Zobrazeno 1 - 2
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pro vyhledávání: '"Geethu E. Thomas"'
Autor:
Zachary Blatman, Rose Hurren, Neil MacLean, Ahmed Aman, Taira Kiyota, Kazem Nouri, Rima Al-awar, Moustafa Abohawya, Mehakpreet Saini, Karen Arevalo, Samir H. Barghout, Aaron D. Schimmer, Troy Ketela, Geethu E. Thomas
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight
JCI Insight
TAK-243 is a first-in-class inhibitor of ubiquitin-like modifier activating enzyme 1 that catalyzes ubiquitin activation, the first step in the ubiquitylation cascade. Based on its preclinical efficacy and tolerability, TAK-243 has been advanced to p
Autor:
Geethu E. Thomas, Ayesh K. Seneviratne, Rose Hurren, Neil MacLean, Aaron D. Schimmer, Rashim Pal Singh
Publikováno v:
STAR Protocols
STAR Protocols, Vol 1, Iss 3, Pp 100163-(2020)
STAR Protocols, Vol 1, Iss 3, Pp 100163-(2020)
Summary We describe a method to silence genes in primary acute myeloid leukemia cells by transducing them with shRNA in lentiviral vectors. The transduction of primary non-adherent cells is particularly challenging. The protocol will aid in performin