Zobrazeno 1 - 10
of 20
pro vyhledávání: '"L. Barbosa"'
Autor:
Berend Snijder, Francisco Corzana, Charlotte Baker, Claudia C. Faria, Amrita Samanta, Panagis Filippakopoulos, Nuno L. Barbosa-Morais, Marta C. Marques, João Conde, Daniel Picard, Marc Remke, Gonçalo J. L. Bernardes, Yuhang Liu, Tânia Carvalho, Ruth A. Pumroy, Florian Sieglitz, Sohyon Lee, Vera Y. Moiseenkova-Bell, Sandra H. Vaz, Bárbara B. Sousa, Rafael Roque, Bernardo P. de Almeida, Elvira P. Leites, Michael Weller, Seungil Han, Vanessa Alexandra Morais, Tobias Weiss, Tiago Rodrigues, Ana Guerreiro, Maike Langini
Publikováno v:
ACS Central Science
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Central Science, Vol 7, Iss 5, Pp 868-881 (2021)
ACS Central Science, 7 (5)
ACS central science
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Central Science, Vol 7, Iss 5, Pp 868-881 (2021)
ACS Central Science, 7 (5)
ACS central science
The use of computational tools to identify biological targets of natural products with anticancer properties and unknown modes of action is gaining momentum. We employed self-organizing maps to deconvolute the phenotypic effects of piperlongumine (PL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d11cc7bf34a63d2c20e06950f58cbf6
https://www.repository.cam.ac.uk/handle/1810/324869
https://www.repository.cam.ac.uk/handle/1810/324869
Publikováno v:
Stem Cell Transcriptional Networks-Methods and Protocols
Methods in Molecular Biology ISBN: 9781071603000
Methods in Molecular Biology
Methods in Molecular Biology-Stem Cell Transcriptional Networks
Methods in Molecular Biology ISBN: 9781071603000
Methods in Molecular Biology
Methods in Molecular Biology-Stem Cell Transcriptional Networks
Alternative splicing (AS) generates functionally distinct transcripts and is involved in multiple cellular processes, including stem cell differentiation. Several epithelial-to-mesenchymal transition-related splicing factors have also been associated
Autor:
Nuno L. Barbosa-Morais, Rui D. Silva, Ricardo Matos, Pedro Prudêncio, Om Singh Rathore, Margarida N. Tiago, Jean-Yves Roignant, Mariana Ascensão-Ferreira, Rui Gonçalo Martinho, Célia Carvalho, Bruno Marques, Raquel P. Andrade
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
RNA
RNA, vol. 26, no. 12, pp. 1935-1956
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
RNA
RNA, vol. 26, no. 12, pp. 1935-1956
© 2020 Rathore et al. This article is distributed exclusively by the RNASociety for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf593efaf1d68398718d45f75706b21
Autor:
Paul McCullagh, Emma Scott, David J. Elliott, Mads Daugaard, Oliver Thompson, John A. McGrath, Jennifer Munkley, Htoo Zarni Oo, Simon Cockell, Lorna W. Harries, Kathleen Cheung, Bridget A. Knight, Sebastian Oltean, Nuno L. Barbosa-Morais, Hanna A Zielinska, Karen E. Livermore, Gerald Hysenaj, Ingrid Ehrmann, Malcolm Crundwell, Teresa Mendes Maia, S R Gokul Krishnan, Ling Li
Prostate is the most frequent cancer in men. Prostate cancer progression is driven by androgen steroid hormones, and delayed by androgen deprivation therapy (ADT). Androgens control transcription by stimulating androgen receptor (AR) activity, yet al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0321ab6dd9c41d6bec34a9670e96dd88
https://doi.org/10.1101/629618
https://doi.org/10.1101/629618
Autor:
Bernardo P. de Almeida, Gonçalo J. L. Bernardes, Charlotte Baker, Nuno L. Barbosa-Morais, Tiago Rodrigues
Publikováno v:
Bioorganic & Medicinal Chemistry
We report the design, synthesis and biological evaluation of natural product-drug conjugates for treatment of prostate cancers over-expressing the transient receptor potential vanilloid 1 (TRPV1) channel. We validate the relevance of TRPV1 as a targe
Autor:
Luisa Capalbo, Gabriel Lopez-Berestein, Robert C. Bast, David D.L. Bowtell, Warren S.-L. Liao, David M. Glover, Nuno L. Barbosa-Morais, Pablo E. Vivas-Mejia, Ahmed Ashour Ahmed, Geoffrey Bartholomeusz, Zhen Lu, Dariush Etemadmoghadam, Xiao Feng Le, Rodrigo Jacamo, Geoffrey Grandjean, Anil K. Sood, Michael Andreeff, Nicholas B. Jennings
SummaryRegulators of mitosis have been successfully targeted to enhance response to taxane chemotherapy. Here, we show that the salt inducible kinase 2 (SIK2) localizes at the centrosome, plays a key role in the initiation of mitosis, and regulates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e336e470a9c5d6bc0c9fed5f13b9a8a2
https://ora.ox.ac.uk/objects/uuid:dc7cd1a4-f389-4870-b921-4c723d5915f5
https://ora.ox.ac.uk/objects/uuid:dc7cd1a4-f389-4870-b921-4c723d5915f5
Autor:
Natalie P. Thorne, Ana Rita Grosso, Nuno L. Barbosa-Morais, Godfrey Grech, Maria Carmo-Fonseca, Marieke von Lindern, Anita Quintal Gomes, Sandra Caldeira
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nucleic Acids Research, 36(15), 4823-4832. Oxford University Press
Nucleic acids research, 36(15), 4823-4832. Oxford University Press
Nucleic Acids Research
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nucleic Acids Research, 36(15), 4823-4832. Oxford University Press
Nucleic acids research, 36(15), 4823-4832. Oxford University Press
Nucleic Acids Research
© 2008 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distributi
Publikováno v:
FEBS Journal. 273:4807-4816
U2 snRNP auxiliary factor (U2AF) is an essential heterodimeric splicing factor composed of two subunits, U2AF(65) and U2AF(35). During the past few years, a number of proteins related to both U2AF(65) and U2AF(35) have been discovered. Here, we revie
Autor:
Fang Bian, Eugene A. Volpe, Flavia L. Barbosa, Flavia S. A. Pelegrino, Cintia S. de Paiva, Rosa M. Corrales, Stephen C. Pflugfelder
Publikováno v:
Arthritis Research & Therapy
Introduction The lacrimal gland (LG) of the CD25-/- model of Sjögren’s syndrome (SS) has high interleukin (IL)-17, IL-13 and interferon-gamma (IFN-γ) cytokines. The specific contribution of these cytokines to the onset and severity of dacryoadeni
Autor:
Nuno L. Barbosa-Morais, Vladimir Benes, Matthew C Wollerton, Maria Carmo-Fonseca, Juan Valcárcel, Christopher W.J. Smith, Anita Quintal Gomes, Teresa R. Pacheco, Wilhelm Ansorge
Publikováno v:
Journal of Biological Chemistry. 279:27039-27049
U2 small nuclear ribonucleoprotein auxiliary factor small subunit (U2AF(35)) is encoded by a conserved gene designated U2AF1. Here we provide evidence for the existence of alternative vertebrate transcripts encoding different U2AF(35) isoforms. Three