Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Afaf H. El-Sagheer, Ivanhoe K. H. Leung, Tom Brown, Michael A. McDonough, Anthony Tumber, Nok Yin Tam, Caitlin Clunie-O'Connor, Dong Zhang, Marina Demetriades, Shifali Shishodia, Wei Shen Aik, Thomas M. Leissing, Eidarus Salah, Pratheesh Maheswaran, Yi Min Ng, Christopher J. Schofield
Publikováno v:
Journal of Medicinal Chemistry
FTO catalyzes the Fe(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N6-methyladenosine (m6A) in mRNA. FTO is a proposed target for anti-cancer therapy. Using information from crystal structures of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639c2be01f207a01903964a703615f30
https://ora.ox.ac.uk/objects/uuid:839b007e-dd4b-4bc0-ac22-ed37a4bd5169
https://ora.ox.ac.uk/objects/uuid:839b007e-dd4b-4bc0-ac22-ed37a4bd5169
Publikováno v:
Journal of medicinal chemistry. 64(11)
Factor inhibiting hypoxia-inducible factor (FIH) is a JmjC domain 2-oxogluarate and Fe(II)-dependent oxygenase that catalyzes hydroxylation of specific asparagines in the C-terminal transcriptional activation domain of hypoxia-inducible factor alpha
Autor:
Michael A. McDonough, Holger B. Kramer, Timothy D. W. Claridge, Ming Yang, Wei Ge, Rasheduzzaman Chowdhury, Christopher J. Schofield, Bernhard Schmierer, Mathew L. Coleman, Peter J. Ratcliffe, Benedikt M. Kessler, Lingzhi Gong
Publikováno v:
Journal of Biological Chemistry
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Factor-inhibiting hypoxia-inducible factor (FIH) catalyzes the β-hydroxylation of an asparagine residue in the C-terminal transcriptional activation domain of the hypoxia inducible factor (HIF), a modification that negatively regulates HIF transcrip
Autor:
Emily Flashman, Kirsty S. Hewitson, Dominic Ehrismann, Nicolas Mathioudakis, Peter J. Ratcliffe, David N. Genn, Christopher J. Schofield
Publikováno v:
Biochemical Journal. 401:227-234
The activity and levels of the metazoan HIF (hypoxia-inducible factor) are regulated by its hydroxylation, catalysed by 2OG (2-oxoglutarate)- and Fe(II)-dependent dioxygenases. An oxygen consumption assay was developed and used to study the relations
Autor:
Atsushi Yamamoto, Marion S. Schmidt-Zachmann, Armin Thalhammer, Ming Yang, Gail M. Preston, James S. O. McCullagh, Alexander Wolf, Chia Hua Ho, Phebee Liu-Yi, Adam P. Hardy, Zhihong Zhang, Peter J. Ratcliffe, Adam Zayer, Carol V. Robinson, Tianshu Feng, Benedikt M. Kessler, Nikita D. Loik, Mathew L. Coleman, Rok Sekirnik, Timothy D. W. Claridge, Muhammad Mukram Mohamed Mackeen, Refaat B. Hamed, Miao Jiang, Matthew E. Cockman, Rasheduzzaman Chowdhury, Christoph Loenarz, Christopher J. Schofield, David C. Trudgian, Nicolas Granatino, Wei Ge, Yuliya Gordiyenko, Lingzhi Gong
Publikováno v:
Nature chemical biology. 8(12)
The finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription raises questions as to whether the translation machinery and prokaryotic proteins are analogously modified. Escherichia coli ycfD is a growth-regulating 2-oxogl
Autor:
David W. Wegman, Michael A. McDonough, Dack Kevin Neil, Marina Demetriades, Sergey N. Krylov, Louise J. Walport, Eleanor A.L. Bagg, Mun Chiang Chan, Jerome Ma, Svetlana M. Krylova, Wei Shen Aik, Esther C. Y. Woon, Christopher J. Schofield
Publikováno v:
Journal of Medicinal Chemistry
2-Oxoglutarate-dependent nucleic acid demethylases are of biological interest because of their roles in nucleic acid repair and modification. Although some of these enzymes are linked to physiology, their regulatory roles are unclear. Hence, there is
Autor:
David C. Trudgian, Peter J. Ratcliffe, Rachelle S. Singleton, Norma Masson, Benedikt M. Kessler, Melroy X. Miranda, Rok Sekirnik, Ya-Min Tian, Lucy J. A. Ambrose, Christopher J. Schofield
Publikováno v:
EMBO reports
EMBO Reports
EMBO Reports
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity HIF asparaginyl hydroxylase (FIH) is shown to be strikingly more sensitive to peroxide than the HIF prolyl hydroxylases, indicating that hypoxia and oxidati
Autor:
Chris Church, Jasmin Mecinović, Sheena Lee, Roger D. Cox, Eleanor A.L. Bagg, Lee Moir, Frances M. Ashcroft, Christopher J. Schofield, Mohamed M. Quwailid, Robert M. J. Deacon, Thomas Gerken, James S. McTaggart, Angela Lee
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 5, Iss 8, p e1000599 (2009)
PLoS Genetics, Vol 5, Iss 8, p e1000599 (2009)
Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within i
Autor:
Kirsty S. Hewitson, Anthony P. Coll, Inês Barroso, Christophe Girard, Xavier Prieur, I. Sadaf Farooqi, Thomas Gerken, Christopher J. Schofield, Patrik Rorsman, Sharon Cunliffe, Peter Robins, Barbara Sedgwick, Frances M. Ashcroft, Juris Galvanovskis, Chris P. Ponting, Zorica Jovanovic, Michael A. McDonough, Vladimir Saudek, Marcella Ma, Luke A. McNeill, Celia J. Webby, Tomas Lindahl, Stephen O'Rahilly, Giles S.H. Yeo, Yi-Chun Loraine Tung
Publikováno v:
Science
Science, American Association for the Advancement of Science, 2007, 318 (5855), pp.1469-1472. ⟨10.1126/science.1151710⟩
Science, American Association for the Advancement of Science, 2007, 318 (5855), pp.1469-1472. ⟨10.1126/science.1151710⟩
Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs with Fe(II)- and 2-oxoglutarate–dependent oxygenases. We fi