Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Haitao Yang, H. T. Henry Chan, Anthony Tumber, Petra Lukacik, Fernanda Duarte, Martin A. Walsh, Lennart Brewitz, Eidarus Salah, Tobias John, Tika R. Malla, Christopher J. Schofield, Claire Strain-Damerell, Zihe Rao, Pratheesh Maheswaran, C. David Owen
Publikováno v:
Chemical Communications
The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some
Autor:
Gen Li, Xiao-Pan Chen, Yu-Hang Yan, Ji Deng, Jürgen Brem, Christopher J. Schofield, You-Cai Xiao, Kai-Rong Zhu, Guo-Bo Li, Fener Chen, Jun-Lin Yu
Publikováno v:
Chemical Communications (Cambridge, England)
Chiral 3-substituted benzoxaboroles were designed as carbapenemase inhibitors and efficiently synthesised via asymmetric Morita–Baylis–Hillman reaction. Some of the benzoxaboroles were potent inhibitors of clinically relevant carbapenemases and r
Autor:
Victor H. Villar, Lynsey M. Meikle, Sheila Brown, Josephine Bunch, Emily K. Osterweil, Richard J. A. Goodwin, Maya Kamat, RuAngelie Edrada-Ebel, Justin J. J. van der Hooft, Michael J. Ormsby, Alex Dexter, Daniel Walker, Gillian Douce, Nicole Strittmatter, Julia M. Edgar, John G. Swales, Saverio Tardito, Jasper C. Komen, Ryan A. Bragg, Daniel M. Wall, Andrew S. MacDonald, Christopher J. Schofield, Heather Hulme, Stephanie A. Barnes, Richard Burchmore, Simon Milling
Publikováno v:
Hulme, H, Meikle, L M, Strittmatter, N, van der Hooft, J J J, Swales, J, Bragg, R A, Villar, V H, Ormsby, M J, Barnes, S, Brown, S L, Dexter, A, Kamat, M T, Komen, J C, Walker, D, Milling, S, Osterweil, E K, MacDonald, A S, Schofield, C J, Tardito, S, Bunch, J, Douce, G, Edgar, J M, Edrada-Ebel, R, Goodwin, R J A, Burchmore, R & Wall, D M 2020, ' Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication ', Science Advances, vol. 6, no. 11, eaax6328, pp. 1-10 . https://doi.org/10.1126/sciadv.aax6328
Science Advances 6 (2020) 11
Science Advances
Science Advances, 6(11)
Hulme, H, Meikle, L M, Strittmatter, N, van der Hooft, J J J, Swales, J, Bragg, R A, Villar, V H, Ormsby, M J, Barnes, S, Brown, S L, Dexter, A, Kamat, M T, Komen, J C, Walker, D, Milling, S, Osterweil, E K, MacDonald, A S, Schofield, C J, Tardito, S, Bunch, J, Douce, G, Edgar, J M, Edrada-Ebel, R, Goodwin, R J A, Burchmore, R & Wall, D M 2020, ' Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication ', Science Advances, vol. 6, no. 11, pp. eaax6328 . https://doi.org/10.1126/sciadv.aax6328
Science Advances 6 (2020) 11
Science Advances
Science Advances, 6(11)
Hulme, H, Meikle, L M, Strittmatter, N, van der Hooft, J J J, Swales, J, Bragg, R A, Villar, V H, Ormsby, M J, Barnes, S, Brown, S L, Dexter, A, Kamat, M T, Komen, J C, Walker, D, Milling, S, Osterweil, E K, MacDonald, A S, Schofield, C J, Tardito, S, Bunch, J, Douce, G, Edgar, J M, Edrada-Ebel, R, Goodwin, R J A, Burchmore, R & Wall, D M 2020, ' Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication ', Science Advances, vol. 6, no. 11, pp. eaax6328 . https://doi.org/10.1126/sciadv.aax6328
Discovery of novel bacterial metabolites reveals an unprecedented role for the microbiome in gut-brain axis communication.
