Zobrazeno 1 - 10
of 1 646
pro vyhledávání: ''
Autor:
Henry Yang, Zhi-Hong Jiang, Zhen Long Ng, Yuin-Han Loh, Sue Yu, Jiamin Siew, Yuan Yuan Chew, Ernesto Guccione, Guanxu Ji, Yun Chau Long, Ying Ye, Wensheng Zhang, Wan Ning Lo, Jia Li, Qiang Wu
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:110-128
Chromatin modification contributes to pluripotency maintenance in embryonic stem cells (ESCs). However, the related mechanisms remain obscure. Here, we show that Npac, a "reader" of histone H3 lysine 36 trimethylation (H3K36me3), is required to maint
Publikováno v:
Methods
Circular RNAs with covalently linked ends are generated from many eukaryotic protein-coding genes when the pre-mRNA splicing machinery backsplices. These mature transcripts are resistant to digestion by exonucleases and typically have much longer hal
Autor:
Alejandro Gomez-Auli, Nicola Iovino, Michael Rauer, Dafne Ibarra-Morales, Mariana Schulte-Sasse, Francesco Cardamone, Leily Rabbani, Piergiuseppe Quarato, Fides Zenk, Germano Cecere
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications, 12 (1)
Nature Communications, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications, 12 (1)
Nature Communications, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development;
Autor:
Christian Dienemann, Isaac Fianu, Olexandr Dybkov, Henning Urlaub, Ying Chen, Patrick Cramer, Andreas Linden
Publikováno v:
Science. 374:883-887
Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription. We report the structure of the pretermination complex containing the human Int
Publikováno v:
Nucleic Acids Research
R-loops, which consist of a DNA/RNA hybrid and a displaced single-stranded DNA (ssDNA), are increasingly recognized as critical regulators of chromatin biology. R-loops are particularly enriched at gene promoters, where they play important roles in r
Autor:
Jonathan Zonszain, Ronna Shayevitch, Maram Hussein, Ifat Keydar, Galit Lev Maor, Gil Ast, Eran Meshorer, Dror Hollander, Matan Sorek, Luna Tammer, Ofir Hameiri, Yodfat Leader
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
In the earliest step of spliceosome assembly, the two splice sites flanking an intron are brought into proximity by U1 snRNP and U2AF along with other proteins. The mechanism that facilitates this intron looping is poorly understood. Using a CRISPR i
Autor:
Hyeonju Woo, Sumin Lee, Bo Bae Lee, Jae Seok Roe, TaeSoo Kim, SeoJung Youn, Min Kyung Lee, Soo Young Lee
Publikováno v:
Nucleic Acids Research
During RNA polymerase II (RNA Pol II) transcription, the chromatin structure undergoes dynamic changes, including opening and closing of the nucleosome to enhance transcription elongation and fidelity. These changes are mediated by transcription elon
Publikováno v:
Nucleic Acids Research
Transcription induced CAG repeat instability is associated with fatal neurological disorders. Genetic approaches found transcription-coupled nucleotide excision repair (TC-NER) factor CSB protein and TFIIS play critical roles in modulating the repeat
Autor:
Xiaoxiao Zhang, Xinmiao Wang, Guanghui Zhu, Ying Zhang, Xiaoyu Zhu, Jie Li, Ruike Gao, Zhe Wu, Haoyu Yang
Publikováno v:
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
Background. Tumor microenvironment (TME) takes a vital effect on the occurrence and development of cancer. Radix Rhei Et Rhizome (RRER, Da-Huang in pinyin), a classical Chinese herb, has been widely used in gastric cancer (GC) for many years in China
Publikováno v:
FEBS Letters. 595:1933-1948
Activated and promoter-bound heat-shock transcription factor 1 (HSF1) induces RNA polymerase II recruitment upon heat shock, and this is facilitated by the core Mediator in Drosophila and yeast. Another Mediator module, CDK8 kinase module (CKM), cons