Zobrazeno 1 - 2
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pro vyhledávání: '"Michael Cerniglia"'
Autor:
Earl Avramis, Charles Ng, Michael Cerniglia, Helena Escuin-Ordinas, Amanda Lassen, Bjoern Titz, Begonya Comin-Anduix, Mohammad Atefi, Thomas G. Graeber, Antoni Ribas, Deborah J.L. Wong, David Foulad
Publikováno v:
Molecular cancer, vol 14, iss 1
Molecular Cancer
Molecular Cancer
Background Approximately 20% of melanomas contain a mutation in NRAS. However no direct inhibitor of NRAS is available. One of the main signaling pathways downstream of NRAS is the MAPK pathway. In this study we investigated the possibility of blocki
Autor:
Lidia Robert, Antoni Ribas, Jennifer Tsoi, David Foulad, Michael Cerniglia, Begonya Comin-Anduix, Roger S. Lo, Amanda Lassen, Earl Avramis, Geetha Avarappatt, Thomas G. Graeber, Mohammad Atefi, Ahmed A. Samatar, Deborah J.L. Wong
Publikováno v:
Molecular Cancer
Background In melanoma, dysregulation of the MAPK pathway, usually via BRAFV600 or NRASQ61 somatic mutations, leads to constitutive ERK signaling. While BRAF inhibitors are initially effective for BRAF-mutant melanoma, no FDA-approved targeted therap