Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Richard A, Koup"'
Autor:
Jeffrey D. Lifson, John R. Mascola, Sean P. O’Brien, Theodora Hatziioannou, Paul D. Bieniasz, Jason Gorman, Brandon F. Keele, George M. Shaw, Gregory Q. Del Prete, Richard A. Koup, Taina T. Immonen, Adrienne E. Swanstrom, Christine M. Fennessey, Amarendra Pegu, Kathryn E. Foulds, Nicole A. Doria-Rose, Peter D. Kwong, Sung-Youl Ko, Mario Roederer, Carolyn Williamson, Stephen D. Schmidt, Hui Li
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting their utility. Furthermore,
Autor:
Patrick Younan, Mathieu Iampietro, Andrew Nishida, Palaniappan Ramanathan, Rodrigo I. Santos, Mukta Dutta, Ndongala Michel Lubaki, Richard A. Koup, Michael G. Katze, Alexander Bukreyev, John T. Patton
Publikováno v:
mBio
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific activatio
Autor:
Richard A. Koup, Patrick Younan, Mathieu Iampietro, Andrew Nishida, Mukta Dutta, Ndongala Michel Lubaki, Michael G. Katze, Rodrigo I. Santos, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006397 (2017)
PLoS Pathogens
PLoS Pathogens
Fatal outcomes of Ebola virus (EBOV) infections are typically preceded by a ‘sepsis-like’ syndrome and lymphopenia despite T cells being resistant to Ebola infection. The mechanisms that lead to T lymphocytes death remain largely unknown; however
Autor:
John R. Mascola, Barney S. Graham, Peter B. Gilbert, Hong Zhao, Steven Lepore, M. Juliana McElrath, Michal Juraska, Jerome H. Kim, Morgane Rolland, Allan C. deCamp, Hongjun Bai, James I. Mullins, Robert T. Bailer, Robert J. O'Connell, Breana Hall, Sodsai Tovanabutra, Richard A. Koup, Shelly Karuna, Annemarie O'Sullivan, Elizabeth Adams, Shana Miller, Daniel E. Geraghty, Eric Sanders-Buell, Hasan Ahmed, Craig A. Magaret, Lindsay N. Carpp, Kalpana Dommaraju, Mario Roederer, Scott M. Hammer, Lawrence Corey, Kultida Poltavee, Raphael Gottardo, Matthew Zirui Tay, Andrew Fiore-Gartland, Nelson L. Michael, Derrick Goodman, Kim G. Wong, Patricia D'Souza, Magdalena E. Sobieszczyk, Lisa M. Frenkel, Paul T. Edlefsen, Meera Bose, Sheila Styrchak, Georgia D. Tomaras, Lennie Chen, Merlin L. Robb, Nicole Frahm, James G. Kublin
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0185959 (2017)
PLoS ONE
PLoS ONE
Although the HVTN 505 DNA/recombinant adenovirus type 5 vector HIV-1 vaccine trial showed no overall efficacy, analysis of breakthrough HIV-1 sequences in participants can help determine whether vaccine-induced immune responses impacted viruses that
Autor:
Constantinos Petrovas, Manuel Leal, Rafael Luque, Diane V. Havlir, Kapil K. Saharia, Prudence Ive, Sara Ferrando-Martinez, Richard A. Koup, Anne F Luetkemeyer
Publikováno v:
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
PloS one, vol 11, iss 7
PLoS ONE, Vol 11, Iss 7, p e0158262 (2016)
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
PloS one, vol 11, iss 7
PLoS ONE, Vol 11, Iss 7, p e0158262 (2016)
[Background] Little is known about the expression of inhibitory molecules cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed-death-1 (PD-1) on Mycobacterium tuberculosis (Mtb)-specific CD4 T-cells and how their expression is impacted by TB trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d152ab4f9f6ccd7b0e32861f3e7c455
https://hdl.handle.net/10668/10229
https://hdl.handle.net/10668/10229
Autor:
