Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Thomas Tuschl"'
Autor:
Jina Nanayakkara, Kathrin Tyryshkin, Parvin Mousavi, Blake Pyman, Thomas Tuschl, Emily Kaczmarek, Neil Renwick
Publikováno v:
The American Journal of Pathology. 192:344-352
Next-generation sequencing has enabled the collection of large biological data sets, allowing novel molecular-based classification methods to be developed for increased understanding of disease. miRNAs are small regulatory RNA molecules that can be q
Autor:
Thomas Tuschl, Li-Xuan Qin, Jiejun Shi, Jian Zou, Ann Lee, Samuel Singer, Aleksandra Mihailovic, Thalia A. Farazi
Publikováno v:
JCO Clinical Cancer Informatics
PURPOSE Methods for depth normalization have been assessed primarily with simulated data or cell-line–mixture data. There is a pressing need for benchmark data enabling a more realistic and objective assessment, especially in the context of small R
Autor:
Thomas Tuschl, Kemal M. Akat, John H. Lockhart, Ying Yang, Ezinne Francess Mong, Jeffrey VanWye, Charles J. Lockwood, Hana Totary-Jain, Frederick Schatz, John C.M. Tsibris, John Canfield, Umit A. Kayisli
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
During implantation, cytotrophoblasts undergo epithelial-to-mesenchymal transition (EMT) as they differentiate into invasive extravillous trophoblasts (EVTs). The primate-specific microRNA cluster on chromosome 19 (C19MC) is exclusively expressed in
Autor:
Anna Thrun, Annarita Patrizi, Charles S. Umbaugh, Teresa Dallinger, Sylvia Kreger, Pratik R. Patil, Claudio A. P. Joazeiro, Jia Liu, Gregory A. Cox, Yu Kigoshi-Tansho, Aitor Garzia, Thomas Tuschl
Publikováno v:
Mol Cell
Summary Incompletely synthesized nascent chains obstructing large ribosomal subunits are targeted for degradation by ribosome-associated quality control (RQC). In bacterial RQC, RqcH marks the nascent chains with C-terminal alanine (Ala) tails that a
Autor:
Saumya Das, K. Mark Ansel, Markus Bitzer, Xandra O. Breakefield, Alain Charest, David J. Galas, Mark B. Gerstein, Mihir Gupta, Aleksandar Milosavljevic, Michael T. McManus, Tushar Patel, Robert L. Raffai, Joel Rozowsky, Matthew E. Roth, Julie A. Saugstad, Kendall Van Keuren-Jensen, Alissa M. Weaver, Louise C. Laurent, Asim B. Abdel-Mageed, Catherine Adamidi, P. David Adelson, Kemal M. Akat, Eric Alsop, Jorge Arango, Neil Aronin, Seda Kilinc Avsaroglu, Azadeh Azizian, Leonora Balaj, Iddo Z. Ben-Dov, Karl Bertram, Robert Blelloch, Kimberly A. Bogardus, Xandra Owens Breakefield, George A. Calin, Bob S. Carter, Al Charest, Clark C. Chen, Tanuja Chitnis, Robert J. Coffey, Amanda Courtright-Lim, Amrita Datta, Peter DeHoff, Thomas G. Diacovo, David J. Erle, Alton Etheridge, Marc Ferrer, Jeffrey L. Franklin, Jane E. Freedman, Timur Galeev, Roopali Gandhi, Aitor Garcia, Mark Bender Gerstein, Vikas Ghai, Ionita Calin Ghiran, Maria D. Giraldez, Andrei Goga, Tasos Gogakos, Beatrice Goilav, Stephen J. Gould, Peixuan Guo, Fred Hochberg, Bo Huang, Matt Huentelman, Craig Hunter, Elizabeth Hutchins, Andrew R. Jackson, M. Yashar S. Kalani, Pinar Kanlikilicer, Reka Agnes Karaszti, Anastasia Khvorova, Yong Kim, Hogyoung Kim, Taek Kyun Kim, Robert Kitchen, Richard P. Kraig, Anna M. Krichevsky, Raymond Y. Kwong, Minyoung Lee, Noelle L’Etoile, Shawn E. Levy, Feng Li, Jenny Li, Xin Li, Gabriel Lopez-Berestein, Rocco Lucero, Bogdan Mateescu, A.C. Matin, Klaas E.A. Max, Thorsten R. Mempel, Cindy Meyer, Debasis Mondal, Kenneth Jay Mukamal, Oscar D. Murillo, Thangamani Muthukumar, Deborah A. Nickerson, Christopher J. O’Donnell, Dinshaw J. Patel, James G. Patton, Anu Paul, Elaine R. Peskind, Mitch