Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Mark A Wainberg"'
Publikováno v:
Journal of Medical Virology. 90:796-802
Zika virus (ZIKV) outbreak has emerged as a global health threat, particularly in tropical areas, over the past few years. No antiviral therapy or vaccine is available at present. For these reasons, repurposing clinically approved drugs against ZIKV
Autor:
Lothar Resch, Michael Gill, Glen B. Baker, Wing Fuk Chan, Oussama Meziane, Christopher Power, Éric A. Cohen, Eugene L. Asahchop, William G. Branton, Mark A. Wainberg, Manmeet K. Mamik, Jean V. Guimond, Elie Haddad
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-17 (2017)
Retrovirology
Retrovirology
Background In patients with HIV/AIDS receiving antiretroviral therapy (ART), HIV-1 persistence in brain tissue is a vital and unanswered question. HIV-1 infects and replicates in resident microglia and trafficking macrophages within the brain althoug
Autor:
Mark A. Wainberg, Hongtao Xu, Ruxandra-Ilinca Ibanescu, Thibault Mesplède, Bluma G. Brenner, Maureen Oliveira
Publikováno v:
Journal of Antimicrobial Chemotherapy. 72:3008-3011
Background 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) is a potent nucleoside analogue inhibitor of HIV that has an unusually long half-life. Cell culture selections with either EFdA or lamivudine using both subtype B and non-B clinical isolates sel
Autor:
Laurence Meyer, Julie Chas, Jean-Guy Baril, Véronique Doré, Michel Morin, Jean-Pierre Aboulker, Marine Saouzanet, Isabelle Durant-Zaleski, Marie Suzan-Monti, Emmanuelle Netzer, Françoise Euphrasie, Nathalie Bajos, Séverine Gibowski, Soizic Le Mestre, Gilles Peytavin, Jean-François Delfraissy, Constance Delaugerre, David Thompson, Brigitte Guillon, Gilles Pialoux, Alpha Diallo, Nicolas Etien, Christian Chidiac, Michel Besnier, Isabelle Charreau, Benoit Trottier, Baptiste Demoulin, Julie Timsit, Bruno Spire, Joanne Otis, Laurent Cotte, Julien Fonsart, W. Rozenbaum, Mark A. Wainberg, Gabriel Girard, Eric Cua, Guillemette Antoni, Daniela Rojas Castro, Catherine Capitant, Luis Sagaon-Teyssier, Antoine Cheret, Marie-Christine Simon, Cécile Tremblay, Nicolas Leturque, Johan Binesse, Diane Carette, Valérie Foubert, Anaïs Mennecier, Grégoire Cattin, Jean-Michel Molina, Yacine Saïdi, Nicolas Lorente, Elias Choucair, François Raffi, Cecile Rabian, Armelle Pasquet, Marie Préau, Thomas Huleux
Publikováno v:
The Lancet HIV
The Lancet HIV, 2020, 7 (2), pp.e113-e120. ⟨10.1016/S2352-3018(19)30341-8⟩
The Lancet HIV, 2020, 7 (2), pp.e113-e120. ⟨10.1016/S2352-3018(19)30341-8⟩
Summary Background ANRS IPERGAY found that on-demand pre-exposure prophylaxis (PrEP) with oral tenofovir disoproxil fumarate plus emtricitabine was associated with an 86% relative reduction of HIV-1 incidence compared with placebo among men who have
Publikováno v:
Pathogens and Immunity, Vol 1, Iss 1, Pp 41-67 (2016)
Pathogens & Immunity
Pathogens & Immunity
Since the discovery of the first inhibitors of HIV replication, drug resistance has been a major problem in HIV therapy, due, in part, to the high mutation rate of HIV. Therefore, the development of a predictive animal model is important to identify
Autor:
Hongtao Xu, Ying-Shan Han, Peter A. Crooks, Maureen Oliveira, Thibault Mesplède, Yudong Quan, Mark A. Wainberg, Narsimha Reddy Penthala
Publikováno v:
Journal of Medical Virology. 89:397-407
Dengue virus (DENV) causes a variety of difficult-to-treat diseases that threaten almost half of the world's population. Currently, no effective vaccine or antiviral therapy is available. We have examined a series of synthetic resveratrol analogs to
Autor:
Shan Cen, Qinghua Pan, Zhen Wang, Chen Liang, Fei Guo, Mark A. Wainberg, Weijun Zhu, Patrick Gendron
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 481-489 (2016)
SummaryCas9 cleaves specific DNA sequences with the assistance of a programmable single guide RNA (sgRNA). Repairing this broken DNA by the cell’s error-prone non-homologous end joining (NHEJ) machinery leads to insertions and deletions (indels) th
Autor:
Michel Roger, Gilbert Émond, Thomas Haig, Mark A. Wainberg, Joanne Otis, Bluma G. Brenner, Joseph Cox, Amélie McFadyen, Martin Blais, Robert Rousseau
Publikováno v:
AIDS and Behavior
Gay, bisexual, and other men who have sex with men (MSM) have adapted their sexual practices over the course of the HIV/AIDS epidemic based on available data and knowledge about HIV. This study sought to identify and compare patterns in condom use am
Autor:
Mark A. Wainberg, Bluma G. Brenner, Maureen Oliveira, Hongtao Xu, Nathan Osman, Simrat Bharaj, Thibault Mesplède, Ahmad Alikhani, Said Hassounah, Ruxandra-Ilinca Ibanescu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Animal models are essential to study novel antiretroviral drugs, resistance-associated mutations (RAMs), and treatment strategies. Bictegravir (BIC) is a novel potent integrase strand transfer inhibitor (INSTI) that has shown promising results agains
Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretrovirals to be approved for the treatment of HIV infection. Canonical resistance to these competitive inhibitors develops through substitutions in the integrase active site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e891e578b62b4218a96d32bdcc5ff37f
https://europepmc.org/articles/PMC5640858/
https://europepmc.org/articles/PMC5640858/