Brigitte Autran, Rémi Cheynier, Yin Xu, Adrien Six, Arnaud Moris, Angeline Rouers, Lucie Colineau, Assia Samri, Alejandra Urrutia, Takuya Yamamoto, Anthony D. Kelleher, Stéphanie Graff-Dubois, Richard A. Koup, Sylvain Cardinaud, Karim Dorgham, Pierre-Grégoire Coulon, Anne Hosmalin, Eric Oksenhendler, John Zaunders, Hang-Phuong Pham
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, Vol 10, Iss 10, p e0140978 (2015)
PLoS ONE, Public Library of Science, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, Vol 10, Iss 10, p e0140978 (2015)
International audience; Follicular helper T (Tfh) cells within secondary lymphoid organs control multiple steps of B cell maturation and antibody (Ab) production. HIV-1 infection is associated with an altered B cell differentiation and Tfh isolated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b99955d4a70eff404e532fbe2a1260
https://www.hal.inserm.fr/inserm-01222249/file/journal.pone.0140978.pdf
https://www.hal.inserm.fr/inserm-01222249/file/journal.pone.0140978.pdf
Autor:
Eirini Moysi, Takuya Yamamoto, Robert Paris, Constantinos Petrovas, Sara Ferrando-Martinez, Kristin L. Boswell, Richard Haubrich, Eva Archer, David R. Ambrozak, Mark Connors, Joseph P. Casazza, Richard A. Koup, Julie A Ake, Jerome H. Kim
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0144767 (2015)
PLoS ONE, Vol 10, Iss 12, p e0144767 (2015)
The role of PD-1 expression on CD4 T cells during HIV infection is not well understood. Here, we describe the differential expression of PD-1 in CD127high CD4 T cells within the early/intermediate differentiated (EI) (CD27highCD45RAlow) T cell popula
Autor:
Ndongala Michel Lubaki, Patrick Younan, Rodrigo I Santos, Michelle Meyer, Mathieu Iampietro, Richard A Koup, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006031 (2016)
PLoS Pathogens
PLoS Pathogens
Ebola virus (EBOV) infections are characterized by deficient T-lymphocyte responses, T-lymphocyte apoptosis and lymphopenia. We previously showed that disabling of interferon-inhibiting domains (IIDs) in the VP24 and VP35 proteins effectively unblock
Autor:
Peter B. Gilbert, Mangala Rao, Erik Billings, Robert J. O'Connell, Nicos Karasavvas, Barton F. Haynes, Nelson L. Michael, Jerome H. Kim, Susan Zolla-Pazner, Abraham Pinter, Sorachai Nitayaphan, David C. Montefiori, Timothy Cardozo, Constance Williams, Mark de Souza, Daryl E. Morris, Supachai Rerks-Ngarm, Richard A. Koup, Charla Andrews, Raphael Gottardo, Phillip W. Berman, Merlin L. Robb, Xiaoying Shen, Bette T. Korber, Georgia D. Tomaras, Viseth Ngauy, Robert T. Bailer, Allan C. deCamp, John R. Mascola
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53629 (2013)
PLoS ONE
PLoS ONE
The RV144 clinical trial of a prime/boost immunizing regimen using recombinant canary pox (ALVAC-HIV) and two gp120 proteins (AIDSVAX B and E) was previously shown to have a 31.2% efficacy rate. Plasma specimens from vaccine and placebo recipients we
Autor:
Constantinos Petrovas, Julie A Ake, Adrian B. McDermott, Adam K. Wheatley, Richard A. Koup, Takuya Yamamoto, Mario Roederer, Eli Boritz, David R. Ambrozak, Kristin L. Boswell, Mark Connors, Sandeep Narpala, Kaska Wloka, Robert Paris, Richard Haubrich, Daniel C. Douek, Jerome H. Kim, Sam Darko
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 10, Iss 1, p e1003853 (2014)
PLoS Pathogens, Vol 10, Iss 1, p e1003853 (2014)
The interaction between follicular T helper cells (TFH) and B cells in the lymph nodes and spleen has a major impact on the development of antigen-specific B cell responses during infection or vaccination. Recent studies described a functional equiva