Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Serge Y. Fuchs"'
Publikováno v:
Nucleic Acids Research
Meiotic recombination enables reciprocal exchange of genetic information between parental chromosomes and is essential for fertility. MEIOB, a meiosis-specific ssDNA-binding protein, regulates early meiotic recombination. Here we report that the huma
Autor:
Hemma Murali, Ajeya Nandi, Serge Y. Fuchs, Ratnesh Kumar Srivastava, Sabrina Kim, M. Raza Zaidi, Snahlata Singh, Mario Andres Blanco, Sushil Kumar, Rizwan Saffie, Gatha Thacker, Luca Busino, Mary Baldeon, Rumela Chakrabarti, Satrajit Sinha, John W. Tobias
Publikováno v:
Nat Cell Biol
Triple-negative breast cancer (TNBC) is characterized by a high degree of immune infiltrate in the tumour microenvironment, which may influence the fate of TNBC cells. We reveal that loss of the tumour suppressive transcription factor Elf5 in TNBC ce
Autor:
Frank Chinga, Serge Y. Fuchs, Zoya Ignatova, Jiangbin Ye, Crystal S. Conn, Weixuan Fu, Constantinos Koumenis, Andrew V. Kossenkov, Carlo Salas Salinas, Ioannis I. Verginadis, Nektaria Maria Leli, Ravi K. Amaravadi, Christine Polte, Paul P. Wang, Alexandra M Monroy, Davide Ruggero, J. Alan Diehl, Feven Tameire, Rani Ojha
Publikováno v:
Nature cell biology, vol 21, iss 7
Nature cell biology
Nature cell biology
The c-Myc oncogene drives malignant progression and induces robust anabolic and proliferative programmes leading to intrinsic stress. The mechanisms enabling adaptation to MYC-induced stress are not fully understood. Here we reveal an essential role
Autor:
Nathan Shores, Partha K. Chandra, Lili Bao, Tong Wu, Kyoung-Sub Song, Darren P. Baker, Curt H. Hagedorn, Srikanta Dash, Fatma M. Aboulnasr, William C. Wimley, Shuanghu Liu, Luis A. Balart, Serge Y. Fuchs
Publikováno v:
The American Journal of Pathology. 184(1):214-229
A stable and persistent Hepatitis C virus (HCV) replication cell culture model was developed to examine clearance of viral replication during long-term treatment using interferon-α (IFN-α), IFN-λ, and ribavirin (RBV). Persistently HCV-infected cel
Autor:
Jeffrey A. Hooke, Lynn M. Neilson, Thai H. Tran, Inna Chervoneva, Albert J. Kovatich, Hallgeir Rui, Craig D. Shriver, Chengbao Liu, Boris Freydin, Serge Y. Fuchs, Amy R. Peck, Melanie A. Girondo, Takahiro Sato, Terry Hyslop, Chelain R. Goodman
Publikováno v:
Oncogene
Prolactin controls the development and function of milk-producing breast epithelia but also supports growth and differentiation of breast cancer, especially luminal subtypes. A principal signaling mediator of prolactin, Stat5, promotes cellular diffe
Autor:
Serge Y. Fuchs, Hallgeir Rui, Darren P. Baker, Wei-Chun HuangFu, Anna Lokshin, Chengbao Liu, Juan Qian, Jianghuai Liu
Publikováno v:
Oncogene
Interferon alpha (IFNα) is widely used for treatment of melanoma and certain other malignancies. This cytokine as well as the related IFNβ exerts potent anti-tumorigenic effects; however, their efficacy in patients is often suboptimal. Here, we rep
Autor:
Robert B. Hamanaka, Rafael Aldabe, James P. Casey, Christina Grigoriadou, Wei Chun HuangFu, J. Alan Diehl, Serge Y. Fuchs, K.G. Suresh Kumar, Juan Qian, Jianghuai Liu
Publikováno v:
Cell Host & Microbe. 5:72-83
SummaryPhosphorylation-dependent ubiquitination and degradation of the IFNAR1 chain of the type I interferon (IFN) receptor is regulated by two different pathways, one of which is ligand independent. We report that this ligand-independent pathway is
Autor:
Serge Y. Fuchs, Stuart J. Frank
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1782:785-794
Growth hormone plays an important role in regulating numerous functions in vertebrates. Several pathways that negatively regulate the magnitude and duration of its signaling (including expression of tyrosine phosphatases, SOCS and PIAS proteins) are
Autor:
Serge Y. Fuchs, Jeffrey Patterson-Fortin, Roger A. Greenberg, Junmin Wu, Christopher J. Carbone, Bernadette Aressy, Sabyasachi Bhattacharya, Vibhor Gupta, Bentley Varghese, Kanstantsin V. Katlinski, Hui Zheng
Publikováno v:
Cell Reports, Vol 5, Iss 1, Pp 180-193 (2013)
SummaryLysine63-linked ubiquitin (K63-Ub) chains represent a particular ubiquitin topology that mediates proteasome-independent signaling events. The deubiquitinating enzyme (DUB) BRCC36 segregates into distinct nuclear and cytoplasmic complexes that
Autor:
K.G. Suresh Kumar, Bentley Varghese, Stefan N. Constantinescu, Serge Y. Fuchs, Sandra Pellegrini, Darren P. Baker, Anamika Banerjee
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 283 (27), pp.18566-72. ⟨10.1074/jbc.M800991200⟩
Journal of Biological Chemistry, 2008, 283 (27), pp.18566-72. ⟨10.1074/jbc.M800991200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 283 (27), pp.18566-72. ⟨10.1074/jbc.M800991200⟩
Journal of Biological Chemistry, 2008, 283 (27), pp.18566-72. ⟨10.1074/jbc.M800991200⟩
International audience; Linear endocytic motifs of signaling receptors as well as their ubiquitination determine the rate of ligand-induced endocytosis that mediates down-regulation of these receptors and restricts the magnitude and duration of their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3794a7f107868f74c531c1231d0ad47e
https://europepmc.org/articles/PMC2441555/
https://europepmc.org/articles/PMC2441555/