Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Cara Haymaker"'
Autor:
Ignacio I. Wistuba, M. Casarrubios, Gerardo Huidobro, Edel del Barco, A. Insa, Carlos Tarin, Fernando Franco, Alberto Cruz-Bermúdez, Cara Haymaker, Ernest Nadal, Mariano Provencio, Raquel Laza-Briviesca, Aránzazu García-Grande, Manuel Domine, Manuel Cobo, Margarita Majem, M.-R. García-Campelo, Atocha Romero, Reyes Bernabe Caro, Guillermo López Vivanco, Nuria Viñolas, Santiago Viteri, Delvys Rodriguez-Abreu, Bartomeu Massuti, Isidoro Barneto Aranda, Belén Sierra-Rodero, Alex Martinez-Marti, Javier de Castro Carpeño
Publikováno v:
Clinical and Translational Medicine
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Clinical and Translational Medicine, Vol 11, Iss 7, Pp n/a-n/a (2021)
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Clinical and Translational Medicine, Vol 11, Iss 7, Pp n/a-n/a (2021)
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Background Immunotherapy is being tested in early‐stage non‐small cell lung cancer (NSCLC), and achieving higher rates of complete pathological responses (CPR) as compared to standard of care. Early identification of CPR patients has vital clinic
Autor:
Marie Andrée Forget, Barbara Pazdrak, Yared Hailemichael, Meenu Sharma, Patrick Hwu, Cara Haymaker, Adi Diab, Binisha Karki, Ute Hoch, Christina Vianden, Deborah H. Charych, Manisha Singh, Caitlin Creasy, Cristian Coarfa, Michael E. Hurwitz, Salah Eddine Bentebibel, Mario Sznol, Uddalak Bharadwaj, Hiep Khong, Kimal Rajapakshe, Chantale Bernatchez, David J. Tweardy, Jonathan Zalevsky, Murali Addepalli, Srinivas Vennam, Faisal Fa’ak, Willem W. Overwijk, Shixia Huang, Louise M.E. Janssen, Brent C. Chesson, Laura Maria S. Kahn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
High dose interleukin-2 (IL-2) is active against metastatic melanoma and renal cell carcinoma, but treatment-associated toxicity and expansion of suppressive regulatory T cells (Tregs) limit its use in patients with cancer. Bempegaldesleukin (NKTR-21
Autor:
Marie-Andree Forget, Min Zhang, Rina M. Mbofung, Ashish Kalra, Timothy P. Heffernan, R. Eric Davis, Trang N. Tieu, Weiyi Peng, Florian L. Muller, Seram Devi, Cara Haymaker, Patrick Hwu, Chantale Bernatchez, Chengwen Liu, Soraya Zorro Manrique, Anil K. Sood, Chunyu Xu, Leila Williams, Nikunj Satani, Jodi A. McKenzie, Shruti Malu, Rodabe N. Amaria, Sunila Pradeep, Yuan Chen, Emily Ashkin, Lu Huang, Jason Roszik, Jianhua Hu
Publikováno v:
JNCI Journal of the National Cancer Institute
Background Immunotherapy has increasingly become a staple in cancer treatment. However, substantial limitations in the durability of response highlight the need for more rational therapeutic combinations. The aim of this study is to investigate how t
Autor:
Xingzhi Song, Ugur Sahin, Nir Friedman, Ronen Levy, Nouar Qutob, Itay Tirosh, Brett W. Carter, Eytan Ruppin, Yochai Wolf, Alexandre Reuben, Eilon Barnea, Polina Greenberg, Yardena Samuels, Caitlin Creasy, Tali Feferman, Arie Admon, Marie Andrée Forget, Steven A. Rosenberg, Tana Omokoko, Sushant Patkar, Guy Shakhar, Erez Greenstein, Xizeng Mao, Shelly Kalaora, Chantale Bernatchez, Jennifer A. Wargo, Cara Haymaker, Michal Lotem, Zachary A. Cooper, Ofra Golani, Dan Reshef, Jianhua Zhang, Juliane Quinkhardt
Publikováno v:
Cancer discovery. 8(11)
The quest for tumor-associated antigens (TAA) and neoantigens is a major focus of cancer immunotherapy. Here, we combine a neoantigen prediction pipeline and human leukocyte antigen (HLA) peptidomics to identify TAAs and neoantigens in 16 tumors deri
Autor:
Chantale Bernatchez, Shawne T. Thorsen, Audrey M. Gonzalez, Weiyi Peng, Shruti Malu, Seth Wardell, Arely Wahl, Rodabe N. Amaria, Esteban Flores, Cara Haymaker, Rene J. Tavera, Patrick Hwu, Renjith Ramachandran, Orenthial J. Fulbright, Chistopher Leroy Toth, Marie Andrée Forget, Minying Zhang
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology
Frontiers in Immunology
