Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Gil, McVean"'
Autor:
Gil McVean, Adrian Cortes, Simon Sheard, Alexander J. Mentzer, Hill Avs., Thomas J. Littlejohns, Naomi E. Allen, Nicole Brenner, R Almond, Tim Waterboer, Rory Collins, Michael Hill, Amanda Y. Chong
BackgroundCertain infectious agents are recognised causes of cancer and potentially other chronic diseases. Identifying associations and understanding pathological mechanisms involving infectious agents and subsequent chronic disease risk will be pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e80cc588f70292ab1093749f31146c
http://hdl.handle.net/10029/626407
http://hdl.handle.net/10029/626407
Autor:
Michael Krause, Susana Campino, Zamin Iqbal, Dominic P. Kwiatkowski, Juliana M. Sá, Kiran V. Garimella, Thomas E. Wellems, Eleanor Drury, Mihir Kekre, Gil McVean
Publikováno v:
Genome Res
The characterization of de novo mutations in regions of high sequence and structural diversity from whole-genome sequencing data remains highly challenging. Complex structural variants tend to arise in regions of high repetitiveness and low complexit
Publikováno v:
Nature genetics
Cortes, A, Albers, P K, Dendrou, C A, Fugger, L & McVean, G 2020, ' Identifying cross-disease components of genetic risk across hospital data in the UK Biobank ', Nature Genetics, vol. 52, no. 1, pp. 126-134 . https://doi.org/10.1038/s41588-019-0550-4
Cortes, A, Albers, P K, Dendrou, C A, Fugger, L & McVean, G 2020, ' Identifying cross-disease components of genetic risk across hospital data in the UK Biobank ', Nature Genetics, vol. 52, no. 1, pp. 126-134 . https://doi.org/10.1038/s41588-019-0550-4
Genetic risk factors frequently affect multiple common human diseases, providing insight into shared pathophysiological pathways and opportunities for therapeutic development. However, systematic identification of genetic profiles of disease risk is
Autor:
Gil McVean, Patrick K. Albers, Yan Wong, Jerome Kelleher, Anthony Wilder Wohns, Chaimaa Fadil
Publikováno v:
Nature genetics
Inferring the full genealogical history of a set of DNA sequences is a core problem in evolutionary biology, because this history encodes information about the events and forces that have influenced a species. However, current methods are limited, an
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009287 (2021)
PLoS Computational Biology
PLoS Computational Biology
There is an abundance of malaria genetic data being collected from the field, yet using these data to understand the drivers of regional epidemiology remains a challenge. A key issue is the lack of models that relate parasite genetic diversity to epi
Publikováno v:
Nature biotechnology
Exponentially increasing amounts of unprocessed bacterial and viral genomic sequence data are stored in the global archives. The ability to query these data for sequence search terms would facilitate both basic research and applications such as real-
There is an abundance of malaria genetic data being collected from the field, yet using this data to understand features of regional epidemiology remains a challenge. A key issue is the lack of models that relate parasite genetic diversity to epidemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7d8f9c0d5807da00c375637edf6f1de
https://doi.org/10.1101/2020.08.27.269928
https://doi.org/10.1101/2020.08.27.269928
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009723 (2021)
PLoS Genetics
PLoS Genetics
Inherited genetic variation contributes to individual risk for many complex diseases and is increasingly being used for predictive patient stratification. Previous work has shown that genetic factors are not equally relevant to human traits across ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77863ea33df1d1351dc40130c798695a
https://doi.org/10.1101/2020.07.17.208280
https://doi.org/10.1101/2020.07.17.208280
Autor:
Gil McVean, Eleanor Drury, Juliana M. Sá, Michael Krause, Mihir Kekre, Dominic P. Kwiatkowski, Kiran V. Garimella, Thomas E. Wellems, Zamin Iqbal, Susana Campino
The characterization ofde novomutations in regions of high sequence and structural diversity from whole genome sequencing data remains highly challenging. Complex structural variants tend to arise in regions of high repetitiveness and low complexity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea353853623895c8cebdfccbfb9e4c2b
Autor:
Angela R. McLean, Sarah Fidler, Kuan-Hsiang Gary Huang, Gil McVean, Philip J. R. Goulder, John Frater, Duncan S. Palmer, Cloete van Vuuren, Rodney E. Phillips, Dominique Goedhals, Roger L. Shapiro, Annette Oxenius, Isaac Turner
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 10 (1)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 10 (1)
Differences among hosts, resulting from genetic variation in the immune system or heterogeneity in drug treatment, can impact within-host pathogen evolution. Genetic association studies can potentially identify such interactions. However, extensive a