Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mengfan Tang"'
Publikováno v:
DNA Repair (Amst)
Genome integrity is constantly challenged by various DNA lesions with DNA double-strand breaks (DSBs) as the most cytotoxic lesions. In order to faithfully repair DSBs, DNA damage response (DDR) signaling networks have evolved, which organize many mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca829b9a47863251a0bc826980caf735
https://europepmc.org/articles/PMC8207832/
https://europepmc.org/articles/PMC8207832/
Autor:
Chao Wang, Mengfan Tang, Xu Feng, Nan Li, Namsoo Lee, Fan Yao, Dan Su, Junjie Chen, Litong Nie
Publikováno v:
Mol Cell Proteomics
Specific E3 ligases target tumor suppressors for degradation. Inhibition of such E3 ligases may be an important approach to cancer treatment. RNF146 is a RING domain and PARylation-dependent E3 ligase that functions as an activator of the β-catenin/
Autor:
Zhen Chen, Chao Wang, Anthony T. Tubbs, Dadi Jiang, Min Huang, Junjie Chen, Huimin Zhang, Litong Nie, Dan Su, Xu Feng, Sriram Sridharan, André Nussenzweig, Chunchao Zhang, Mengfan Tang, Yun Xiong
Publikováno v:
EMBO J
Mechanistic understanding of how ionizing radiation induces type I interferon signaling and how to amplify this signaling module should help to maximize the efficacy of radiotherapy. In the current study, we report that inhibitors of the DNA damage r
Autor:
Litong Nie, Xi Shen, Chao Wang, Mrinal Srivastava, Megan McLaughlin, Huimin Zhang, Traver Hart, Xu Feng, Mengfan Tang, Lei Li, Zhen Chen, Junjie Chen, Dan Su, Rui Wang
Publikováno v:
DNA Repair (Amst)
Ataxia Telangiectasia and Rad3-Related kinase (ATR) is a master regulator of genome maintenance, and participates in DNA replication and various DNA repair pathways. In a genome-wide screen for ATR-dependent fitness genes, we identified a previously
Publikováno v:
EMBO Rep
Replication across oxidative DNA lesions can give rise to mutations that pose a threat to genome integrity. How such lesions, which escape base excision repair, get removed without error during replication remains unknown. Our PCNA-based screen to un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c89919ee4e5b6d994be43bef3b4724b0
https://europepmc.org/articles/PMC7271331/
https://europepmc.org/articles/PMC7271331/
Autor:
Dan Su, Antrix Jain, Chao Wang, Mrinal Srivastava, Sung Yun Jung, Litong Nie, Jun Qin, Zhen Chen, Yun Xiong, Junjie Chen, Xu Feng, Huimin Zhang, Mengfan Tang
Publikováno v:
Mol Cell Proteomics
Adenosine monophosphate-activated protein kinase (AMPK) is an obligate heterotrimer that consists of a catalytic subunit (α) and two regulatory subunits (β and γ). AMPK is a key enzyme in the regulation of cellular energy homeostasis. It has been
Autor:
Rui Wang, Chao Wang, Junjie Chen, Huimin Zhang, Xu Feng, Xi Shen, Mengfan Tang, Litong Nie, Dan Su, Glen Traver Hart, Mrinal Srivastava, Chen Zhen, Lei Li, Megan E. McLaughlin
SummaryATR kinase is a master regulator of genome maintenance and participates in DNA replication and various DNA repair pathways. In a genome-wide screening for ATR-dependent fitness genes, we identified a previously uncharacterized gene, C17orf53,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f30e287ba46c7b8fdcc4f5a45793dad
https://doi.org/10.1101/758722
https://doi.org/10.1101/758722
Autor:
Zhen Chen, Xu Feng, Huimin Zhang, Junjie Chen, Chao Wang, Yin Ye, Yun Xiong, Dan Cao, John A. Tainer, Mengfan Tang, Zu Ye, Mrinal Srivastava
Publikováno v:
Nucleic Acids Research
Interstrand crosslinks (ICLs) are highly toxic DNA lesions that are repaired via a complex process requiring the coordination of several DNA repair pathways. Defects in ICL repair result in Fanconi anemia, which is characterized by bone marrow failur
Autor:
Xu Feng, Traver Hart, Junjie Chen, Chunchao Zhang, Yunfei Wang, Medina Colic, Mengfan Tang, Dan Su, Chao Wang
Publikováno v:
DNA Repair (Amst)
DNA damage response (DDR) is critically important for cell survival, genome maintenance, and its defect has been exploited therapeutically in cancer treatment. Many DDR-targeting agents have been generated and have entered the clinic and/or clinical