Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ye Chen-Izu"'
Autor:
Donald M. Bers, Sridharan Rajamani, Leighton T. Izu, Bence Hegyi, Luiz Belardinelli, Tamás Bányász, Ye Chen-Izu
Publikováno v:
Circ Arrhythm Electrophysiol
Circulation. Arrhythmia and electrophysiology, vol 13, iss 4
Circulation. Arrhythmia and electrophysiology, vol 13, iss 4
Background: Rapid delayed rectifier K + current (I Kr ) and late Na + current (I NaL ) significantly shape the cardiac action potential (AP). Changes in their magnitudes can cause either long or short QT syndromes associated with malignant ventricula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f64585715516bb012928d8c38d8dd2
https://europepmc.org/articles/PMC7331791/
https://europepmc.org/articles/PMC7331791/
Publikováno v:
BIBM
Cardiotoxicity caused by drug candidates and chemical compounds that block hERG channels may lead to malignant ventricular arrhythmias and even sudden cardiac death (SCD). Various in-silico models have been built to predict the cardiotoxicity during
Autor:
Bence Hegyi, Tamás Bányász, Leighton T. Izu, Kenneth S. Ginsburg, Caroline Liu, Ye Chen-Izu, Stefano Morotti, Julie Bossuyt, Eleonora Grandi, Luiz Belardinelli, Donald M. Bers
Publikováno v:
Circulation. Arrhythmia and electrophysiology. 12(3)
Background: Heart failure (HF) is characterized by electrophysiological remodeling resulting in increased risk of cardiac arrhythmias. Previous reports suggest that elevated inward ionic currents in HF promote action potential (AP) prolongation, incr
Autor:
Ye Chen-Izu, Geoffrey S. Pitt, Peter J. Mohler, Walter J. Chazin, Donald M. Bers, Colleen E. Clancy, Mark B. Cannell, Lars S. Maier, Randall L. Rasmusson, Leighton T. Izu, Sridharan Rajamani, Jon T. Sack, Thomas J. Hund, Luiz Belardinelli, Hugues Abriel, Vladimir Yarov-Yarovoy, Eric A. Sobie, Richard W. Aldrich, Céline Marionneau, Eleonora Grandi, Nipavan Chiamvimonvat, Isabelle Deschenes, Robin M. Shaw, William A. Catterall, Victor A. Maltsev
Publikováno v:
The Journal of Physiology. 593:1347-1360
This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation-contraction coupling and arrhythmias:
Publikováno v:
Biophysical Journal. 91(1):95-112
Spontaneously generated calcium (Ca2+) waves can trigger arrhythmias in ventricular and atrial myocytes. Yet, Ca2+ waves also serve the physiological function of mediating global Ca2+ increase and muscle contraction in atrial myocytes. We examine the
Publikováno v:
Biophysical Journal. 110:101a
Objective: Under congenital or acquired pathological conditions, excessive mechanical stress in myocardium leads to arrhythmias and heart failure, yet mechano-chemo-transduction (MCT) mechanisms are poorly understood at the single cell level during h
Autor:
Leighton T. Izu, Marius P. Sumandea, Byron Norton, Jeffery R. Erickson, Ye Chen-Izu, Donald M. Bers, Julie Bossuyt, David Yu
Publikováno v:
Biophysical Journal. 100(3)
CaMKII is important in cardiac function and disease, and the two main cardiac isoforms (δC and δB) are targeted to cytosol and nucleus respectively. They regulate many ion channels and Ca2+ handling molecules in excitation-contraction coupling and
Ca(2+) sparks arise from the stochastic opening of spatially discrete clusters of ryanodine receptors called a Ca(2+) release unit (CRU). If the RyR clusters were not spatially separated, then Ca(2+) released from one RyR would immediately diffuse to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29164105590e029a8bfc25c6ca0bce3d
https://europepmc.org/articles/PMC2072070/
https://europepmc.org/articles/PMC2072070/
The availability of high-speed, two-dimensional (2-D) confocal microscopes and the expanding armamentarium of fluorescent probes presents unprecedented opportunities and new challenges for studying the spatial and temporal dynamics of cellular proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be4fb7d3b7a20e001556d1b24fe945a
https://europepmc.org/articles/PMC1877760/
https://europepmc.org/articles/PMC1877760/
Autor:
Ye Chen-Izu, Leighton T. Izu
Publikováno v:
Biophysical Journal. 99:3861-3862