Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Ingemar Björkhem"'
Autor:
Anna Sandebring-Matton, Julen Goikolea, Ingemar Björkhem, Laura Paternain, Nina Kemppainen, Tiina Laatikainen, Tiia Ngandu, Juha Rinne, Hilkka Soininen, Angel Cedazo-Minguez, Alina Solomon, Miia Kivipelto
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract Background 27-Hydroxycholesterol (27-OH), the main circulating oxysterol in humans and the potential missing link between peripheral hypercholesterolemia and Alzheimer’s disease (AD), has not been investigated previously in relation to cog
Externí odkaz:
https://doaj.org/article/331e6ffc2e9744dcabc5a657dfe423ad
Autor:
Emanuele Porru, Erik Edström, Lisa Arvidsson, Adrian Elmi-Terander, Alexander Fletcher-Sandersjöö, Anita Lövgren Sandblom, Magnus Hansson, Frida Duell, Ingemar Björkhem
Publikováno v:
Brain Sciences, Vol 12, Iss 11, p 1450 (2022)
Idiopathic normal pressure hydrocephalus (iNPH) is the most common form of hydrocephalus in the adult population, and is often treated with cerebrospinal fluid (CSF) drainage using a ventriculoperitoneal (VP) shunt. Symptoms of iNPH include gait impa
Externí odkaz:
https://doaj.org/article/61c367d9fb9949ba8ba68eaec67e7e71
Autor:
Ahmed Saeed, Federico Floris, Ulla Andersson, Irina Pikuleva, Anita Lövgren-Sandblom, Maria Bjerke, Martin Paucar, Anders Wallin, Per Svenningsson, Ingemar Björkhem
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 2, Pp 313-318 (2014)
There is a continuous flux of the oxysterol 27-hydroxycholesterol (27-OHC) from the circulation across the blood-brain barrier (BBB) into the brain. The major metabolite of 27-OHC in the brain is 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA). We con
Externí odkaz:
https://doaj.org/article/59a7314806d24d4a9fc206a8a02a6f57
Autor:
Zeina Ali, Maura Heverin, Maria Olin, Jure Acimovic, Anita Lövgren-Sandblom, Marjan Shafaati, Ann Båvner, Vardiella Meiner, Eran Leitersdorf, Ingemar Björkhem
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 4, Pp 1033-1043 (2013)
The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro. Their role as physiological regulators under in vivo conditions is
Externí odkaz:
https://doaj.org/article/3b238914b2e3482080eebfdfe6ed5a09
Autor:
Rebecca Schüle, Teepu Siddique, Han-Xiang Deng, Yi Yang, Sandra Donkervoort, Magnus Hansson, Ricardo E. Madrid, Nailah Siddique, Ludger Schöls, Ingemar Björkhem
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 819-823 (2010)
Patients with a recessively inherited “pure” hereditary spastic paresis (SPG5) have mutations in the gene coding for the oxysterol 7 α hydroxylase (CYP7B1). One of the expected metabolic consequences of such mutations is accumulation of oxystero
Externí odkaz:
https://doaj.org/article/300106a2af6740e5ab5d485950716129
Autor:
Steve Meaney, Maura Heverin, Ute Panzenboeck, Lena Ekström, Magnus Axelsson, Ulla Andersson, Ulf Diczfalusy, Irina Pikuleva, John Wahren, Wolfgang Sattler, Ingemar Björkhem
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 4, Pp 944-951 (2007)
Recently, we demonstrated a net blood-to-brain passage of the oxysterol 27-hydroxycholesterol corresponding to 4–5 mg/day. As the steady-state levels of this sterol are only 1–2 μg/g brain tissue, we hypothesized that it is metabolized and subse
Externí odkaz:
https://doaj.org/article/29855b943bef4c258274a21859ee3155
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 4, Pp 793-799 (2003)
The side chain oxidized oxysterol 24S-hydroxycholesterol (24-OH-chol) is formed almost exclusively in the brain, and there is a continuous passage of this oxysterol through the circulation to the liver. 27-Hydroxycholesterol (27-OH-chol) is produced
Externí odkaz:
https://doaj.org/article/fa6ec99c0a8c46fa8b2d49b6ba011426
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 12, Pp 2130-2135 (2002)
Oxysterols possess powerful biological activities. Some of their effects on the regulation of key enzymes are similar to those of cholesterol, but are much more potent. One of the critical properties of oxysterols is their ability to pass lipophilic
Externí odkaz:
https://doaj.org/article/e9ca9175657c495499984a61d83ba249
Autor:
Amir Babiker, Olof Andersson, Dan Lindblom, Jan van der Linden, Björn Wiklund, Dieter Lütjohann, Ulf Diczfalusy, Ingemar Björkhem
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 8, Pp 1417-1425 (1999)
Human alveolar macrophages have exceptionally high capacity to convert cholesterol into 27-hydroxycholesterol and cholestenoic acid by the sterol 27-hydroxylase mechanism. It is shown here that the human lung has a higher content of 27-hydroxycholest
Externí odkaz:
https://doaj.org/article/1dcb8a31f600412fae14c766c6728997
Autor:
Angel Cedazo-Minguez, Nina Kemppainen, Ingemar Björkhem, Juha O. Rinne, Miia Kivipelto, Hilkka Soininen, Alina Solomon, Tiina Laatikainen, Julen Goikolea, Laura Paternain, Anna Sandebring-Matton, Tiia Ngandu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background 27-Hydroxycholesterol (27-OH), the main circulating oxysterol in humans and the potential missing link between peripheral hypercholesterolemia and Alzheimer’s disease (AD), has not been investigated previously in relation to cognition an