Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stary ‐ Weinzinger, A"'
Publikováno v:
Journal of General Physiology. 151:1231-1246
Inwardly rectifying potassium (Kir) channels play a key role in controlling membrane potentials in excitable and unexcitable cells, thereby regulating a plethora of physiological processes. G-protein–gated Kir channels control heart rate and neuron
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0217377 (2019)
PLoS ONE, Vol 14, Iss 6, p e0217377 (2019)
The human serotonin transporter hSERT facilitates the reuptake of its endogenous substrate serotonin from the synaptic cleft into presynaptic neurons after signaling. Reuptake regulates the availability of this neurotransmitter and therefore hSERT pl
Autor:
Thierry Langer, Marcel A.G. van der Heyden, Arthur Garon, Marcus Wieder, Anna Stary-Weinzinger, Eva-Maria Zangerl-Plessl, Xingyu Chen, Marien J C Houtman
Publikováno v:
Frontiers in Pharmacology, 10. Frontiers Media S. A.
Frontiers in Pharmacology
Frontiers in Pharmacology
KATP channels consist of four Kir6.x pore–forming subunits and four regulatory sulfonylurea receptor (SUR) subunits. These channels couple the metabolic state of the cell to membrane excitability and play a key role in physiological processes such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d480e2dd3003b7475cd505cb3dd9d7a9
https://dspace.library.uu.nl/handle/1874/383430
https://dspace.library.uu.nl/handle/1874/383430
Autor:
Feifei Ren, Colin G. Nichols, Grigory Maksaev, Peng Yuan, Anna Stary-Weinzinger, Eva-Maria Zangerl-Plessl, Sun-Joo Lee, Harald Bernsteiner
Publikováno v:
The Journal of General Physiology
This paper presents the crystal structure of a forced open inward rectifier Kir2.2 channel. Molecular dynamics reveals the details of ion permeation through the open channel.
Potassium ion conduction through open potassium channels is essential
Potassium ion conduction through open potassium channels is essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00994dbf7b4288f390123b4b7439f90
Autor:
Adriaan P. IJzerman, M. Houtman, M A Vos, Anna Stary-Weinzinger, H D M Beekman, Rosanne Varkevisser, Tobias Linder, M. A. G. van der Heyden, K. C. G. de Git, Richard R. Tidwell
Publikováno v:
British Journal of Pharmacology
Background and Purpose Drug interference with normal hERG protein trafficking substantially reduces the channel density in the plasma membrane and thereby poses an arrhythmic threat. The chemical substructures important for hERG trafficking inhibitio
Autor:
Steffen Hering, Eugen Timin, Anna Stary-Weinzinger, Katrin Depil, Annette Hohaus, Stanislav Beyl
Publikováno v:
The Journal of Biological Chemistry
The Timothy syndrome mutations G402S and G406R abolish inactivation of Ca(V)1.2 and cause multiorgan dysfunction and lethal arrhythmias. To gain insights into the consequences of the G402S mutation on structure and function of the channel, we systema
Autor:
Stanislav Beyl, Anna Stary-Weinzinger, Michaela Kudrnac, Steffen Hering, Annette Hohaus, Waheed Shabbir, Eugen Timin, Katrin Depil
Publikováno v:
Pflugers Archiv
Single point mutations in pore-forming S6 segments of calcium channels may transform a high-voltage-activated into a low-voltage-activated channel, and resulting disturbances in calcium entry may cause channelopathies (Hemara-Wahanui et al., Proc Nat
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 9, Iss 5, p e1003058 (2013)
PLoS Computational Biology, Vol 9, Iss 5, p e1003058 (2013)
The bacterial potassium channel KcsA, which has been crystallized in several conformations, offers an ideal model to investigate activation gating of ion channels. In this study, essential dynamics simulations are applied to obtain insights into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3898fb489ece43d44738fed4fbb943
https://doi.org/10.1371/journal.pcbi.1003058
https://doi.org/10.1371/journal.pcbi.1003058
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 12, p e28778 (2011)
PLoS ONE, Vol 6, Iss 12, p e28778 (2011)
Pharmacological inhibition of cardiac hERG K(+) channels is associated with increased risk of lethal arrhythmias. Many drugs reduce hERG current by directly binding to the channel, thereby blocking ion conduction. Mutation of two aromatic residues (F
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 10, Iss 7, p e1003746 (2014)
PLoS Computational Biology, Vol 10, Iss 7, p e1003746 (2014)
Rapid and selective ion transport is essential for the generation and regulation of electrical signaling pathways in living organisms. Here, we use molecular dynamics (MD) simulations with an applied membrane potential to investigate the ion flux of