Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Richard A, Koup"'
Autor:
Shannon Grant, Allan C. deCamp, Chenchen Yu, Susan Buchbinder, Edith Swann, Guido Ferrari, Barney S. Graham, Lindsay N. Carpp, Richard A. Koup, Shelly Karuna, Nicole Frahm, Holly Janes, Ian Frank, Mark J. Mulligan, Youyi Fong, Kelly E. Seaton, Robert T. Bailer, Xiaoying Shen, Barton F. Haynes, Georgia D. Tomaras, Magda Sobieszczyk, Richard M. Novak, M. Juliana McElrath, Vicki C Ashley, Michael C. Keefer, Spyros A. Kalams, Edwin DeJesus, David C. Montefiori, Aaron Deal, Peter B. Gilbert, Marcella Sarzotti-Kelsoe, Scott M. Hammer
Publikováno v:
The Journal of Infectious Diseases
Background HVTN 505 was a human immunodeficiency virus type 1 (HIV-1) preventive vaccine efficacy trial of a DNA/recombinant adenovirus serotype 5 (rAd5) vaccine regimen. We assessed antibody responses measured 1 month after final vaccination (month
Autor:
Patrick Younan, Mathieu Iampietro, Andrew Nishida, Palaniappan Ramanathan, Rodrigo I. Santos, Mukta Dutta, Ndongala Michel Lubaki, Richard A. Koup, Michael G. Katze, Alexander Bukreyev, John T. Patton
Publikováno v:
mBio
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e00845-17 (2017)
Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific activatio
Autor:
John R. Mascola, Srinivas S. Rao, Takuya Yamamoto, Ulrich Baxa, Barney S. Graham, John Paul Todd, Jeffrey I. Cohen, Richard A. Koup, Michael G. Rossmann, Adrian B. McDermott, Gary J. Nabel, Geng Meng, M. Gordon Joyce, Wei Bu, Masaru Kanekiyo, James R R Whittle, Sandeep Narpala
Publikováno v:
Cell
SummaryEpstein-Barr virus (EBV) represents a major global health problem. Though it is associated with infectious mononucleosis and ∼200,000 cancers annually worldwide, a vaccine is not available. The major target of immunity is EBV glycoprotein 35
Autor:
Jason F. Okulicz, Constantinos Petrovas, Brian K. Agan, Richard A. Koup, Robert Paris, Anu Ganesan, Lucimar G. Milagres, Eirini Moysi
Publikováno v:
Pathogens and Immunity, Vol 2, Iss 1, Pp 66-88 (2017)
Background: Why HIV-infected individuals have poor responses to standard dose and schedule hepatitis B virus immunization is not well understood.Methods: We compared the serologic and cellular immune profiles of treated HIV-infected individuals with
Autor:
John R. Mascola, Barney S. Graham, Peter B. Gilbert, Hong Zhao, Steven Lepore, M. Juliana McElrath, Michal Juraska, Jerome H. Kim, Morgane Rolland, Allan C. deCamp, Hongjun Bai, James I. Mullins, Robert T. Bailer, Robert J. O'Connell, Breana Hall, Sodsai Tovanabutra, Richard A. Koup, Shelly Karuna, Annemarie O'Sullivan, Elizabeth Adams, Shana Miller, Daniel E. Geraghty, Eric Sanders-Buell, Hasan Ahmed, Craig A. Magaret, Lindsay N. Carpp, Kalpana Dommaraju, Mario Roederer, Scott M. Hammer, Lawrence Corey, Kultida Poltavee, Raphael Gottardo, Matthew Zirui Tay, Andrew Fiore-Gartland, Nelson L. Michael, Derrick Goodman, Kim G. Wong, Patricia D'Souza, Magdalena E. Sobieszczyk, Lisa M. Frenkel, Paul T. Edlefsen, Meera Bose, Sheila Styrchak, Georgia D. Tomaras, Lennie Chen, Merlin L. Robb, Nicole Frahm, James G. Kublin
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0185959 (2017)
PLoS ONE
PLoS ONE
Although the HVTN 505 DNA/recombinant adenovirus type 5 vector HIV-1 vaccine trial showed no overall efficacy, analysis of breakthrough HIV-1 sequences in participants can help determine whether vaccine-induced immune responses impacted viruses that
Autor:
S. Munir Alam, Guido Ferrari, Thomas N. Denny, Stephen D. Schmidt, Mark K. Louder, Brandy M. Ward, Norman L. Letvin, Hugh C. Welles, Rosemarie D. Mason, Ling Shen, Celia C. LaBranche, Raphael Gottardo, Kathryn E. Foulds, Kelly E. Seaton, Martha Nason, Robert T. Bailer, Robert A. Seder, Will Fischer, Linh Mach, Mario Roederer, John R. Mascola, Georgia D. Tomaras, Bette T. Korber, Srinivas S. Rao, John Paul Todd, Brandon F. Keele, Adam P. Buzby, Gary J. Nabel, Richard A. Koup, Zhi-Yong Yang, David C. Montefiori, Wenjuan Gu
Publikováno v:
Nature
