Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jorge Cruz-Reyes"'
Autor:
Jana Gomez, Jair L. Siqueira-Neto, Drake M. Mellott, Jorge Cruz-Reyes, Emily Desormeaux, Claudia Calvet Alvarez, Jean A. Bernatchez, Thomas D. Meek, Linfeng Li, Xiang Zhai, Elizabeth Alvarez Hernandez, Balachandra Chenna, James H. McKerrow
Publikováno v:
J Med Chem
Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaff
Autor:
Jorge Cruz-Reyes, Andrew Hillhouse, Daniel Camilo Osorio Hurtado, Alasdair Ivens, Xiuren Zhang, Pawan K. Doharey, Joshua Meehan, Zachary T Goodall, Achim Schnaufer, Vikas Kumar, James J. Cai
Publikováno v:
Kumar, V, Ivens, A, Goodall, Z, Meehan, J, Doharey, P K, Hillhouse, A, Hurtado, D O, Cai, J J, Zhang, X, Schnaufer, A & Cruz-Reyes, J 2020, ' Site-specific and mRNA-specific control of accurate mRNA editing by a helicase complex in trypanosomes ', RNA, vol. 26, no. 10, rna.076513.120 . https://doi.org/10.1261/rna.076513.120
RNA
RNA
Trypanosome U-insertion/deletion RNA editing in mitochondrial mRNAs involves guide RNAs (gRNAs) and the auxiliary RNA editing substrate binding complex (RESC) and RNA editing helicase 2 complex (REH2C). RESC and REH2C stably copurify with editing mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7544f1407045fc8df53ea00d87dc63e7
https://www.pure.ed.ac.uk/ws/files/164850025/RNA_2020_Kumar_rna.076513.120.pdf
https://www.pure.ed.ac.uk/ws/files/164850025/RNA_2020_Kumar_rna.076513.120.pdf
Autor:
Jorge Cruz-Reyes, Joshua Meehan, Karissa Hughes, Pawan K. Doharey, Shelly Gulati, Vikas Kumar, Mary Grace Martinez, Blaine H. M. Mooers
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 4, p e0211525 (2019)
PLoS ONE, Vol 14, Iss 4, p e0211525 (2019)
Uridylate insertion/deletion RNA editing inTrypanosoma bruceiis a complex system that is not found in humans, so there is interest in targeting this system for drug development. This system uses hundreds of small non-coding guide RNAs (gRNAs) to modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86526f60b24f7c8ab3a3e12703e89126
https://doi.org/10.1101/524702
https://doi.org/10.1101/524702
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12235 (2010)
PLoS ONE, Vol 5, Iss 8, p e12235 (2010)
Mitochondrial mRNA editing in Trypanosoma brucei requires the specific interaction of a guide RNA with its cognate mRNA. Hundreds of gRNAs are involved in the editing process, each needing to target their specific editing domain within the target mes
Autor:
Kari Halbig, Anastasia Sacharidou, Mónica De Nova-Ocampo, Catherine Cifuentes-Rojas, Jorge Cruz-Reyes
Publikováno v:
Nucleic Acids Research
Trypanosome RNA editing by uridylate insertion or deletion cycles is a mitochondrial mRNA maturation process catalyzed by multisubunit complexes. A full-round of editing entails three consecutive steps directed by partially complementary guide RNAs: