Zobrazeno 1 - 7
of 7
pro vyhledávání: '"R. Simeonov"'
Autor:
Bin Zhang, Ian A. Vogel, Zhaolin Sun, Eric Shifrut, Siqi Chen, Igal Ifergan, Grace Y. Prator, Yana Zhang, Youjin V. Lee, Oren Shaked, Frédéric Van Gool, Zhongmei Li, Jessica T. Cortez, Yuanming Xu, Jeffrey A. Bluestone, Dimitre R. Simeonov, Theodore L. Roth, Elena Montauti, Deyu Fang, Y Zhang, Alexander Marson
Regulatory T cells (Tregs) are required to control immune responses and maintain homeostasis but are a significant barrier to anti-tumor immunity1. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852ebc7166052cd61655467b8118b2f5
Autor:
Marijke P. Baltissen, Susan Zwakenberg, Alexander Marson, Michiel Vermeulen, Suchandrima Banerjee, Dimitre R. Simeonov, Matthijs J. D. Baars, Thera Douma, S. de Roock, Darienne R. Myers, Yvonne Vercoulen, Jeroen P. Roose, F van Wijk, Kayla Kulhanek
RasGRP1 is a Ras guanine nucleotide exchange factor, and an essential regulator of lymphocyte receptor signaling. In mice, Rasgrp1 deletion results in defective T lymphocyte development. RASGRP1-deficient patients suffer from immune deficiency, and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37eba3e5d5843e829aee5ebb8d3a088e
Autor:
Andrew May, Youjin V. Lee, Alyssa C. Indart, Jessica T. Cortez, Zhongmei Li, Alice Y. Chan, Jonathan M. Woo, James R. Lupski, Mark S. Anderson, Theodore L. Roth, Claudia M.B. Carvalho, Dimitre R. Simeonov, Alexander Marson, Daniel S. Rokhsar, F. William Buaas, James Zou, Alexander J. Brandt
Publikováno v:
Communications Biology
Communications biology, vol 2, iss 1
Communications Biology, Vol 2, Iss 1, Pp 1-6 (2019)
Communications biology, vol 2, iss 1
Communications Biology, Vol 2, Iss 1, Pp 1-6 (2019)
A persistent concern with CRISPR-Cas9 gene editing has been the potential to generate mutations at off-target genomic sites. While CRISPR-engineering mice to delete a ~360 bp intronic enhancer, here we discovered a founder line that had marked immune
Autor:
Howard Y. Chang, Chao Dai, Evan A. Boyle, Jeffrey M. Granja, Paul A. Khavari, Nabeela Suliman, Michelle L.T. Nguyen, Alexander Marson, Adam J. Rubin, Peyton Greenside, Jin Xu, Thomas Quertermous, Josh Tycko, Anshul Kundaje, M. Ryan Corces, Yuning Wei, Katelynn R. Kazane, Seung Woo Cho, William J. Greenleaf, Dimitre R. Simeonov, Ryan A. Flynn, Ansuman T. Satpathy, Maxwell R. Mumbach, Jacob E. Corn, Benjamin G. Gowen, Rui Li, Trieu Nguyen
The challenge of linking intergenic mutations to target genes has limited molecular understanding of human diseases. Here, we show that H3K27ac HiChIP generates high-resolution contact maps of active enhancers and target genes in rare primary human T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67a0ff11f561ccccec4826ffc0e5a1b
Autor:
Eric Boyer, Mandy Boontanrart, Mark J. Daly, Alice Y. Chan, Nicolas Bray, Theodore L. Roth, Frédéric Van Gool, Jonathan M. Woo, Dimitre R. Simeonov, Mark S. Anderson, Kyle K. Fahr, Gemma L. Curie, Therese Mitros, Jacob E. Corn, Alexander Marson, Meena Subramaniam, Nicki Naddaf, Kathrin Schumann, Chun J Ye, Jeffrey A. Bluestone, Youjin Lee, Graham J. Ray, Michelle L.T. Nguyen, Rachel E. Gate, Benjamin G. Gowen
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell type-specific transcriptional programs and responses to specific extracellular cues 1-3. In order to understand the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84102731d84f9b2378905cebb472b51e
Autor:
Nicholas D. Cardillo, Dimitre R. Simeonov, Carmelo Carmona-Rivera, William A. Gahl, Carmen L. Cadilla
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1833(3):468-478
Hermansky–Pudlak syndrome (HPS) is a group of rare autosomal recessive disorders characterized by oculocutaneous albinism, a bleeding tendency, and sporadic pulmonary fibrosis, granulomatous colitis or infections. Nine HPS-causing genes have been i
Autor:
Chaoxing Yang, Dimitre R. Simeonov, David T. Corr, Douglas M. Swank, Ryan A. Koppes, Catherine C. Eldred
Publikováno v:
Biophysical Journal. (7):1218-1226
Transgenic Drosophila are highly useful for structure-function studies of muscle proteins. However, our ability to mechanically analyze transgenically expressed mutant proteins in Drosophila muscles has been limited to the skinned indirect flight mus