Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mitsuhiko Ikura"'
Autor:
Ming Li, Quan Li, Ni Liu, Frances A. Shepherd, Teklab Gebregiworgis, Ming-Sound Tsao, Nadeem Moghal, Nhu-An Pham, Mitsuhiko Ikura, Ningdi Feng Liu, Zhenhao Fang, Hirotsugu Notsuda, Ku-Geng Huo, Christopher B. Marshall
Publikováno v:
Journal of Thoracic Oncology. 17:277-288
Introduction Mutations in BRAF occur in 2-4% of lung adenocarcinoma (LUAD) patients. Combination dabrafenib/trametinib or single-agent vemurafenib is approved only for patients with cancers driven by the V600E BRAF mutation. Targeted therapy is not c
Autor:
Mitsuhiko Ikura, Teklab Gebregiworgis, Christopher B. Marshall, Ki-Young Lee, Geneviève M.C. Gasmi-Seabrook, Masahiro Enomoto
Publikováno v:
Chemical Science
KRAS forms transient dimers and higher-order multimers (nanoclusters) on the plasma membrane, which drive MAPK signaling and cell proliferation. KRAS is a frequently mutated oncogene, and while it is well known that the most prevalent mutation, G12D,
Autor:
Mitsuhiko Ikura, Zhenhao Fang, Shohei Koide, Geneviève M.C. Gasmi-Seabrook, Masahiro Enomoto, Christopher B. Marshall, Ki-Young Lee, Le Zheng
Publikováno v:
Angew Chem Int Ed Engl
KRAS homo-dimerization has been implicated in the activation of RAF kinases, however, the mechanism and structural basis remain elusive. We developed a system to study KRAS dimerization on nanodiscs using paramagnetic relaxation enhancement (PRE) NMR
Autor:
Etienne Coyaud, Mitsuhiko Ikura, Arun A. Chandrakumar, Robert Rottapel, Brian Raught, Christopher B. Marshall
Publikováno v:
Journal of Cell Biology
Journal of Cell Biology, 2021, Journal of Cell Biology, 220 (7), pp.e202008037. ⟨10.1083/jcb.202008037⟩
The Journal of Cell Biology
Journal of Cell Biology, 2021, Journal of Cell Biology, 220 (7), pp.e202008037. ⟨10.1083/jcb.202008037⟩
The Journal of Cell Biology
Chandrakumar et al. reveal that lumen formation in epithelial cells is regulated by ADP-ribosylation and ubiquitylation. Tankyrase inhibits its substrates SH3BP5 and SH3BP5L, which are Rab11a guanine nucleotide exchange factors, while the E3 ligase R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762381027868e558461dfc23c3863dba
http://hdl.handle.net/20.500.12210/75051
http://hdl.handle.net/20.500.12210/75051
Autor:
Thierry Capiod, Emmanuelle Masson, Wesley H. Brooks, Reginald Philippe, Nicolas Lebonvallet, Wayne C. Guida, Pauline Dubar, Miguel Burgos, Juan Llopis, Fabrice Antigny, Olivier Mignen, Peter B. Stathopulos, Claude Férec, Mitsuhiko Ikura, Maud Frieden, F. Campeotto, Beatriz Domingo, Sreya Mukherjee, Cédric Le Maréchal, Paul Buscaglia, Jian-Min Chen
Publikováno v:
Journal of Cell Science, Vol. 134, No 3 (2021)
Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2021, 134 (3), ⟨10.1242/jcs.244012⟩
Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2021, 134 (3), ⟨10.1242/jcs.244012⟩
Since deregulation of intracellular Ca2+ can lead to intracellular trypsin activation, and stromal interaction molecule-1 (STIM1) protein is the main regulator of Ca2+ homeostasis in pancreatic acinar cells, we explored the Ca2+ signaling in 37 STIM1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb375b757ccf1fc81d2061d83a917b5
https://archive-ouverte.unige.ch/unige:151400
https://archive-ouverte.unige.ch/unige:151400
Autor:
Le Zheng, Geneviève M.C. Gasmi-Seabrook, Mitsuhiko Ikura, Zhenhao Fang, Ku-Geng Huo, Christopher B. Marshall, Ming-Sound Tsao, Ki-Young Lee, Nadeem Moghal
Publikováno v:
Proc Natl Acad Sci U S A
Membrane anchoring of farnesylated KRAS is critical for activation of RAF kinases, yet our understanding of how these proteins interact on the membrane is limited to isolated domains. The RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF
Autor:
M. Enomoto, Ki-Young Lee, Sung-In Back, Benjamin M M Grant, Teklab Gebregiworgis, Christopher B. Marshall, Mitsuhiko Ikura, Noboru Ishiyama
Publikováno v:
Science Signaling. 13
KRAS4b is a small guanosine triphosphatase (GTPase) protein that regulates several signal transduction pathways that underlie cell proliferation, differentiation, and survival. KRAS4b function requires prenylation of its C terminus and recruitment to
Autor:
Wesley H. Brooks, Juan Llopis, Olivier Mignen, Mitsuhiko Ikura, Fabrice Antigny, Emmanuelle Masson, Paul Buscaglia, Reginald Philippe, Sreya Mukherjee, F. Campeotto, Cédric Le Maréchal, Maud Frieden, Beatriz Domingo, Jian-Min Chen, Nicolas Lebonvallet, Wayne C. Guida, Peter B. Stathopulos, Claude Férec, Thierry Capiod, Pauline Dubar, Miguel Burgos
Since deregulation of intracellular Ca2+ can lead to intracellular trypsin activation and STIM1 (stromal interaction molecule-1) protein is the main regulator of Ca2+ homeostasis in pancreatic acinar cells, we explored the Ca2+ signaling in 37 STIM1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db78d98eec1a116b093c8cc20e9b8e9
https://doi.org/10.1101/2020.01.22.916254
https://doi.org/10.1101/2020.01.22.916254
Autor:
Noboru Ishiyama, Le Zheng, Peter B. Stathopulos, Sung-In Back, Masahiro Enomoto, Tadateru Nishikawa, Mitsuhiko Ikura
Publikováno v:
Journal of molecular biology. 432(2)
Store operated calcium (Ca2+) entry (SOCE) is the process whereby endoplasmic reticulum (ER) Ca2+ store depletion causes Orai1-composed Ca2+ channels on the plasma membrane (PM) to open, mediating a rise in cytosolic Ca2+ levels. Stromal interaction
Publikováno v:
Methods in Molecular Biology ISBN: 9781493990290
Calmodulin (CaM) is a ubiquitous calcium-sensing protein that has one of the most highly conserved sequences among eukaryotes. CaM has been a useful tool for biologists studying calcium signaling for decades. In recent years, CaM has also been implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a75693135abf91723d8fa9f4567f73eb
https://doi.org/10.1007/978-1-4939-9030-6_13
https://doi.org/10.1007/978-1-4939-9030-6_13