safe and reliable means for specific delivery of miRNAs to target tissues represents a major obstacle to their broad therapeutic
Autor:
Zhuo Li, Weiying Zhou, Michael A. Reid, Shizhen Emily Wang, Amy Y. M. Chow, Mei Kong, George Somlo, Xiwei Wu, Sean Timothy Francis O’Connor, Jacob R. Tremblay, Piotr Swiderski, Melanie R. Palomares, Shasha Li, Xiubao Ren, Wenwan Zhong, Jonathan Ashby, Akihiro Tsuyada, Yuan Chen, Yanhong Shi, Andrew R. Chin, Guoqiang Sun, Manasa Chandra, Miranda Y. Fong, Liang Liu, Aileen Y. Alontaga
Publikováno v:
Nature Cell Biology. 17:183-194
Reprogrammed glucose metabolism as a result of increased glycolysis and glucose uptake is a hallmark of cancer. Here we show that cancer cells can suppress glucose uptake by non-tumour cells in the pre-metastatic niche, by secreting vesicles that car
Autor:
Dimitris Zacharoulis, Sorah Yoon, Nagy A. Habib, Isabella Reccia, John E. Shively, Konstantinos Dimas, John J. Rossi, Vikash Reebye, Brian Armstrong, Yijie Wang, Piotr Swiderski, Duncan Spalding, Kai-Wen Huang, Tomokazu Kusano, Lin Li, Teresa M. Przytycka
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss, Pp 80-88 (2017)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Aptamer-drug conjugates (ApDCs) have the potential to improve the therapeutic index of traditional chemotherapeutic agents due to their ability to deliver cytotoxic drugs specifically to cancer cells while sparing normal cells. This study reports on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900c0322d21eb96c8f465bf1fb2a094b
http://hdl.handle.net/10044/1/46025
http://hdl.handle.net/10044/1/46025
Autor:
Ling Peng, Vikash Reebye, Malkhaz Mizandari, Mohamed Emara, Xiaoxuan Liu, Dimitris Zacharoulis, Cheng Liu, Madhava Pai, Duncan Spalding, Steen Lindkær-Jensen, John J. Rossi, Joanna Nicholls, Pål Sætrom, Nikolaos Kostomitsopoulos, Noriyuki Kasahara, Nagy A. Habib, Kai-Wen Huang, Paul J. Mintz, Abdelali Haoudi, Donald A. Tomalia, Piotr Swiderski, Tinatin Chikovani, Long R. Jiao
Publikováno v:
Hepatology. 59:216-227
Hepatocellular carcinoma (HCC) occurs predominantly in patients with liver cirrhosis. Here we show an innovative RNA-based targeted approach to enhance endogenous albumin production while reducing liver tumor burden. We designed short-activating RNAs
Autor:
C. Preston Neff, Ramesh Akkina, Jane Zhang, Jiehua Zhou, Yuanyu Huang, David D. Smith, Quan Du, Ling Peng, Xiaoxuan Liu, Zicai Liang, Piotr Swiderski, Tawfik A. Aboellail, John J. Rossi, Haitang Li
Publikováno v:
Molecular Therapy. 19(12):2228-2238
We evaluated the in vivo efficacy of structurally flexible, cationic PAMAM dendrimers as a small interfering RNA (siRNA) delivery system in a Rag2(-)/-γc-/- (RAG-hu) humanized mouse model for HIV-1 infection. HIV-infected humanized Rag2-/-γc-/- mic
Autor:
Chunmei Yang, Jiehui Deng, Drew M. Pardoll, Lin Wang, Marcin Kortylewski, Piotr Swiderski, Harris S. Soifer, Andrew Raubitschek, Richard Jove, Maciej Kujawski, Anna Scuto, Heehyoung Lee, Claudia M. Kowolik, Hua Yu, Andreas Herrmann, Yong Liu, Stephen J. Forman, John J. Rossi
Publikováno v:
Nature Biotechnology
Nature biotechnology
Nature biotechnology
Efficient delivery of siRNA to specific cell populations in vivo remains a formidable challenge to its successful therapeutic application. We describe a novel siRNA-based approach – synthetically linking siRNA to an oligonucleotide TLR9 agonist –
Autor:
Haitang Li, Jane Zhang, C. Preston Neff, John J. Rossi, Ramesh Akkina, Jiehua Zhou, Piotr Swiderski
Publikováno v:
Nucleic Acids Research
The envelope glycoprotein of human immunodeficiency virus (HIV) consists of an exterior glycoprotein (gp120) and a trans-membrane domain (gp41) and has an important role in viral entry into cells. HIV-1 entry has been validated as a clinically releva