A major challenge for the development of a highly effective AIDS vaccine is the identification of mechanisms of protective immunity. To address this question, we used a nonhuman primate challenge model with simian immunodeficiency virus (SIV). We sho
Autor:
Katie Ewer, Tommy Rampling, Navin Venkatraman, Georgina Bowyer, Danny Wright, Teresa Lambe, Egeruan B. Imoukhuede, Ruth Payne, Sarah Katharina Fehling, Thomas Strecker, Nadine Biedenkopf, Verena Krähling, Claire M. Tully, Nick J. Edwards., Emma M. Bentley, Dhanraj Samuel, Geneviève Labbé, Jing Jin, Malick Gibani., Alice Minhinnic, Morven Wilkie, Ian Poulton, Natalie Lella, Rachel Roberts, Felicity Hartnell, Carly Bliss, Kailan Sierra-Davidson, Jonathan Powlson, Eleanor Berrie, Richard Tedder, B. Chir., Francois Roman, Iris De Ryck, Alfredo Nicosia, Nancy J. Sullivan, Daphne A. Stanley, Olivier T. Mbaya, Julie E. Ledgerwood, Richard M. Schwartz, Loredana Siani, Stefano Colloca, Antonella Folgori, Stefania Di Marco, Riccardo Cortese, Edward Wright, Stephan Becker, Barney S. Graham, Richard A. Koup, Myron M. Levine, Ariane Volkmann, Paul Chaplin, Andrew J. Pollard, Simon J. Draper, D. Phil., W. Ripley Ballou, Alison Lawrie, Sarah C. Gilbert, and Adrian V. S. Hill
BACKGROUND\ud The West African outbreak of Ebola virus disease that peaked in 2014 has caused more than 11,000 deaths. The development of an effective Ebola vaccine is a priority for control of a future outbreak.\ud \ud METHODS\ud In this phase 1 stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180dc9091c76e4ca78fdb439784cfb18
https://westminsterresearch.westminster.ac.uk/download/73fc5235cecfad936d01e4885891d2bdbd8509ccc9118034132a348b6eac7ac2/444979/nejmoa1411627.pdf
https://westminsterresearch.westminster.ac.uk/download/73fc5235cecfad936d01e4885891d2bdbd8509ccc9118034132a348b6eac7ac2/444979/nejmoa1411627.pdf
Autor:
Brigitte Autran, Rémi Cheynier, Yin Xu, Adrien Six, Arnaud Moris, Angeline Rouers, Lucie Colineau, Assia Samri, Alejandra Urrutia, Takuya Yamamoto, Anthony D. Kelleher, Stéphanie Graff-Dubois, Richard A. Koup, Sylvain Cardinaud, Karim Dorgham, Pierre-Grégoire Coulon, Anne Hosmalin, Eric Oksenhendler, John Zaunders, Hang-Phuong Pham
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, Vol 10, Iss 10, p e0140978 (2015)
PLoS ONE, Public Library of Science, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, 2015, 10 (10), pp.e0140978. ⟨10.1371/journal.pone.0140978⟩
PLoS ONE, Vol 10, Iss 10, p e0140978 (2015)
International audience; Follicular helper T (Tfh) cells within secondary lymphoid organs control multiple steps of B cell maturation and antibody (Ab) production. HIV-1 infection is associated with an altered B cell differentiation and Tfh isolated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b99955d4a70eff404e532fbe2a1260
https://www.hal.inserm.fr/inserm-01222249/file/journal.pone.0140978.pdf
https://www.hal.inserm.fr/inserm-01222249/file/journal.pone.0140978.pdf
Autor:
Ndongala Michel Lubaki, Patrick Younan, Rodrigo I Santos, Michelle Meyer, Mathieu Iampietro, Richard A Koup, Alexander Bukreyev
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006031 (2016)
PLoS Pathogens
PLoS Pathogens
Ebola virus (EBOV) infections are characterized by deficient T-lymphocyte responses, T-lymphocyte apoptosis and lymphopenia. We previously showed that disabling of interferon-inhibiting domains (IIDs) in the VP24 and VP35 proteins effectively unblock
Autor:
Michael R. Betts, Stephen I. Pelton, Bruce D. Walker, Philip J. R. Goulder, Ross E. McKinney, Marcus Altfeld, Eric S. Rosenberg, Ken Annamalai, Yanhua Tang, Alicja Trocha, Spyros A. Kalams, Sandra K. Burchett, Suqin He, Richard A. Koup, Kenneth H. Mayer, Christian Brander, Christopher A. O’Callaghan, Graham S. Ogg, Kenneth McIntosh
Publikováno v:
The Journal of Experimental Medicine
The highly sensitive quantitation of virus-specific CD8+ T cells using major histocompatibility complex–peptide tetramer assays has revealed higher levels of cytotoxic T lymphocytes (CTLs) in acute and chronic virus infections than were recognized