Following the clinical success achieved with the first generation of adoptive cell therapy (ACT) utilizing in vitro expanded tumor-infiltrating lymphocytes (TILs), the second and third generations of TIL ACT are evolving toward the use of genetically
Autor:
Yi Yang, Anupama Sahoo, Oanh N. Hoang, Roza Nurieva, Andrei Alekseev, Cara Haymaker, Hong Qin, Krit Ritthipichai, Shao Cong Sun, Yared Hailemichael, Qiang Zou, Sattva S. Neelapu, Willem W. Overwijk, Chantale Bernatchez, Tiejun Wang, Kimberly S. Schluns, Divyendu Singh, Larry W. Kwak, Junmei Wang
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
T-cell tolerance is a major obstacle to successful cancer immunotherapy; thus, developing strategies to break immune tolerance is a high priority. Here we show that expression of the E3 ubiquitin ligase Grail is upregulated in CD8+ T cells that have
Autor:
Edwin Roger Parra, Cara Haymaker, Jaime Rodriguez-Canales, Marie Andrée Forget, Naohiro Uraoka, Don L. Gibbons, Ignacio I. Wistuba, Mei Jiang, Chantale Bernatchez, Pamela Cook
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Immune-profiling is becoming an important tool to identify predictive markers for the response to immunotherapy. Our goal was to validate multiplex immunofluorescence (mIF) panels to apply to formalin-fixed and paraffin-embedded tissues using a set o
Autor:
Cara Haymaker, Michelle D. Williams, Sapna Pradyuman Patel, Zachary A. Cooper, Mariana Petaccia de Macedo, Bita Esmaeli, Wei Lien Wang, Rodabe N. Amaria, Alexandre Reuben, Orenthial J. Fulbright, Arely Wahl, Sujan T Reddy, Alexander J. Lazar, Yong Qin, Renjith Ramachandran, Patrick Hwu, Vancheswaran Gopalakrishnan, Esteban Flores, Michael T. Tetzlaff, Claudius Conrad, Rene J. Tavera, Marie Andrée Forget, Chantale Bernatchez, Jennifer A. Wargo, Shawne T. Thorsen, Christine N. Spencer, Dan S. Gombos
Publikováno v:
Oncoimmunology
OncoImmunology, Vol 6, Iss 6 (2017)
OncoImmunology, Vol 6, Iss 6 (2017)
The low response rates to immunotherapy in uveal melanoma (UM) sharply contrast with reputable response rates in cutaneous melanoma (CM) patients. To characterize the mechanisms responsible for resistance to immunotherapy in UM, we performed immune p
Autor:
Haven R. Garber, Xingzhi Song, Padmanee Sharma, Alexandria P. Cogdill, Brett W. Carter, Robert Sloane, Jeffrey E. Gershenwald, Xizeng Mao, Zachary A. Cooper, Mariana Petaccia de Macedo, Christine N. Spencer, Jacob Austin-Breneman, Michael A. Davies, Jason Roszik, Ignacio I. Wistuba, Hannah C. Beird, P. Andrew Futreal, Karen Clise-Dwyer, Rodabe N. Amaria, Peter A. Prieto, Curtis Gumbs, James P. Allison, Hong Jiang, Alexandre Reuben, Luigi Nezi, Alexander J. Lazar, Cara Haymaker, Jianhua Hu, Jianhua Zhang, Sapna Pradyuman Patel, Adi Diab, Sangeetha M. Reddy, Rebecca Thornton, Elizabeth A. Grimm, Scott E. Woodman, Latasha Little, Hussein Abdul-Hassan Tawbi, Courtney W. Hudgens, Marie Andrée Forget, Patrick Hwu, Pei Ling Chen, Michael T. Tetzlaff, Jiong Chen, Wei Shen Chen, Isabella C. Glitza, Lynda Chin, Chantale Bernatchez, Jennifer A. Wargo, Jeffrey E. Lee, Vancheswaran Gopalakrishnan, Khalida Wani, Eveline Chen, John P. Miller, Whijae Roh
Publikováno v:
NPJ Genomic Medicine
npj Genomic Medicine, Vol 2, Iss 1, Pp 1-11 (2017)
npj Genomic Medicine, Vol 2, Iss 1, Pp 1-11 (2017)
Appreciation for genomic and immune heterogeneity in cancer has grown though the relationship of these factors to treatment response has not been thoroughly elucidated. To better understand this, we studied a large cohort of melanoma patients treated
Autor:
Balakrishnan Ramesh, Victor G. Sendra, Melisa Martinez-Paniagua, Badrinath Roysam, Cara Haymaker, Ivan Liadi, Xingyue An, Laszlo Radvanyi, Gabrielle Romain, Yanbin Lu, Navin Varadarajan
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181904 (2017)
PLoS ONE
PLoS ONE
Natural killer (NK) cells are a highly heterogeneous population of innate lymphocytes that constitute our first line of defense against several types of tumors and microbial infections. Understanding the heterogeneity of these lymphocytes requires th