Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ansuman T. Satpathy"'
Autor:
Jo Anne Stratton, Sorana Morrissy, Nizar J. Bahlis, Weiqiang Zhou, Ansuman T. Satpathy, Sarthak Sinha, Hongkai Ji, Arzina Jaffer, Jeff Biernaskie
Publikováno v:
Genomics, Proteomics & Bioinformatics
Genomics, Proteomics & Bioinformatics, Vol 19, Iss 2, Pp 172-190 (2021)
Genomics, Proteomics & Bioinformatics, Vol 19, Iss 2, Pp 172-190 (2021)
How distinct transcriptional programs are enacted to generate cellular heterogeneity and plasticity, and enable complex fate decisions are important open questions. One key regulator is the cell’s epigenome state that drives distinct transcriptiona
Publikováno v:
Molecular Cell. 81:2272-2274
Pritykin et al. (2021) establish a comprehensive chromatin atlas of CD8+ T cell dysfunction in chronic viral infection and cancer via analysis of bulk and single-cell ATAC-seq datasets across immune challenges. These results unify the classification
Publikováno v:
Cell
bioRxiv
bioRxiv
SUMMARYThe long noncoding RNA (lncRNA) XIST establishes X chromosome inactivation (XCI) in female cells in early development and thereafter is thought to be largely dispensable. Here we show XIST is continually required in adult human B cells to sile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9bdddeb8782fa56f735921b0e3d515
https://europepmc.org/articles/PMC9196326/
https://europepmc.org/articles/PMC9196326/
Autor:
Leif S. Ludwig, Rany M. Salem, Jacob C. Ulirsch, Joel N. Hirschhorn, Ansuman T. Satpathy, Caleb A. Lareau, Erik L. Bao, Michael H. Guo, Christian Benner, Jason D. Buenrostro, Vijay G. Sankaran, Hilary K. Finucane, Martin J. Aryee, Vinay K. Kartha
Publikováno v:
Nature Genetics. 51:683-693
Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation represent substantial challenges to elucidating mechanisms of trait-associated genetic variation. Here we perform genetic fine-mapping for blood cell traits i
Autor:
Bryan A. Stevens, Taia T. Wang, Scott D. Boyd, Abigail E. Powell, Bence Daniel, Arjun Rustagi, Theodore S. Jardetzky, Sandra C. A. Nielsen, Ramona A. Hoh, Howard Y. Chang, Kathryn E. Yost, Molly Hunter, Peter S. Kim, Angela J. Rogers, Benjamin A. Pinsky, Ji-Yeun Lee, Kari C. Nadeau, Catherine A. Blish, Ansuman T. Satpathy, Fan Yang, Katharina Röltgen, Grace H. Jean, Katherine J. L. Jackson, Ana R. Otrelo-Cardoso, Javaria Najeeb
Publikováno v:
Cell Host & Microbe
B cells are critical for the production of antibodies and protective immunity to viruses. Here we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) display ea
Autor:
Howard Y. Chang, Peng Xu, Kevin R. Parker, Thomas J. Wandless, Zinaida Good, Elena Sotillo, Hima Anbunathan, Yanyan Qi, Robbie G. Majzner, Panayiotis Vandris, Ansuman T. Satpathy, Ling-chun Chen, Rachel C. Lynn, Crystal L. Mackall, Evan W. Weber, Andrew J. Gentles, Meena Malipatlolla, John Lattin
SUMMARYT cell exhaustion limits immune responses against cancer and is a major cause of resistance to CAR-T cell therapeutics. Using a model wherein tonic CAR signaling induces hallmark features of exhaustion, we employed a drug-regulatable CAR to te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d0cb492f502fad83e1351f817e8403
https://doi.org/10.1101/2020.01.26.920496
https://doi.org/10.1101/2020.01.26.920496
Autor:
Kevin R. Parker, Tamas L. Horvath, Ryan A. Flynn, Aditi Limaye, Yanyan Qi, Peter C DeWeirdt, Maxwell R. Mumbach, Jan E. Carette, Quanming Shi, Carolyn R. Bertozzi, Yuki Yasumoto, Mia Madel Alfajaro, Howard Y. Chang, Jin Wei, Cameron O. Schmitz, Julia A. Belk, Craig B. Wilen, Ansuman T. Satpathy, Elizabeth Woo
Publikováno v:
Cell. 184:2394-2411.e16
SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS), we identified 309 host proteins that bind the SARS-CoV-2 RNA during active infection. Int
Autor:
Ansuman T. Satpathy, Tieu, Elena Sotillo, DeBourcy C, Robbie G. Majzner, Crystal L. Mackall, Rachel C. Lynn, David Gennert, Robert C. Jones, Howard Y. Chang, Peng Xu, Zinaida Good, Jeffrey M. Granja, Hima Anbunathan, Evan W. Weber
SUMMARYCAR T cells mediate antitumor effects in a small subset of cancer patients, but dysfunction due to T cell exhaustion is an important barrier to progress. To investigate the biology of exhaustion in human T cells expressing CAR receptors, we us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab659eb54cd5c6335ee8d4dfe8197073
https://doi.org/10.1101/653725
https://doi.org/10.1101/653725
Autor:
Jeffrey M. Granja, Kavita Y. Sarin, Daniel K. Wells, Kathryn E. Yost, Chunlin Wang, Howard Y. Chang, Mark M. Davis, Ryanne A. Brown, Anne Lynn S. Chang, Yanyan Qi, Katherine McNamara, Christina Curtis, Rohit Gupta, Ansuman T. Satpathy, Samantha L. Bucktrout, Robin Kageyama
Immunotherapies that block inhibitory checkpoint receptors on T cells have transformed the clinical care of cancer patients. However, which tumor-specific T cells are mobilized following checkpoint blockade remains unclear. Here, we performed paired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38d59db201d0c0f743eec7f7b62e91a
https://doi.org/10.1101/648899
https://doi.org/10.1101/648899
Autor:
William J. Greenleaf, Jean Wang, Darisha Jhutty, Grace X.Y. Zheng, Kathryn E. Yost, Yifeng Yin, Preyas Shah, Corey M. Nemec, Ansuman T. Satpathy, Li Wang, Francesca Meschi, M. Ryan Corces, Howard Y. Chang, Jason C. Bell, Jeffrey M. Granja, Geoffrey P. McDermott, Paul G. Giresi, Anne Lynn S. Chang, Yanyan Qi, Brett N. Olsen, Maxwell R. Mumbach, Sarah E. Pierce
Publikováno v:
Nat Biotechnol
Understanding complex tissues requires single-cell deconstruction of gene regulation with precision and scale. Here we present a massively parallel droplet-based platform for mapping transposase-accessible chromatin in tens of thousands of single cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0cb42476cb5620faa7fa1f6a0f5a06