Alterations to the gut microbiome are associated with various neurological diseases, yet evidence of causality and identit
Alterations to the gut microbiome are associated with various neurological diseases, yet evidence of causality and identit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6425116aa951a24b358ad25d9af7f085
https://doi.org/10.1126/sciadv.aax6328
https://doi.org/10.1126/sciadv.aax6328
Autor:
Malcolm G. P. Page, Jürgen Brem, Christopher J. Schofield, Thomas M. Leissing, Pauline A. Lang
Publikováno v:
Antimicrobial Agents and Chemotherapy
β-Lactam antibiotics are presently the most important treatments for infections by pathogenic Escherichia coli, but their use is increasingly compromised by β-lactamases, including the chromosomally encoded class C AmpC serine-β-lactamases (SBLs).
Autor:
Opher Gileadi, Hannah T Baddock, J.A. Newman, Yuliana Yosaatmadja, Christopher J. Schofield, Peter J. McHugh
Publikováno v:
DNA Repair
Unrepaired, or misrepaired, DNA damage can contribute to the pathogenesis of a number of conditions, or disease states; thus, DNA damage repair pathways, and the proteins within them, are required for the safeguarding of the genome. Human SNM1A is a
Autor:
Pauline A. Lang, James Spencer, Philip Hinchliffe, Catherine L. Tooke, Jürgen Brem, Adrian J. Mulholland, Christopher J. Schofield
Publikováno v:
Tooke, C, Hinchliffe, P, Pauline, L, Mulholland, A, Brem, J, Schofield, C J & Spencer, J 2019, ' Molecular Basis of Class A β-lactamase Inhibition by Relebactam ', Antimicrobial Agents and Chemotherapy . https://doi.org/10.1128/AAC.00564-19, https://doi.org/10.1128/AAC.00564-19
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
β-Lactamase production is the major β-lactam resistance mechanism in Gram-negative bacteria. β-Lactamase inhibitors (BLIs) efficacious against serine β-lactamase (SBL) producers, especially strains carrying the widely disseminated class A enzymes
Autor:
Ricky Cain, Jonathan M. Tyrrell, Jürgen Brem, Michael A. McDonough, Sean W. Robinson, Matthew B. Avison, Samuel T. Cahill, Christopher T. Lohans, Timothy R. Walsh, Colin W. G. Fishwick, Karina Calvopiña, Iva Navratilova, Christopher J. Schofield
Publikováno v:
Cahill, S T, Tyrrell, J M, Navratilova, I H, Calvopiña, K, Robinson, S W, Lohans, C T, McDonough, M A, Cain, R, Fishwick, C W G, Avison, M B, Walsh, T R, Schofield, C J & Brem, J 2019, ' Studies on the Inhibition of AmpC and other β-Lactamases by Cyclic Boronates ', Biochimica et Biophysica Acta (BBA)-General Subjects, vol. 1863, no. 4, pp. 742-748 . https://doi.org/10.1016/j.bbagen.2019.02.004
BackgroundThe β-lactam antibiotics represent the most successful drug class for treatment of bacterial infections. Resistance to them, importantly via production of β-lactamases, which collectively are able to hydrolyse all classes of β-lactams, t
Autor:
Hanna Tarhonskaya, Lynette M. Phee, Emily Flashman, Inga Pfeffer, Christopher J. Schofield, Jürgen Brem, Sarah E. Wilkins, Rebecca E. J. Geffen, David W. Wareham, Anne Makena
Publikováno v:
Journal of Antimicrobial Chemotherapy
OBJECTIVES: Metallo-β-lactamase (MBL)-based resistance is a threat to the use of most β-lactam antibiotics. Multiple variants of the New Delhi MBL (NDM) have recently been reported. Previous reports indicate that the substitutions affect NDM activi
Autor:
Akane Kawamura, Mun Chiang Chan, Christopher J. Schofield, Timothy D. W. Claridge, Anna M. Rydzik, Hanna Tarhonskaya, Ivanhoe K. H. Leung, Emily Flashman, Nikita D. Loik, James S. O. McCullagh
Publikováno v:
Nature Communications
Accumulation of (R)-2-hydroxyglutarate in cells results from mutations to isocitrate dehydrogenase that correlate with cancer. A recent study reports that (R)-, but not (S)-2-hydroxyglutarate, acts as a co-substrate for the hypoxia-inducible factor p
Autor:
Ineke P. Stolze, Neil J. Oldham, Benoît M. R. Liénard, Ana Conejo-García, Peter J. Ratcliffe, Christoph Loenarz, Christopher J. Schofield
Publikováno v:
Chemical communications (Cambridge, England). (47)
Known and potential aspirin metabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-alpha in cells.