A. Phelps, Chaim Putterman, Peter J. Quesenberry, Joseph F. Quinn, Saritha Ranabothu, Shannon Jiang Rao, Cristian Rodriguez-Aguayo, Anthony Rosenzweig, Marc S. Sabatine, Nikita A. Sakhanenko, Julie Anne Saugstad, Thomas D. Schmittgen, Neethu Shah, Ravi Shah, Kerby Shedden, Jian Shi, Anil K. Sood, Anuoluwapo Sopeyin, Ryan M. Spengler, Robert Spetzler, Srimeenakshi Srinivasan, Sai Lakshmi Subramanian, Manikkam Suthanthiran, Kahraman Tanriverdi, Yun Teng, Muneesh Tewari, William Thistlethwaite, Thomas Tuschl, Karolina Kaczor Urbanowicz, Kasey C. Vickers, Olivier Voinnet, Kai Wang, Zhiyun Wei, Howard L. Weiner, Zachary R. Weiss, Zev Williams, David T.W. Wong, Prescott G. Woodruff, Xinshu Xiao, Irene K. Yan, Ashish Yeri, Bing Zhang, Huang-Ge Zhang
Publikováno v:
Das, Saumya; Ansel, K Mark; Bitzer, Markus; Breakefield, Xandra O; Charest, Alain; Galas, David J; et al.(2019). The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. Cell, 177(2), 231-242. doi: 10.1016/j.cell.2019.03.023. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/42g411w7
© 2019 Elsevier Inc. The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800e9cd219516f263350ecb4f3aff02d
https://europepmc.org/articles/PMC6601620/
https://europepmc.org/articles/PMC6601620/
Publikováno v:
Molecular Cell. 77:1193-1205.e5
Summary Ribosome-associated quality control (RQC) purges aberrant mRNAs and nascent polypeptides in a multi-step molecular process initiated by the E3 ligase ZNF598 through sensing of ribosomes collided at aberrant mRNAs and monoubiquitination of dis
Autor:
Mengfei Wu, Kamil Slowikowski, Belmont Hm, Ranabathou S, Jay A. Graham, Robert R. Clancy, Mordecai Koenigsberg, Juan P. Rocca, Manjunath Kustagi, Chaim Putterman, Hemant Suryawanshi, Evan Der, Helen Rominieki, Soumya Raychaudhuri, Nicole Bornkamp, Jill P. Buyon, Schulte E, Pavel Morozov, Judith A. James, James Pullman, Jordan N, Michele H. Mokrzycki, Peter M. Izmirly, Beatrice Goilav, Thomas Tuschl, Joel M. Guthridge
Lupus nephritis (LN) occurs in up to 50% of patients with systemic lupus erythematosus (SLE), and is a major contributor to mortality and morbidity. LN presents as a highly heterogeneous disease both in histopathology and response to therapy. The mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9707c0ff90e66dc0c87302c6299d731f
Autor:
Thomas Tuschl, Pu Gao, Thomas Zillinger, Winfried Barchet, Dinshaw J. Patel, Weiyi Wang, Liang Deng, Gunther Hartmann, Manuel Ascano, Peihong Dai
Publikováno v:
Cell reports
Cell Reports, Vol 8, Iss 6, Pp 1668-1676 (2014)
Cell Reports, Vol 8, Iss 6, Pp 1668-1676 (2014)
SUMMARY The drug DMXAA (5,6-dimethylxanthenone-4-acetic acid) showed therapeutic promise against solid tumors in mouse models but subsequently failed in human clinical trials. DMXAA was later discovered to activate mouse, but not human, STING, an ada
Autor:
Brad R. Rosenberg, Thomas Tuschl, F. Nina Papavasiliou, Kenneth Lay, Eric L. Fritz, Aleksandra Mihailovic
Publikováno v:
Nature Immunology. 14:749-755
Additional editing activities for the cytidine deaminase AID beyond immunoglobulin-gene diversification have been proposed. Papavasiliou and colleagues now definitively show that antibody diversification is AID's sole physiological function in activa
Autor:
David L. Corcoran, Thomas Tuschl, Christine Langlois, Jeffrey Nusbaum, Zev Williams, Manuel Ascano, Scott Dewell, Mathias Munschauer, Markus Hafner, Jason B. Miller, Neelanjan Mukherjee, Pradeep Bandaru, Uwe Ohler
Publikováno v:
Nature
Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-orchidism in males and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (